Resistance exercise overtraining and overreaching: Neuroendocrine responses

Sports Medicine

Volumn 23, Issue 2, 1997, Pages 106-129

  Fry, Andrew C ^a   Kraemer, William J ^b  

^a UNIVERSITY OF MEMPHIS   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMMONIA; CORTICOTROPIN; CREATINE KINASE; GROWTH HORMONE; HYDROCORTISONE; LACTIC ACID; LUTEINIZING HORMONE; NORADRENALIN; PEPTIDE F; STEROID HORMONE; TESTOSTERONE;

ADAPTATION; CIRCADIAN RHYTHM; EXERCISE; HUMAN; NEUROENDOCRINE SYSTEM; OVEREXERTION; PERFORMANCE; REVIEW; STIMULUS; SYMPATHETIC TONE; TRAINING;

EID: 0031043740     PISSN: 01121642     EISSN: None     Source Type: Journal    
DOI: 10.2165/00007256-199723020-00004     Document Type: Review

References (183)

1. Fry AC, Kraemer WJ, van Borselen F, et al. Performance decrements with high-intensity resistance exercise overtraining. Med Sci Sports Exerc 1994; 26 (9): 1165-73
2. O'Connor PJ, Morgan WP, Raglin JS, et al. Selected psychoendocrine responses to overtraining [abstract]. Med Sci Sports Exerc 1989; 21 Suppl. 2: S50
3. Bourguignon J-P, Hoyoux C, Reuter A, et al. Urinary excretion of immunoreactive luteinizing hormone-releasing hormone-like material and gonadotropins at different stages of life. J Clin Endocrinol Metab 1979; 48: 78-84
4. Fellman N, Bedu M, Boudet G, et al. Inter-relationships between pituitary-adrenal hormones and catecholamines during a 6-day Nordic ski race. Eur J Appl Physiol 1992; 64: 258-65
5. Lehmann M, Gastmann U, Petersen KG, et al. Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle-and long-distance runners. Br J Sports Med 1992; 26: 233-42
6. Stone MH, Keith RE, Kearney JT, et al. Overtraining: a review of the signs, symptoms and possible causes. J Appl Sports Sci Res 1991; 5 (1): 35-50
7. Adlercreutz H, Härkönen M, Kuoppasalmi K, et al. Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. Int J Sports Med 1986; 7 Suppl.: 27-8
8. Budgett R. Overtraining syndrome. Br J Sports Med 1990; 24 (4): 231-6
9. Lehmann M, Dickhuth H, Gendrisch G, et al. Training-overtraining. A prospective, experimental study with experienced middle- and long-distance runners. Int J Sports Med 1991; 12 (5): 444-52
10. Hooper SL, MacKinnon LT, Gordon RD, et al. Hormonal responses of elite swimmers to overtraining. Med Sci Sports Exerc 1993; 25: 741-7
11. Lehmann M, Foster C, Keul J. Overtraining in endurance athletes: a brief review. Med Sci Sports Exerc 1993; 25: 854-62
12. Kindermann W. Overtraining - Expression of a disturbed autonomic regulation. Dtsch Z Sportmed 1986; 37: 238-45
13. Kirwan JP, Costill DL, Flynn MG, et al. Physiological responses to successive days of intense training in competitive swimmers. Med Sci Sports Exerc 1988; 20 (3): 255-9
14. Stray-Gunderson J, Videman T, Snell PG. Changes in selected objective parameters during overtraining [abstract]. Med Sci Sports Exerc 1986; 18 Suppl. 2: S54-5
15. Urhausen, A, Gabriel H, Kindermann W. Blood hormones as markers of training stress and overtraining. Sports Med 1995; 20 (4): 251-76
16. Kuipers H, Keizer HA. Overtraining in elite athletes, review and directions for the future. Sports Med 1988; 6: 79-92
17. Jeukendrup AE, Hesselink MK. Overtraining - what do lactate curves tell us? Br J Sports Med 1994; 28 (4): 239-40
18. Fry RW, Morton AR, Keast D. Overtraining in athletes, an update. Sports Med 1991; 12 (1): 32-65
19. Vervoorn C. Neuro-endocrine aspects of exercise and training. Utrecht: Elinkwijk B.V., 1992
20. Häkkinen K, Keskinen KL, Alén M, et al. Serum hormone concentrations during prolonged training in elite endurance-trained and strength-trained athletes. Eur J Appl Physiol 1989; 59: 233-8
