Regulation of proopiomelanocortin gene expression by endogenous ligands of the GABA(A) receptor complex as evaluated by in situ hybridization in the rat pars intermedia

Brain Research

Volumn 750, Issue 1-2, 1997, Pages 277-284

  Garcia De Yebenes, Esther ^a   Li, Songyun ^a   Pelletier, Georges ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

diazepam binding inhibitor; GABA(A) receptor; octadecaneuropeptide; pars intermedia; pregnenolonesulfate; proopiomelanocortin; trilostane

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; FINASTERIDE; MESSENGER RNA; OCTADECANEUROPEPTIDE; PICROTOXIN; PROOPIOMELANOCORTIN; STEROID 5ALPHA REDUCTASE; TRILOSTANE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPOPHYSIS INTERMEDIATE LOBE; IN SITU HYBRIDIZATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ADRENALECTOMY; ANIMALS; CARRIER PROTEINS; CEREBRAL VENTRICLES; DIAZEPAM BINDING INHIBITOR; DIHYDROTESTOSTERONE; ENZYME INHIBITORS; FINASTERIDE; GABA AGONISTS; IN SITU HYBRIDIZATION; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; MALE; NEURONS; NEUROPEPTIDES; ORCHIECTOMY; PEPTIDE FRAGMENTS; PITUITARY GLAND; PREGNENOLONE; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0031043853     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01367-4     Document Type: Article

References (44)

