Small hepatocellular carcinomas in cirrhotic explant livers: Identification by macroscopic examination and lipiodol localization

Hepatology

Volumn 25, Issue 3, 1997, Pages 613-618

  Bhattacharya, Satyajit ^a   Dhillon, Amar Paul ^a   Rees, Julia ^a   Savage, Kay ^a   Saada, Janak ^a   Burroughs, Andrew ^a   Rolles, Keith ^a   Davidson, Brian ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IODINATED POPPYSEED OIL;

ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; EXPLANT; HUMAN; HUMAN TISSUE; INTRAARTERIAL DRUG ADMINISTRATION; LIVER ANGIOGRAPHY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; LIVER TRANSPLANTATION; PRIORITY JOURNAL; SOFT TISSUE RADIOGRAPHY;

CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; HUMANS; IODIZED OIL; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER TRANSPLANTATION;

EID: 0031043706     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510250320     Document Type: Article

References (20)

1. Ferrell L, Wright T, Lake J, Roberts J, Ascher N. Incidence and diagnostic features of macro-regenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers. HEPATOLOGY 1992;16:1372-1381.
2. Theise ND, Schwartz M, Miller C, Thung SN. Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver expiants with cirrhosis. HEPATOLOGY 1992;16:949-955.
3. Nakakuma K, Tashiro S, Uemura K, Hiraoka T, Konno T, Miyauchi Y. Studies on anticancer treatment with an oily anticancer drug injected into the ligated hepatic artery for hepatic cancer. Nichidoku Iho 1979;24:675-682.
4. Demetris AJ, Jaffe R, Starzl TE. A review of adult and pediatric post-transplant liver pathology. Pathol Annu 1987;22:347-386.
5. Arnold MM, Wallace AC, Kreel L, Li MKW. Demonstration of lipiodol in paraffin sections using a modified silver impregnation technique. Am J Clin Pathol 1990;94:585-589.
6. Ferrell LD, Crawford JM, Dhillon AP, Scheuer PJ, Nakanuma Y. Proposal for standardized criteria for the diagnosis of benign, borderline and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993;17:1113-1123.
7. Nakanuma Y, Ohta G. Small hepatocellular carcinoma containing many Mallory bodies. Liver 1984;4:128-133.
8. Bhattacharya S, Dhillon AP, Winslet MC, Davidson BR, Datta Gupta S, Shukla N, A1-Mufti R, et al. Human liver cancer cells and endothelial cells incorporate iodised oil. Br J Cancer 1996;73:877-881.
9. Ibukuro K, Fukuda H, Mon K, Sato S, Inoue Y, Fujino H, Uta Y, et al. Lipiodol CT for the detection of small hypovascular HCC. Jpn J Clin Radiol 1990;35:1011-1014.
10. Bhattacharya S, Davidson BR, Dhillon AP. The blood supply of early hepatocellular carcinoma. Semin Liver Dis 1995;15:390-401.
11. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease [Review]. Nat Med 1995;1:27-31.
12. Castrucci M, Sironi S, Vanzulli A, Angeli E, Venturini M, Mellone R, Taccagni G, et al. Postoperative histologic evaluation of hepato-carcinoma treated using chemoembolisation. Radiol Med 1990;80:79-84.
13. Torimura T, Ueno T, Inuzuka S, Tanaka M, Abe H, Tanikawa K. Mechanism of fibrous capsule formation surrounding hepatocellular carcinoma: immunohistochemical study. Arch Pathol Lab Med 1991;115:895-903.
14. Enzan H, Himeno H, Iwamura S, Onishi S, Saibara T, Yamamoto Y, Hara H. Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma. HEPATOLOGY 1994;19:895-903.
15. Raoul J-L, Bourguet P, Bretagne J-F, Duvauferrier R, Coornaert S, Darnault P, Ramee A, et al. Hepatic artery injection of I-131-labelled lipiodol. Part I: Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology 1988;168:541-545.
16. Iwai K, Maeda H, Konno T. Use of oily contrast medium for selective drug targeting to tumour: enhanced therapeutic effect and x-ray image. Cancer Res 1984;44:2115-2121.
17. Motohashi I, Okudaira M, Takai T, Kaneko S, Ikeda N. Morphological differences between hepatocellular carcinoma and hepatocellular carcinoma-like lesions. HEPATOLOGY 1992;16:118-126.
18. Hsu H-C, Chiou T-J, Chen J-Y, Lee C-S, Lee P-H, Peng S-Y. Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. HEPATOLOGY 1991;13:923-928.
19. Aihara T, Noguchi S, Sasaki Y, Nakano H, Imaoka S. Clonal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis. Gastroenterology 1994;107:1805-1811.
20. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver: observations in five cases. Gastroenterology 1986;91:198-208.