21. Busso T, Häkkinen K, Pakarinen A, et al. A systems model of training responses and its relationship to hormonal responses in elite weight-lifters. Eur J Appl Physiol 1990; 61: 48-54
22. Fry AC, Kraemer WJ, Stone MH, et al. Endocrine responses to overreaching before and after 1 year of weightlifting. Can J Appl Physiol 1994; 19 (4): 400-10
23. Fry AC, Kraemer WJ, Stone MH, et al. Endocrine and performance responses to high volume training and amino acid supplementation in elite junior weightlifters. Int J Sports Nutr 1993; 3: 306-22
24. Fry AC, Kraemer WJ, Stone MH, et al. Endocrine and performance responses during one month of periodized weightlifting with amino acid supplementation [abstract]. J Appl Sport Sci Res 1992; 6 (3): 183
25. Fry AC, Kraemer WJ, Lynch JM, et al. Does short-term near-maximal intensity machine resistance exercise induce overtraining? J Str Cond Res 1994; 8 (3): 188-91
26. Häkkinen K, Pakarinen A, Alén M, et al. Relationships between training volume, physical performance capacity, and serum hormone concentrations during prolonged training in elite weight lifters. Int J Sports Med 1987; Suppl. 8: 61-5
27. Häkkinen K, Pakarinen A, Alén M, et al. Daily hormonal and neuromuscular responses to intensive strength training in 1 week. Int J Sports Med 1988; 9 (6): 422-8
28. Brown RL, Frederick EC, Falsetti HL, et al. Overtraining of athletes - a round table. Phys Sports Med 1983; 11 (6): 93-110
29. Callister R, Callister RJ, Fleck SJ, et al. Physiological and performance responses to overtraining in elite judo athletes. Med Sci Sports Exerc 1990; 22 (6): 816-24
30. Morgan WP, Brown DR, Raglin JS, et al. Psychological monitoring of overtraining and staleness. Br J Sports Med 1987; 21 (3): 107-14
31. Newsholme EA, Blomstrand E, McAndrew N, et al. Biochemical causes of fatigue and overtraining. In: Shepherd RJ, Åstrand P-O, editors. Endurance in Sports. London: Blackwell Scientific Publications, 1992: 351-64
32. Selye H. The Stress of Life. New York: McGraw-Hill, 1956
33. van Borselen F, Vos NH, Fry AC, et al. The role of anaerobic exercise in overtraining. Natl Str Cond Assoc J 1992; 14 (3): 74-9
34. Parry-Billings M, Blomstrand F, McAndrew N, et al. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med 1990; 11 Suppl. 2: S122-8
35. Hagerman FC. Failing to adapt to training. FISA Coach 1992; 3 (1): 1-4
36. Israel S. The problems of overtraining with reference to performance physiology and internal medicine [in German]. Med Sport 1976; 16 (1): 1-12
37. Costill DL, Thomas R, Robergs RA, et al. Adaptations to swimming training: influence of training volume. Med Sci Sports Exerc 1991; 23 (3): 371-7
38. Dressendorfer RH, Wade CE, Scaff JH. Increased morning heart rate in runners: a valid sign of overtraining? Phys Sportsmed 1985; 13 (8): 77-86
39. Flynn MG, Pizza FX, Andres FF, et al. Indices of training stress during competitive running and swimming seasons. Int J Sports Med 1994; 15: 21-6
40. Griffith RO, Dressendorfer RH. Effects of overwork on testosterone, sperm count, and libido [abstract]. Med Sci Sports Exerc 1988; 20 (2): S39
41. Grumbach MM, Roth JC, Kaplan SL. Hypothalamic-pituitary regulation of puberty in man: evidence and concepts derived from clinical research. In: Grumbach MM, Grave GD, Mayer FE, editors. Control of the onset of puberty. New York: John Wiley and Sons, 1974: 115-66
42. Lehmann M, Dickhuth H, Lazar W, et al. Four weeks overtraining study in long-distance runners [abstract]. FIMS World Congress of Sports Medicine: 1990; Amsterdam
43. Lehmann M, Jakob E, Dickhuth H-H, et al. Sympathetic activity in relation to performance diagnostics, training and overtraining [abstract]. Int J Sports Med 1988; 9: 390-1