1. Anderson, R.A. and Mitchell, R., Analysis of benodiazepine binding sites in rat pituitary gland, Brain Res., 323 (1984) 369-373.
2. Baulieu, E.E., Robel, P., Vatier, O., Haug, M., Gascogne, C.I. and Bouneau, E., Neurosteroids: pregnenolone and dehydroepiandrosterone in the brain. In K. Fuxe and L.F. Agnati (Eds.), Receptor Interaction, a New Intra Membrane Integrative Mechanism, MacMillan, Basingstoke, 1987, pp. 89-104.
3. Bender, A.S. and Hertz, L., Octadecaneuropeptide (ODN; "anxiety peptide") displaces diazepam more potently from astrocytic than from neuronal binding sites, Eur. J. Pharmacol., 132 (1986) 335-336.
4. Bender, A.S. and Hertz, L., Pharmacological evidence that the non-neuronal diazepam binding site in primary cultures of glial cells is associated with a calcium channel, Eur. J. Pharmacol., 110 (1985) 287-288.
5. A receptors in the rat pituitary, J. Neurochem., 63 (1994) 10-22.
6. Björklund, A., Moore, R.Y., Nobin, A. and Stenevi, U., The organization of tubero-hypophyseal and reticulo-infundibular catecholamine neuron systems in the rat brain, Brain Res., 51 (1973) 171-179.
7. Blasquez, C., Jégou, S., Bunel, D.T., Delbende, C., Braquet, P. and Vaudry, H., Central-type benzodiazepines inhibit release of α-melanocyte-stimulating hormone from the rat hypothalamus, Neuroscience, 42 (1991) 509-516.
8. Blasquez, C., Jégou, S., Feuilloley, M., Rosier, A., Vandesande, F. and Vaudry, H., Visualization of γaminobutyric acid A receptors on proopiomelanocortin-producing neurons in the rat hypothalami, Endocrinology, 135 (1994) 2759-2764.
9. Cottrell, G.A., Lambert, J.J. and Peters, J.A., Modulation of GABAA receptor activity by alphaxalone, Br. J. Pharmacol., 90 (1987) 491-500.
10. Ferrero, P., Santi, M.R., Conti-Tronconi, B., Costa, E. and Guidotti, A., Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain, Proc. Natl. Acad. Sci. USA, 83 (1986) 827-831.
11. Garcia de Yebenes, E. and Pelletier, G., Control of propiomelanocortin (POMC) mRNA levels in the rat arcuate nucleus by the potential endogenous benzodiazepine (BZD) receptor ligand octadecaneuropeptide (ODN), Proc. Annu. Meet. Soc. Neurosci. Abstr., 21 (1995) 1348.
12. A receptor activation in the rat arcuate nucleus, Peptides, 15 (1994) 615-618.
13. Guidotti, A., Role of DBI in brain and its posttranslational processing products in normal and abnormal behavior, Neuropharmacology, 30 (1991) 1425-1433.
14. Harrison, N.L. and Simmonds, M.A., Modulation of the GABA receptor complex by a steroid anesthetic, Brain Res., 323 (1984) 287-292.
15. Hertz, L. and Bender, A.S., Astrocytic benzodiazepine receptors: their possible role in the regulation of brain excitability. In H.K. Kimelberg (Eds.), Glial Cell Receptors, Raven Press, New York, 1988, pp. 159-181.
16. Jégou, S., Blasquez, C., Delbende, C., Tranchand Bunel, D. and Vaudry, H., Regulation of α-melanocyte-stimulating hormone release from hypothalamic neurons. In H. Vaudry and A.N. Eberle (Eds.), The Melanotropic Peptides, Ann. NY Acad. Sci., New York, 1993, pp. 260-278.
17. A-benzodiazepine receptor complex inhibits proopiomelanocortin gene expression in the rat arcuate nucleus, Mol. Cell. Neurosci., 2 (1991) 440-445.
18. Kramer, C.Y., Extension of multiple range tests to group means with unique numbers of replications, Biometrics, 12 (1956) 307-310.
19. Lamacz, M., Tonon, M.C., Smih-Rouet, F., Patte, C., Gasque, P., Fontaine, M. and Vaudry, H., The endogenous benzodiazepine receptor ligand ODN increases cytosolic calcium in cultured rat astrocytes, Mol. Brain Res., 37 (1996) 290-296.
20. A receptor function, Trends Pharmacol. Sci., 16 (1995) 295-303.
21. A receptor, Trends Pharmacol. Sci., 8 (1987) 224-227.
22. Li, S. and Pelletier, G., Inhibitory effect of the endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), on gonadotropin-releasing hormone gene expression in the male rat brain, NeuroReport, 6 (1995) 1354-1356.
23. Li, S. and Pelletier, G., Role of dopamine in the regulation of gonadotropin-releasing hormone in the male rat brain as studied by in situ hybridization, Endocrinology, 131 (1992) 395-399.
24. Loeffler, J.P., Demeneix, B.A., Pittius, C.W., Kley, N. and Haegele, K.D., GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary, Peptides, 7 (1986) 253-258.
25. A receptor chloride channels in cultured pituitary melanotrophs, Mol. Brain Res., 12 (1992) 1-6.
26. Majewska, M.D., Hamkun, N.L., Schwartz, R.D., Baker, J.L. and Paul, S.M., Steroid hormone metabolites and barbiturate-like modulation of the GABA receptor, Science, 222 (1986) 1004-1007.
27. Majewska, M.D. and Schwartz, R.D., Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutiric acid receptor complex in brain? Brain Res., 404 (1987) 355-360.
28. Malagon, M., Vaudry, H., Stuen, F.V., Pelletier, G., Navarro, F.G. and Tonon, M.C., Ontogeny of diazepam-binding inhibitor related peptides (endozepines) in the rat brain, Neuroscience, 57 (1993) 777-786.
29. McCauley, L.D., Lan, N.C., Tonich, J.M., Shively, J.E. and Gee, K.W., Peripheral type benzodiazepine receptors and the regulation of steroidogenesis in the rat brain mitochondria. In G. Bioggio, A. Comus and S. Costa (Eds.), GABAergic Synaptic Transmission, Raven Press, New York, 1992, pp. 143-147.
30. Melcangi, R.C., Celotti, F., Castano, P. and Martini, L., Intracellular signalling systems controlling the 5α-reductase in glial cell cultures, Brain Res., 585 (1992) 411-415.
31. Morrow, A.L., Pace, J.R., Purdy, R.H. and Paul, S.M., Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites, Mol. Pharmacol., 37 (1990) 263-270.
32. Papadopoulos, V., Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function, Endocr. Rev., 14 (1993) 222-240.
33. Patte, C., Vaudry, H., Desrues, L., Gandolfo, P., Strijdveen, I., Lamacz, M. and Tonon, M.C., The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes, FEBS Lett., 362 (1995) 106-110.
34. Pelletier, G. and Leclerc, R., Immunohistochemical localization of adrenocorticotropin in the rat brain, Endocrinology, 104 (1979) 1426-1433.
35. Pelletier, G., Luu-The, V. and Labrie, F., Immunocytochemical localization of 5α-reductase in rat brain, Mol. Cell. Neurosci., 5 (1994) 394-399.
36. Potts, G.O., Creange, J.E. and Harding, H.R., Trilostane, an orally active inhibitor of steroid biosynthesis, Steroids, 32 (1978) 257-267.
37. A receptors: ligand-gated CL: ion channels modulated by multiple drug-binding sites, Trends Pharmacol. Sci., 13 (1992) 446-450.
38. Tong, Y., Tonon, M.C., Désy, L., Nicolas, P., Vaudry, H. and Pelletier, G., Localization of the endogenous benzodiazepine recep-tor ligand octadecaneuropeptide and peripheral type benzodiazepine receptors in the rat pituitary., J. Neuroendocrinol., 2 (1990) 189-192.
39. Tonon, M.C., Adjeroud, S., Lamazc, M., Louiset, E., Danger, J.M., Desrues, L., P., Nicolas and Vaudry, H., Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of α-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro, Neuroscience, 31 (1989) 485-493.
40. Tonon, M.C., Désy, L., Nicolas, P., Vaudry, H. and Pelletier, G., Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain, Neuropeptides, 15 (1990) 17-24.
41. Vincens, M., Li, S.Y. and Pelletier, G., Inhibitory effect of 5β-pregnan-3α-ol-20-one on gonadotropin-releasing hormone gene expression in the male rat, Eur. J. Pharmacol., 260 (1994) 157-162.
42. Vincent, S.R., Hokfelt, T. and Wu, J.Y., GABA neuron systems in hypothalamus and pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase, Neuroendocrinology, 34 (1982) 117-125.
43. Vuillez, P., Perez, S.C. and Stoeckel, M.E., Co-localization of GABA and tyroxine hydroxylase immunoreactivities in the axons innervating the neurointermediate lobe of the rat pituitary: an ultrastructural immunogold study, Brain Res., 79 (1987) 53-58.
44. Young, J., Corpéchot, C., Perché, F., Haug, M., Baulieu, E.E. and Robel, P., Neurosteroids: pharmacological effect of a 3β-hydroxysteroid dehydrogenase inhibitor, Endocrine, 2 (1994) 505-509.