Role of metabolites in aviation forensic toxicology

Aviation Space and Environmental Medicine

Volumn 68, Issue 3, 1997, Pages 230-233

  Chaturvedi, Arvind K ^a,b   Canfield, Dennis V ^a  

^a U S DEPARTMENT OF TRANSPORTATION   (United States)

^b CIVIL AEROSPACE MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DIAZEPAM; DRUG METABOLITE; OXAZEPAM; TEMAZEPAM; TERFENADINE;

ARTICLE; DIAGNOSTIC ACCURACY; DRUG DETERMINATION; DRUG METABOLISM; FLIGHT; FORENSIC MEDICINE; TOXICOLOGY;

ACCIDENTS, AVIATION; AEROSPACE MEDICINE; BIOTRANSFORMATION; FORENSIC MEDICINE; HUMANS; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS;

EID: 0031043246     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Abe T, Watanabe M. Genetic differences in the induction of aryl hydrocarbon hydroxylase and its components by 3-methylcholanthrene in liver and lung microsomes among four strains of guinea pigs. Biochem Pharmacol 1982; 31:2077-82.
2. Bailey DN. Studies of cocaethylene (ethylcocaine) formation by human tissues in vitro. J Anal Toxicol 1994; 18:13-5.
3. Baselt RC, Cravey RH, eds. Disposition of toxic drugs and chemicals in man, 4th ed. Foster City, CA: Chemical Toxicology Institute, 1995.
4. Canfield DV, Flemig J, Hordinsky JR, Veronneau SJH. Unreported medications used in incapacitating medical conditions found in fatal civil aviation accidents. Aviat Space Environ Med 1994; 65:455.
5. Chaturvedi AK, Kuntz DJ. Interaction between phencyclidine and its pyrolysis product, 1-phenylcyclohexene. Pharmacol Biochem Behav 1988; 30:1035-43.
6. Chaturvedi AK, Kuntz DJ, Rao NGS. Metabolic aspects of the toxicology of mixtures of parathion, toxaphene and/or 2,4-D in mice. J Appl Toxicol 1991; 11:245-51.
7. Chaturvedi AK, Rao NGS, Hurley MP. Toxicological findings in a multi-drug death involving propoxyphene, caffeine, phenacetin, acetaminophen and salicylate. Forensic Sci Int 1983; 23:255-64.
8. Chaturvedi AK, Rao NGS, McCoy FE. A multi-chemical death involving caffeine, nicotine and malathion. Forensic Sci Int 1983; 23:265-75.
9. Dean RA, Harper ET, Dumaual N, et al. Effects of ethanol on cocaine metabolism: Formation of cocaethylene and norcocaethylene. Toxicol Appl Pharmacol 1992; 117:1-8.
10. Dieterle W, Faigle JW. Preparative liquid-chromatographic methods in drug metabolism studies. In: Reid E, Leppard JP, eds. Drug metabolite isolation and determination. New York, NY: Plenum Press, 1983:13-32.
11. Evans MA, Baselt RC. Principles of toxic disposition. In: Cravey RH, Baselt RC, eds. Introduction to forensic toxicology. Davis, CA: Biomedical Publications, 1981:41-68.
12. Finkle BS, McCloskey KL, Kiplinger GF, Bennett IF. A national assessment of propoxyphene in postmortem medicolegal investigation, 1972-1975. J Forensic Sci 1976; 21:706-42.
13. Foltz RL, Fentiman Jr. AF, Foltz RB. GC/MS assays for abused drugs in body fluids. Rockville, MD: U.S. Department of Health and Human Services, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse. 1980 August. Research Monograph 32.
14. Freeman AS, Martin BR. Quantification of phencyclidine in mainstream smoke and identification of phenylcyclohex-1-ene as pyrolysis product. J Pharm Sci 1981; 70:1002-4.
15. Gillette JR, Jollow DJ. Drug metabolism in liver. In: Becker FF, ed. The liver, part A. New York, NY: Marcel Dekker, Inc., 1974:165-201.
16. Henderson G. Phencyclidine, a widely abused but little understood psychotomimitic agent. Trends Pharmacol Sci 1982; 3:248-50.
17. Hu CY, Choudhuri MSK, Berg IE, et al. Toxicity of 1-phenylcyclohexene and its interaction with phencyclidine. Toxicol Appl Pharmacol 1984; 76:403-13.
18. 9-tetrahydrocannabinol (THCCOOH). J Anal Toxicol 1992; 16:283-9.
19. McBay AJ. Propoxyphene. In: Sunshine I, ed. Methodology for analytical toxicology. West Palm Beach, FL: CRC Press, Inc., 1978:322-4.
20. Nelson SD. Metabolic activation and drug toxicity. J Med Chem 1982; 25:753-65.
21. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes: I. Evidence for its hemoprotein nature. J Biol Chem 1964; 239:2370-8.
22. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes: II. Solubilization, purification, and properties. J Biol Chem 1964; 239:2379-85.
23. Overton M, Hickman JA, Threadgill MD, et al. The generation of potentially toxic reactive iminium ions from the oxidative metabolism of xenobiotic N-alkyl compounds. Biochem Pharmacol 1985; 34:2055-61.
24. Petersen RC. Marihuana research findings: 1980. Rockville, MD: U.S. Department of Health and Human Services, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse. 1980 June. Research Monograph 31.
25. Petersen RC, Stillman RC. Phencyclidine (PCP) abuse: an appraisal. Rockville, MD: U.S. Department of Health and Human Services, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse. 1978 August. Research Monograph 21.
26. Sipes IG, Gandolfi AJ. Biotransformation of toxicants. In: Amdur MO, Doull J, Klaassen CD, eds. Casarett and Doull's toxicology: the basic science of poisons, 4th ed. New York, NY: Pergamon Press, 1991:88-126.
27. Skellern GG. Strategies centered on HPLC. In: Reid E, Leppard JP, eds. Drug metabolite isolation and determination. New York, NY: Plenum Press, 1983:3-11.
28. White VL, Canfield DV, Hordinsky JR. The identification and quantitation of triamterene in blood and urine from a fatal aircraft accident. Washington, DC: U.S. Department of Transportation, Federal Aviation Administration. 1992 July. Report No.: DOT/ FAA/AM-92/23.
29. Williams RT. Detoxification mechanisms. New York, NY: Wiley, 1959.
30. Zimmerman HJ. Hepatic metabolism of foreign compounds. In: Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver, chapter 2. New York, NY: Appleton-Century-Crofts, 1978:11-31.