44. Sutton JR, Farrell PA, Harber VJ. Hormonal adaptation to physical activity. In: Bouchard C, Shephard RJ, Stephens T, et al., editors. Exercise, fitness and health. Champaign (IL): Human Kinetics Publishers, 1990: 217-63
45. Kame VD, Pendergast DR, Termin, B. Physiologic responses to high intensity training in competitive university swimmers. J Swimming Res 1990; 6 (4): 5-8
46. Fry AC, Kraemer WJ, van Borselen F, et al. Catecholamine responses to short-term high-intensity resistance exercise overtraining. J Appl Physiol 1994; 77 (2): 941-6
47. Fry AC, Kraemer WJ, van Borselen F, et al. Endocrine responses to short-term intensity-specific resistance exercise overtraining [abstract]. J Str Cond Res 1993; 7 (3): 179
48. Fry AC, Ramsey LT, Kraemer WJ, et al. Plasma proenkephalin peptide F responses to short-term high-intensity resistance exercise overtraining. Eur J Appl Physiol. In press
49. Costill DL, Flynn MG, Kirwan JP, et al. Effects of repeated days of intensified training on muscle glycogen and swimming performance. Med Sci Sports Exerc 1988; 20 (3): 249-54
50. Fleck SJ, Kraemer WJ. Designing resistance exercise programmes. Champaign (IL): Human Kinetics Publishers, 1987
51. Galbo H. Hormonal and metabolic adaptation to exercise. Stuttgart: Georg Thieme Verlag, 1983
52. Galbo H. Endocrine factors in endurance. In: Shepherd RJ, Åstrand P-O, editors. Endurance in sports. London: Blackwell Scientific Publications, 1992: 116-26
53. Kraemer WJ. Endocrine responses to resistance exercise. Med Sci Sports Exerc 1988: 20 Suppl. 5: S152-7
54. Kraemer WJ. Endocrine responses and adaptations to strength training. In: Komi PV, editor. Strength and power in sport. London: Blackwell Scientific Publications, 1992: 291-304
55. Kraemer WJ, Patton JF, Gordon SE, et al. Compatibility of high-intensity strength and endurance training on hormonal and skeletal muscle adaptations. J Appl Physiol 1995; 78 (3): 976-89
56. Kraemer WJ, Patton JF, Knuttgen HG, et al. Effects of high-intensity cycle exercise on sympathoadrenal-medullary response patterns. J Appl Physiol 1991; 70 (1): 8-14
57. Wheeler GD, Wall SR, Belcastro AN, et al. Reduced serum testosterone and prolactin levels in male distance runners. J Am Med Assoc 1984; 252: 514-6
58. Kraemer WJ, Gordon SE, Fleck SJ, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med 1991; 12 (2): 228-35
59. Kraemer WJ, Marchitelli L, Gordon SE, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 1990; 69 (4): 1442-50
60. Kraemer WJ, Fry AC, Warren BJ, et al. Acute hormorral responses in elite junior weightlifters. Int J Sports Med 1992; 13 (20): 103-9
61. McMillan JL, Stone MH, Sartin J, et al. 20-hour physiological responses to a single weight-training session. J Str Cond Res 1993; 7 (1): 9-21
62. Alén M, Pakarinen A, Häkkinen K, et al. Responses of serum androgenic-anabolic and catabolic hormones to prolonged strength training. Int J Sports Med 1988; 9 (3): 229-33
63. Häkkinen K, Pakarinen A, Alén M, et al. Neuromuscular and hormonal adaptations in athletes to strength training in two years. J Appl Physiol 1988; 65 (6): 2406-12
64. Martini L, Celotti F, Lechuga MJ, et al. Androgen metabolism in different target tissues. Ann NY Acad Sci 1990; 595: 184-98
65. Silva NL, Boulant JA. Effects of testosterone, estradiol, and temperature on neurons in preoptic tissue slices. Am J Physiol 1986; 19: R625-32
66. Kjaer M, Farrell PA, Christensen NJ, et al. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol 1986; 61 (5): 1693-1700
67. Péronnet F, Cléroux J, Perrault H, et al. Plasma norepinephrine response to exercise before and after training in humans. J Appl Physiol 1981; 51 (4): 812-5
68. Fry AC, Kraemer WJ, Koziris LP, et al. The effect of chronic training on plasma dopamine concentrations during acute resistance exercise [abstract]. Mid-Atlantic ACSM: 1992; Winchester (MD)
