Ascorbic acid inhibits spinal meningeal catechol-o-methyl transferase in vitro, markedly increasing epinephrine bioavailability

Anesthesiology

Volumn 86, Issue 2, 1997, Pages 405-409

  Kern, C ^a   Bernards, C M ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Ascorbic acid; Epinephrine, diffusion; Metabolism, metanephrine; Spinal meninges, monkey

Indexed keywords

ADRENALIN; ANTIOXIDANT; ASCORBIC ACID; CATECHOL METHYLTRANSFERASE; DRUG METABOLITE; METADRENALIN; NORMETADRENALIN; SODIUM METABISULFITE;

ANIMAL TISSUE; ARTICLE; DRUG BIOAVAILABILITY; DRUG METABOLISM; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID SCINTILLATION COUNTING; MENINX; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; SPINAL CORD;

ANIMALS; ASCORBIC ACID; BIOLOGICAL AVAILABILITY; CATECHOL O-METHYLTRANSFERASE; ENZYME INHIBITORS; FEMALE; MACACA NEMESTRINA; MALE; MENINGES; NOREPINEPHRINE; PERMEABILITY; SPINAL CORD; SULFITES;

EID: 0031044032     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199702000-00015     Document Type: Article

References (19)

1. Bromage PR, Burfoot MF, Crowell DF, Pettigrew RT: Quality of epidural blockade: I. Influence of physical factors. Br J Anaesth 1964; 36:342-52
2. Covino BG, Vassallo HG: Local Anesthetics: Mechanisms of Action and Clinical Use. Edited by Covino BG. Philadelphia, Grune & Statton, 1976, pp 82-4
3. Grice SC, Eisenach JC, Dewan DM: Labor analgesia with epidural bupivacaine plus fentanyl: Enhancement with epinephrine and inhibition with 2-chloroprocaine. ANESTHESIOLOGY 1990; 72:623-8
4. Bromage PR, Camporesi BM, Durant PA, Nielsen CH: Influence of epinephrine as an adjuvant to epidural morphine. ANESTHESIOLOGY 1983; 58:257-62
5. Semple AJ, Macrae DJ, Munishankarappa S, Burrow LM, Milne MK, Grant IS: Effect of the addition of adrenaline to extradural diamorphine analgesia after cesarcan section. Br J Anaesth 1988; 60:632-8
6. Dougherty TB, Baysinger CL, Henenberger JC, Gooding DJ: Epidural hydromorphone with and without epinephrine for postoperative analgesia after cesarean deliver. Anesth Analg 1989; 68:318-22
7. Huang KS, Tseng CH, Cheung KS, Hui YL, Tan PCC: Influence of epinephrine as an adjuvant to epidural morphine for postoperative analgesia. Acta Anaesthesiol Sinica 1993; 31:245-8
8. Kern C, Mautz DS, Bernards CM: Epinephrine is metabolized by the spinal meninges of monkeys and pigs. ANESTHESIOLOGY 1995; 83:1078-81
9. Bernards CM, Hill H: The spinal nerve root sleeve is not a preferred route for redistribution of drugs from epidural space to the spinal cord. ANESTHESIOLOGY 1991; 80:872-8
10. Bernards CM, Hill H: Morphine and alfentanil permeability through the spinal dura, arachnoid and pia mater of dogs and monkeys. ANESTHESIOLOGY 1990; 73:1214-19
11. Bernards CM: Effect of (hydroxypropyl)-β-cyclodextrin on the flux of morphine, fentanyl, sufentanil, and alfentanil through the spinal meninges of the monkey. J Pharmaceut Sci 1994; 83:620-2
12. Blaksche E, Hertting G: Enzymatic methylation of L-ascorbic acid by catechol O-methyltransferase. Biochem Pharmacol 1971; 20:1363-70
13. Bernards CM, Hill H: Physical and chemical properties of drug molecules governing their diffusion through the spinal meninges. ANESTHESIOLOGY 1992; 77:750-6
14. Hugh D, Grennan A, Abugila MA, Weinkove C: Ascorbic acid as an antioxidant in measurements of catecholamines in plasma. Clin Chem 1987; 33:569-71
15. Jouve J, Mariotte N, Sureau C, Muth JP: High performance liquid chromatography and electrochemical detection for the simultaneous detection of the methoxylated amines, normetanephrine, metanephrinc and 3-methoxytyramine, in urine. J Chromatogr 1983; 274:53-62
16. Gulberg HC, Marsden CA: Catechol-O-methyl transferase: Pharmacological aspects and physiological role. Pharmacol Rev 1975; 27:135-206
17. Carpenter RL, Smith HS, Bridenbaugh LD: Epinephrine increases the effectiveness of spinal anesthesia, ANESTHESIOLOGY 1989; 71:33-6
18. Racle J, Benkhadra A, Poy J, Gleizal B: Effect of increasing amounts of epinephrine during isobaric bupivacaine spinal anesthesia in elderly patients. Anesth Analg 1987; 66:882-6
19. Reddy SV, Maderdrut JL, Yaksh TL: Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J Pharmacol Exp Ther 1980; 213:525-33