A new route to the antitumour drug temozolomide, but not thiotemozolomide

Chemical Communications

Volumn , Issue 4, 1997, Pages 363-364

  Wang, Yongfeng ^a,b   Lowe, Philip R ^b   Thomson, William T ^c   Clark, Jonathan ^a   Stevens, Malcolm F G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTON UNIVERSITY   (United Kingdom)

^c Aston Molecules Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE; ANTINEOPLASTIC AGENT; ISOCYANIC ACID DERIVATIVE; METHYL ISOCYANATE; TEMOZOLOMIDE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; NITROSATION;

EID: 0031043640     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/a606159a     Document Type: Article

References (11)

1. S. M. O'Reilly, E. S. Newlands, M. G. Glaser, M. Brampton, J. M. Rice-Edwards, R. D. Illingworth, P. G. Richards, C. Kennard, I. R. Colquhoun, P. Lewis and M. F. G. Stevens, Eur. J. Cancer, 1993, 29A, 940.
2. N. M. Bleehen, E. S. Newlands, S. M. Lee, N. Thatcher, P. Selby, A. H. Calvert, G. J. S. Rustin, M. Brampton and M. F. G. Stevens, J. Clin. Oncol., 1995, 13, 910.
3. M. F. G. Stevens, J. A. Hickman, R. Stone, N. W. Gibson, G. U. Baig, E. Lunt and C. G. Newton, J. Med. Chem., 1984, 27, 196.
4. G. Ege and K. Gilbert, Tetrahedron Lett., 1979, 4253.
5. Y. Wang, M. F. G. Stevens, W. T. Thomson and B. P. Schutts, J. Chem. Soc., Perkin Trans. 1, 1995, 2783.
6. G. Ege, K. Gilbert and K. Maurer, Chem. Ber., 1987, 120, 1375.
7. J. G. Erickson, in The Chemistry of Heterocyclic Compounds, ed. J. G. Erickson, P. F. Wiley and V. P. Wystrach, Interscience Publishers, Inc., New York, 1956, vol. 10, pp. 1-43; M. F. G. Stevens, Progr. Med. Chem., 1976, 13, 205.
8. J. G. Erickson, in The Chemistry of Heterocyclic Compounds, ed. J. G. Erickson, P. F. Wiley and V. P. Wystrach, Interscience Publishers, Inc., New York, 1956, vol. 10, pp. 1-43; M. F. G. Stevens, Progr. Med. Chem., 1976, 13, 205.
9. C. C. Beard, USP 3 979 404/1976 (Chem. Abstr., 1977, 86, P29815).
10. G. M. Sheldrick, SHELX86, Program for Crystal Structure Solution, Ada Crystallogr., Sect. A, 1990, 46, 467.
11. G. M. Sheldrick, SHELX93, University of Göttingen, Germany, 1993.