Antiviral activity of DG-35-VIII, a potent inhibitor of the protease of human immunodeficiency virus

Antiviral Chemistry and Chemotherapy

Volumn 8, Issue 2, 1997, Pages 99-106

  Grobelny, D ^a   Chen, Q ^a   Tyssen, D ^b   Tachedjian, G ^b   Sebire, K ^b,c   Buchanan, L ^b,c   Birch, C ^b,c  

^a LA TROBE UNIVERSITY   (Australia)

^b Macfarlane Burnet Centre for Medical Research   (Australia)

^c FAIRFIELD HOSPITAL   (Australia)

Author keywords

HIV; hydrazide; in vitro activity; protease inhibitor

Indexed keywords

ANTIVIRUS AGENT; DG 35 VIII; HYDRAZIDE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN PROCESSING; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE;

EID: 0031044259     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029700800203     Document Type: Article

References (18)

1. Dutta AS & Morley JS (1975) Polypeptides. Part XIII. Preparation of a-aza-amino-acid (carbazic acid) derivatives and intermediates for the preparation of a-aza-peptides. Journal of the Chemical Society, Perkin Transactions 1, 1712-1720.
2. Friend SCE, Birch CJ, Lording PM, Marshall JA & Studdert MA (1990) Feline immunodeficiency virus: prevalence, disease associations and isolation. Australian Veterinary Journal 67: 237-243.
3. Grobelny D, Wondrak EM, Galardy RE & Oroszlan S (1990) Selective phosphinate transition state analogue inhibitors of protease of human immunodeficiency virus. Biochemical and Biophysical Research Communications 169: 1111-1116.
4. Huff JR (1991) HIV Protease: a novel chemotherapeutic target for AIDS. Journal of Medicinal Chemistry 34:2305-2314.
5. Hunter E (1994) Macromolecular interactions in the assembly of HIV and other retroviruses. Seminars in Virology 5: 7183.
6. 2 symmetric inhibitors of HIV protease. Journal of Medicinal Chemistry 33:2687-2689.
7. Kramer RA, Schaber MD, Sklaka AM, Ganguly K, Wang-Staal F & Reddy EP (1986) HTLV-III gag protein is processed in yeast cells by the virus pol-protease. Science 231:1580-1584.
8. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
9. Luly JR, Dellaria JF, Plattner JJ, Soderquist JL & Yi N (1987) A synthesis of protected aminoalkyl epoxides from a-amino acids. Journal of Organic Chemistry 52:1487-1492.
10. Neate EV, Pringle RC, Jowett JBM, Healey DS & Gust ID (1987) Isolation of HIV from Australian patients with AIDS, AIDS related conditions and healthy antibody positive individuals. Australian and New Zealand Journal of Medicine 17: 461-466.
11. Rich DH, Green J, Toth MV, Marshall GR & Kent SBH (1990) Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease. Journal of Medicinal Chemistry 33:1285-1288.
12. Roberts NA, Martin JA, Kinchington D, Broadhurst AV, Craig JC, Duncan IB, Galpin SA, Handa BK, Kay J, Krohn A, Lambert RW Merrett JH, Mills JS, Parkes KEB, Redshaw S, Ritchie AJ, Taylor DL, Thomas GJ &. Machin PJ (1990) Rational design of peptide based HIV proteinase inhibitors. Science 248:358-361.
13. Smyth NR, McCracken C, Gaskell RM, Cameron JM, Coates JAV, Gaskell CJ, Hart CA & Bennett M (1994) Susceptibility in cell culture of feline immunodeficiency virus to eighteen antiviral agents. Antimicrobial Agents and Chemotherapy 34: 589-594.
14. Tachedjian G, Tyssen D, Locarnini S, Gust I & Birch C (1990) Investigation of topoisomerase inhibitors for activity against human immunodeficiency virus: inhibition by coumermycin A1. Antiviral Chemistry and Chemotherapy 1: 131-138.
15. Talbott RL, Sparger EE, Lovelace KM, Fitch WM, Pedersen NC, Luciw PA & Elder JH (1989) Nucleotide sequence and genomic organization of feline immunodeficiency virus. Proceedings of the National Academy of Sciences, USA 86: 5743-5747.
16. Tomasselli AG, Howe WJ, Sawyer TK, Wlodawer A & Heinrikso RL (1991) The complexities of AIDS: an assessment of the HIV protease as a therapeutic target. Chimica Oggi 9: 6-27.
17. Tomasselli AG, Thaisrivonga S & Heinrikson RL (1996) Discovery and design of HIV protease inhibitors as drugs for the treatment of AIDS. Advances in Antiviral Drug Research 2: 173-228.
18. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BA, Saag MS & Shaw GM (1995) Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373: 117-122.