69. Deschenes MR, Kraemer WJ, Maresh CM, et al. Exercise-induced hormonal changes and their effects upon skeletal muscle tissue. Sports Med 1991; 12 (2): 80-93
70. Thuma JR, Gilders R, Verdun M, et al. Circadian rhythm of cortisol confounds cortisol responses to exercise: implications for future research. J Appl Physiol 1995; 78 (5): 1657-64
71. Wilson JD, Griffin JE. The use and misuse of androgens. Metabolism 1980; 29: 1278-95
72. Burgos MH, Vitale-Calpe R, Aoki A. Fine structure of the testis und its functional significance. In: Johnson AD, Gomes WR, Vandemark NL, editors. The testis. New York: Academic Press, 1970: 551-649
73. Lipsett M. Steroid hormones. In: Yen SSC, Jaffe RB, editors. Reproductive endocrinology: physiology, pathophysiology and clinical management. Philadelphia: W.B. Saunders, 1986; 140-153
74. Griffin JE, Wilson JD. Disorder of the testes and the male reproductive tract. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th ed. Philadelphia: W.B. Saunders, 1992: 799-852
75. Florini JR. Hormonal control of muscle cell growth. J Anim Sci 1985; 61: 21-37
76. Silverman AJ, Krey LC, Zimmerman EA. A comparative study of the luteinizing hormone releasing hormone (LHRH) neuronal networks in mammals. Biol Reprod 1979; 20: 98-110
77. Dufau ML, Catt KJ. Gonadotropin receptors and regulation of steroidogenesis in the testis and ovary. Vitam Horm 1978; 36: 461-592
78. Robaire B, Bayly SF. Testicular signaling: Incoming and outgoing messages. Ann NY Acad Sci 1989; 564: 250-60
79. Häkkinen K, Pakarinen A, Alén M, et al. Serum hormones during prolonged training of neuromuscular performance. Eur J Appl Physiol 1985; 53: 287-93
80. Cumming DC, Wheeler GD, McColl EM. The effect of exercise on reproductive function in men. Sports Med 1989; 7: 1-17
81. Häkkinen K, Pakarinen A. Serum hormones in male strength athletes during intensive short-term strength training. Bur J Appl Physiol 1991; 63: 194-9
82. Staron RS, Karapondo DL, Kraemer WJ, et al. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 1994; 76 (3): 1247-55
83. Barron JL, Noakes TD, Levy W, et al. Hypothalamic dysfunction in overtrained athletes. J Clin Endocrinol Metab 1985; 60: 803-6
84. Triplett NT, Kraemer WJ, Fry AC, et al. Hormonal responses to tournament wrestling [abstract]. Med Sci Sports Exerc 1993; 25 (5): S171
85. Fry RW, Morton AR, Garcia-Webb P, et al. Monitoring exercise stress by changes in metabolic and hormonal responses over a 24-h period. Eur J Appl Physiol 1991; 63: 228-34
86. Bleisch WV, Harrelson A. Androgens modulate endplate size and ACh receptor density at synapses in rat levator ani muscle. J Neurobiol 1989; 20 (4): 189-202
87. Sanghera MK, Grady S, Smith W, et al. Incertohypothalamic A13 dopamine neurons: effect of gonadal steroids on tyrosine hydroxylase. Neuroendocrinol 1991; 53: 268-75
88. Deschenes MR, Maresh CM, Covault JM, et al. Endurance and resistance exercise induce muscle fiber type specific responses in androgen binding. J Steroid Biochem Mol Biol 1994; 50 (3-4): 175-9
89. Vaitukaitis JL, Ross GD, Braunstein GD, et al. Gonadotropins and their subunits: basic and clinical studies. Recent Prog Horm Res 1976; 32: 289-331
90. Dufau ML, Veldhuis JD, Fraioli F, et al. Mode of secretion of bioactive luteinizing hormone in man. J Endocrinol Metab 1983; 57: 993-1000
91. Conn PM, Morrell DV, Dufau ML, et al. Gonadotropin releasing hormone action in cultured pituicytes: independence of luteinizing hormone release and adenosine 3′,5′-monophosphate production. Endocrinology 1979; 104: 448-53
92. Lacroix A, McKenna TJ, Rabinowitz D. Sex steroid modulation of gonadotropins in normal men and androgen insensitivity syndrome. J Clin Endocrinol Metab 1979; 48: 235-40
