Hypoxic pulmonary vasoconstriction in human lungs: A stimulus-response study

Anesthesiology

Volumn 86, Issue 2, 1997, Pages 308-315

  Hambraeus Jonzon, Kristina ^b   Bindslev, Lars ^c   Mellgård, Åse Jolin ^c   Hedenstierna, Göran ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NONE

Author keywords

Anesthetics: intravenous; Lung(s): hyperoxia, hypoxia; individual pulmonary blood flow; stimulus response; Measurement technique: inert gas exchange

Indexed keywords

MIDAZOLAM; MORPHINE; PANCURONIUM BROMIDE; SCOPOLAMINE; SULFUR HEXAFLUORIDE; THIOPENTAL;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEART OUTPUT; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; HYPOXIA; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS ANESTHESIA; INTRAVENOUS DRUG ADMINISTRATION; LUNG ALVEOLUS OXYGEN TENSION; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG PERFUSION; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; LUNG VENTILATION; MALE; PRIORITY JOURNAL; STIMULUS RESPONSE;

ADOLESCENT; ADULT; ANOXIA; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0031043271     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199702000-00006     Document Type: Article

References (32)

1. von Euler US, Liljestrand G: Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 1946; 12:301-20
2. Arborelius M Jr: Respiratory Gases and Pulmonary Blood Flow. A Bronchospirometric Study. Malmö, Landby & Lundgrens Boktryckeri, 1966
3. Marshall BE, Marshall C, Frasch F, Hanson CW: Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution. 1. Physiologic concepts. Intensive Care Med 1994; 20:291-7
4. Barer GR, Howard P, Shaw JW: Stimulus-response curves for the pulmonary vascular bed to hypoxia and hypercapnia. J Physiol 1970; 211:139-55
5. Marshall BE, Clarke WR, Costarino AT, Chen L, Miller F, Marshall C: The dose-response relationship for hypoxic pulmonary vasoconstriction. Respir Physiol 1994; 96:231-47
6. Marshall C, Marshall BE: Characterization of the stimulus-response curve for hypoxic pulmonary vasoconstriction. Pflygers Arch 1983; 398:93-5
7. Custer JR, Hales CA: Influence of alveolar oxygen on pulmonary vasoconstriction in newborn lambs versus sheep. Am Rev Respir Dis 1985; 132:326-31
8. Sylvester JT, Harabin AL, Peake MD, Frank RS: Vasodilator and constrictor responses to hypoxia in isolated pig lungs. J Appl Physiol 1980; 49:820-5
9. Nunn JF: Applied Respiratory Physiology. London, Butterworth, 1987, p 128
10. Van De Water JM, Kagey KS, Miller IT, Parker DA, O'Connor NE, Shell JM, MacArthur JD, Zollinger RM, Moore FD: Response of the lung to six to 12 hours of 100 per cent oxygen inhalation in normal man. N Engl J Med 1970; 283:621-6
11. Robinson SM, Cadwallader JA, Hill PMcN: Regional alveolar gas composition and lung function in sheep. Respir Physiol 1979; 37:239-54
12. Freeman BA, Topolosky MK, Crapo JD: Hyperoxia increases oxygen radical production in rat lung homogenates. Arch Biochem Biophys 1982; 216:10986-92
13. Tate RM, Morris HG, Schroeder WR, Repine JE: Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. J Clin Invest 1984; 74:608-13
14. Sanderud J, Saugstad OD: Oxygen radicals induce pulmonary vasoconstriction in pigs without activating plasma proteolytic cascade systems. But Surg Res 1993; 25:137-45
15. Wagner PD, Naumann PF, Laravuso RB: Simultaneous measurement of eight foreign gases in blood by gas chromatography. J Appl Physiol 1974; 36:600-5
16. 2. J Clin Invest 1974; 54:54-68
17. 2 elimination. ANESTHESIOLOGY 1987; 67:240-6
18. Bindslev L, Carlsson Å Jolin, Hedenstierna G, Baehrendtz S, Santesson J: Hypoxic pulmonary vasoconstriction in the human lung: Effect of repeated hypoxic challenges during anesthesia. ANESTHESIOLOGY 1985; 62:621-5
19. Carlsson Å Jolin, Bindslev L, Santesson J, Gottllieb I, Hedenstierna G: Hypoxic pulmonary vasoconstriction in the human lung: The effect of prolonged unilateral hypoxic challenge during anaesthesia. Acta Anaesthesiol Scand 1985; 29:346-51
20. Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; Feb 8:307-10
21. Marshall BE, Marshall C: Continuity of response to hypoxic pulmonary vasoconstriction. J Appl Physiol 1980; 49:189-96
22. Marshall C, Marshall BE: Site and sensitivity for stimulation of hypoxic pulmonary vasoconstriction. J Appl Physiol 1983; 55:711-16
23. 2. Acta Physiol Scand 1969; 76:121-30
24. 2 on hypoxic pulmonary vasoconstriction. J Appl Physiol 1981; 51:871-4
25. 2 on pulmonary vascular resistance. J Appl Physiol 1991; 70:405-15
26. Unger M, Atkins M, Briscoe WA, King TKC: Potentiation of pulmonary vasoconstrictor response with repeated intermittent hypoxia. J Appl Physiol 1977; 43:662-7
27. Pirlo AF, Benumof JL, Trousdale FR: Potentiation of lobar hypoxic pulmonary vasoconstriction by intermittent hypoxia in dogs. ANESTHESIOLOGY 1981; 55:226-30
28. Benumof JL: Intermittent hypoxia increases lobar hypoxic pulmonary vasoconstriction. ANESTHESIOLOGY 1983; 58:399-404
29. Chen L, Miller FL, Williams JJ, Alexander CM, Domino KB, Marshall C, Marshall BE: Hynoxic pulmonary vasoconstriction is not potentiated by repeated intermittent hypoxia in closed chest dogs. ANESTHESIOLOGY 1985; 63:608-10
30. Cutaia M, Rounds S: Hypoxic pulmonary vasoconstriction. Physiologic significance, mechanism, and clinical relevance. Chest 1990; 97:706-18
31. Domino KB, Chen L, Alexander CM, Williams JJ, Marshall C, Marshall BE: Time course and responses of sustained hypoxic pulmonary vasoconstriction in the dog. ANESTHESIOLOGY 1984; 60:562-6
32. Vejlstrup NG, Dorrington KL: Intense slow hypoxic pulmonary vasoconstriction in gas-filled and liquid-filled lungs: An in vivo study in the rabbit. Acta Physiol Scand 1993; 148:305-13