93. Hyatt PJ, Bhatt K, Tait JF. Steroid biosynthesis by zona fasciculata and zona reticularis cells purified from the mammalian adrenal cortex. J Steroid Biochem 1983; 19: 953-9
94. Orth DN, Kovacs WJ, Debold CR. The adrenal cortex. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th Edition. Philadelphia: W.B. Saunders, 1992: 489-619
95. Rousseau GG, Baxter JD, Higgins SJ. Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells. J Mol Biol 1973; 79: 539-54
96. Jones MT, Gillham B. Factors involved in the regulation of adrenocorticotropic hormone/β-lipotropic hormone. Physiol Rev 1988; 68: 743-818
97. Beyer HS, Matta SG, Sharp BM. Regulation of the messenger ribonucleic acid for corticotropin-releasing factor and vasopressin in the paraventricular nucleus and other brain sites of the rat. Endocrinology 1988; 123: 2117-23
98. Lundblad JR, Roberts JL. Regulation of proopiomelanocortin gene expression in pituitary. Endocrin Rev 1988; 9: 135-58
99. Hall PF. Trophic stimulation of steroidogenesis: in search of the elusive trigger. Recent Prog Horm Res 1985; 41: 1-31
100. Holzwarth MA, Cunningham LA, Kleitman N. The role of adrenal nerves in the regulation of adrenocortical function. Ann NY Acad Sci 1987; 512: 449-64
101. Chen YZ, Hua SY, Wang CA, et al. An electrophysiological study on the membrane receptor-mediated action of glucocorticoids in mammalian neurons. Neuroendocrinol 1991; 53 Suppl. 1: 25-30
102. Ciranello RD. Regulation of adrenal catecholamine biosynthetic enzymes: integration of neuronal and hormonal stimuli in response to stress. In: Usdin E, Kvetnansky R, Kopin IJ, editors. Catecholamines and stress: recent advances. New York: Elsevier/North Holland, 1980: 317-27
103. Kalin NH, Dawson GW. Neuroendocrine dysfunction in depression: hypothalamic-anterior pituitary systems. Trends Neurosci 1986; 9: 261-6
104. Eipper BA, Mains RE. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endocr Rev 1980; 1: 1-27
105. Jackson RV, DeCherney GS, DeBold CR, et al. Synthetic ovine corticotropin- releasing hormone: simultaneous release of proopiomelanocortin peptides in man. J Clin Endocrinol Metab 1984; 58: 740-3
106. Catalano RD, Stuve L, Ramachandran J. Characterization of corticotropin receptors in human adrenocortical cells. J Clin Endocrinol Metab 1986; 62: 300-4
107. Gill GN. ACTH regulation of the adrenal cortex. Pharmacol Ther 1976; 2: 313-38
108. Farrell PA. Adrenocorticotropic hormone and exercise. In: Fotherby K, Pal SB, editors. Exercise endocrinology. New York: Walter de Gruyter, 1985: 139-56
109. Vale W, Speiss J, Rivier C, et al. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981; 213: 1394-7
110. Veldhuis JD, Iranmanesh A, Johnson ML, et al. Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the myctohemeral rhythm of the corticotropic axis in man. J Clin Endocrinol Metab 1990; 71: 452-63
111. Vlahos CJ, Matter WF. Signal transduction in neutrophil activation phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation. FEBS 1992; 309: 242-8
112. Weitzman ED, Fukushima DK, Nogeire C, et al. Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 1971; 33: 14-22
113. Rivier C, Brownstein M, Speiss J, et al. In vivo corticotropin-releasing factor-induced secretion of adrenocorticotropin. β-endorphin and corticosterone. Endocrinology 1982; 110: 272-8
114. Millan MA, Abou-Samra AB, Wynn PC, et al. Receptors and action of corticotropin-releasing hormone in the primate pituitary gland. J Clin Endocrinol Metab 1987; 64: 1036-41
115. Giguere V, Labrie F, Côte J, et al. Stimulation of cyclic AMP accumulation and corticotropin release by ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action. Proc Natl Acad Sci USA 1982; 79: 3466-9
116. Al-Damluji S. Adrenergic mechanisms in the control of corticotropin secretion J Endocrinol 1988; 119: 5-14
117. Kjaer M, Secher NH, Bach FW, et al. Role of motor center activity for hormonal changes and substrate mobilization in humans. Am J Physiol 1987; 253: R687-95
118. Häkkinen K, Pakarinen A. Acute hormonal responses to two different fatiguing heavy-resistance protocols in male athletes. J Appl Physiol 1993; 74 (2): 882-7
119. Koziris LP, Fry AC, Kraemer WJ, et al. Hormonal and competitive performance responses to an overreaching training stimulus in elite junior weightlifters [abstract]. J Appl Sport Sci Res 1992; 6 (3): 186
120. Vervoorn C, Quist AM, Vermulst LJM, et al. The behavior of plasma free testosterone/cortisol ratio during a season of elite rowing training. Int J Sports Med 1991; 12 (3): 257-63
121. Thorner MO, Vance ML, Horvath E, et al. The anterior pituitary. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th Edition. Philadelphia: W.B. Saunders, 1992: 221-310
122. Lewis UL. Growth hormone: what is it and what does it do? TEM 1992; 3 (4): 117-21
123. Luthman M I, Jonsdottir B, Skoog IL, et al. Monoclonal antibodies reveal circulating GH of higher molecular weight not detectable by conventional assays. Acta Endocrinol 1990; 123: 317-25
124. Salmon Jr WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 1957; 49: 825
125. Kostyo JL, Hotchkiss J, Knobil E. Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro. Science 1959; 130: 1653-4
126. Atkison PR, Weidman ER, Baumhick B. Release of somatomedin-like activity by cultured W1-38 human fibroblasts. Endocrinol 1980; 106: 2006-12
127. Van Helder WP, Radomski MW, Goode RC. Growth hormone responses during intermittent weight lifting exercise in men. Eur J Appl Physiol 1984; 53: 31-4
128. Lukaszewska J, Biczowa B, Bobilewicz D, et al. Effect of physical exercise on plasma cortisol and growth hormone levels in young weight lifters. Endokrynol Pol 1976; 27 (2): 149-57
129. Skierska E, Ustupska J, Biczowa B, et al. Effect of physical exercise on plasma cortisol, testosterone and growth hormone levels in weight lifters. Endokrynol Pol 1976; 27 (2): 159-65
130. Landsberg L, Young JB. Catecholamines and the adrenal medulla. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th Ed. Philadelphia: W.B. Saunders, 1992: 621-705
131. Ashkar E, Stevens JJ, Houssay B. Role of the sympathico-adrenal system in the hemodynamic response to exercise in dogs. Am J Physiol 1968; 214: 22-7
132. Ruffolo RR. Spare alpha adrenoceptors in the peripheral circulation: excitation-contraction coupling. Fed Proc 1986; 45: 2341-6
133. Tomita T. Actions of catecholamines on skeletal muscle. In: Greep RO, Astwood EB, editors. Handbook of physiology. Sect. 7: Endocrinology, vol. VI. Washington, DC: American Physiological Society, 1975: 537-52
134. Richter EA, Ruderman NB, Galbo H. Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiol Scand 1982; 116: 215-22
135. Häkkinen K, Pakarinen A, Alén M, et al. Neuromuscular and hormonal responses in elite athletes to two successive strength training sessions in one day. Eur J Appl Physiol 1988; 57: 133-9
136. Richter EA, Ruderman NB, Gavros H, et al. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol 1982; 242 (Endocrinol Metab 5): E25-E32
137. Heinsimer JA, Lefkowitz RJ. Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications. J Lab Clin Med 1982; 100: 641-58
138. Coupland RE. The chromaffin system. In: Blaschko H, Muscholl E, editors. Catecholamines: handbook of experimental pharmacology, Vol. 33. Berlin: Springer-Verlag, 1972; 16-39
139. Perlman RL, Chalfie M. Catecholamine release from the adrenal medulla. Clin Endocrinol Metab 1977; 6: 551-76
140. Perlman RL, Role LW. The coordinate control of catecholamine secretion, synthesis and reuptake in chromaffin cells. In: Ben-Jonathan N, Bahr JM, RI Weiner, editors. Catecholamines as hormone regulators. New York: Raven Press, 1985: 215-21
141. Ciranello RD. Regulation of phenylethanolamine-N-methyltransferase In: Usdin E, Snyder S, editors. Frontiers in catecholamine research. New York: Pergamon, 1973: 101-5
142. Nesher R, Karl IE, Kipnis DM. Epitrochlearis muscle. II. Metabolic effects of contraction and catecholamines. Am J Physiol 1980: 239 (Endocrinol Metah 2): E461-7
143. Holmberg E, Waldeck B. On the possible role of potassium ions in the action of terbutaline on skeletal muscle contractions. Acta Pharmacol et Toxicol 1980; 46: 141-9
144. Fellenius E, Hedberg R, Holmberg E, et al. Functional and metabolic effects of terbutaline and propranolol in fast- and slow-contracting skeletal muscle. Acta Physiol Scand 1980; 109: 89-95
145. Clausen T, Flatman JA. β2-Adrenoceptors mediate the stimulating effect of adrenaline on active electrogenic Na-K-transport in rat soleus muscle. Br J Pharmac 1980; 68: 749-55
146. Carlson E, Fellenius E, Lundborg P, et al. β-Adrenoceptor blockers, plasma- potassium, and exercise. Lancet 1978; II: 424-5
147. Issekutz B. Role of beta-adrenergic receptors in mobilization of energy sources in exercising dogs. J Appl Physiol 1978; 44: 869-76
148. Clar MG, Patten GS. Adrenaline activation of phosphofructokinase in rat heart mediated by alpha-receptor mechanism independent of cyclic AMP. Nature 1981; 292: 461-3
149. Hirano T, Kobayashi S. A functional heterogeneity in chromaffin cells of the mouse adrenal medulla. In: Izumi F, Oka M, Kumakura K, editors. Synthesis, storage and secretion of adrenal catecholamines. Oxford: Pergamon Press, 1982: 127-33
150. Kinderman W, Schnabel A, Schmitt WM, et al. Catecholamines, growth hormone, cortisol, insulin and sex hormones in anaerobic and aerobic exercise. Eur J Appl Physiol 1982; 49: 389-99
151. Jezova D, Vigas M, Tatár P, et al. Plasma testosterone and catecholamine responses to physical exercise of different intensities in men. Eur J Appl Physiol 1985; 54: 62-6
152. Lehmann M, Keul J. Free plasma catecholamines, heart rates, lactate levels, and oxygen uptake in competition weight lifters, cyclists, and untrained control subjects. Int J Sports Med 1986; 7 (1): 18-21
153. Stone MH, Fry AC, Kraemer WJ, et al. Physiological responses to short term overreaching in weightlifting: a report to the U.S. Weightlifting Federation Board of Directors. Colorado Springs: U.S. Weightlifting Federation, 1993
154. Péronnet F, Thibault G, Perrault H, et al. Sympathetic response to maximal bicycle exercise before and after leg strength training. Eur J Appl Physiol 1986; 55: 1-4
155. Jost J, Weiss M, Weicker H. Comparison of sympatho-adrenergic regulation at rest and of the adrenoceptor system in swimmers, long-distance runners, weight lifters, wrestlers, and untrained men. Eur J Appl Physiol 1989; 58: 596-604
156. Eik-nes KB. An effect of isoproterenol on rates of synthesis and secretion of testosterone. Am J Physiol 1969; 217 (6): 1764-70
157. Jezova D, Vigas M. Testosterone response to exercise during blockade and stimulation of adrenergic receptors in man. Hormone Res 1981; 15: 141-7
158. Brown MJ, Jenner DA, Allison DJ, et al. Variations in individual organ release of noradrenaline measured by an improved radioenzymatic technique: limitations of peripheral venous measurements in the assessment of sympathetic nervous activity. Clin Sci 1981; 61: 585-90
159. Kopin IJ. Catecholamine metabolism (and the biochemical assessment of sympathetic activity). Clin Endocrinol Metab 1977; 6: 525-49
160. Tipton KF. Biochemical aspects of monoamine oxidase. Br Med Bull 1973; 29: 116-9
161. Iverson LL. Catecholamine uptake process. Br Med Bull 1973; 29: 130-5
162. Hjemdahl P. Measurements of plasma catecholamines by HPLC and the relation of their concentrations to sympathoadrenal activity. In. Joseph MH, Fillenz M, Macdonald IM, editors. Monitoring neurotransmitter release during behaviour. Chichester: Ellis Horwood, 1986: 17-32
163. Wallin BG, Sundlof G, Eriksson B-M, et al. Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiol Scand 1981; 111: 69-73
164. Smith AD, Winkler H. Fundamental mechanisms in the release of catecholamines. In: Blaschko H, Muscholl E, editors. Catecholamines, Handbook of experimental pharmacology, Vol. 33. Berlin: Springer-Verlag, 1972: 538-617
165. Guezennec Y, Leger L, Lhoste F, et al. Hormone and metabolite response to weight-lifting training sessions. Int J Sports Med 1986; 7: 100-5
166. Kilpatrick DL, Lewis RV, Stein S,et al. Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands. Proc Natl Acad Sci USA 1980; 77: 7473-5
167. Livett AR, Dean DM, Whelan LG, et al. Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells. Nature 1981; 289: 317-9
168. Udenfriend S, Kilpatrick DL. Proenkephalin and the products of its processing: chemistry and biology. In: The peptides, Vol. 6. Orlando (FL): Academic Press, 1984: 25-68
169. Hiddinga HJ, Isaak DD, Lewis RV. Enkephalin-containing peptides processed from the proenkephalin significantly enhances the antibody-forming cell responses to antigens. J Immun 1994; 152: 3748-59
170. Lett E, Gangloff S, Zimmerman M, et al. Immunogenicity of polysaccharides conjugated to peptides containing T- and B-cell epitopes. Infect Immun 1994; 62: 785-92
171. Kraemer WJ, Noble B, Culver B, et al. Changes in plasma proenkephalin peptide F and catecholamine levels during graded exercise in men. Proc Natl Acad Sci USA 1985; 82: 6349-51
172. Katzenstein GE, Lund D, Schultz P, et al. Target tissue distribution of the proenkephalin peptides F, E, and B. Biochem Biophys Res Commun 1987; 146: 184-90
173. Ebbeling CB, Clarkson PM. Exercise-induced muscle damage and adaptation. Sports Med 1989; 7 (4): 207-34
174. Kraemer WJ, Dziados JE, Marchitelli LJ, et al. Effects of different heavy-resistance exercise protocols on plasma β-endorphin concentrations. J Appl Physiol 1993; 74 (1): 450-9
175. Asmussen E, Klausen K, Nielsen LE, et al. Lactate production and anaerobic work capacity after prolonged exercise. Acta Physiol Scand 1966; 50: 731-42
176. Stone ME, Keith RE, Marple D, et al. Heart rate and lactate levels during weight-training exercise in trained and untrained men. Phys Sportsmed 1987; 15: 97-105
177. Tannen RL. Ammonia metabolism. Am J Physiol 1978; 235 (4): F265-77
178. Lowenstein JM. Ammonia production in muscle: the purine nucleotide cycle. Physiol Rev 1972; 52 (2): 382-414
179. Banister EW, Rajendra W, Mulch BJC. Ammonia as an indicator of exercise stress: implications of recent findings to sports medicine. Sports Med 1985; 2 (1): 34-46
180. Stone MH, Keith RE, Marple D, et al. Physiological adaptations during a one-week junior elite weightlifting camp. Conference Abstracts, Southeastern American College of Sports Medicine: 1989
181. Warren BJ, Stone MH, Kearney JT, et al. The effects of short-term overwork on performance measures and blood metabolites in elite junior weightlifters. Int J Sports Med 1992; 13: 372-6
182. Stone MH, O'Bryant H, Garhammer J. A hypothetical model for strength training. J Sports Med Phys Fit 1981; 21: 342-51
183. Fry RW, Morton AR, Keast D. Periodisation and the prevention of overtraining. Can J Sport Sci 1992; 17: 241-8