Cytotoxicity of radiocontrast agents on polarized renal epithelial cell monolayers

Cardiovascular Research

Volumn 33, Issue 3, 1997, Pages 655-665

  Haller, Christlieb ^a   Schick, Cornelia S ^a   Zorn, Markus ^a   Kübier, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

LLCPK; MDCK; Nephrotoxicity; Osmolality; Permeability; Polarity

Indexed keywords

DIATRIZOATE; IOPAMIDOL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOG; EPITHELIUM; NEPHROTOXICITY; NONHUMAN; OSMOLALITY; PRIORITY JOURNAL; SWINE;

ANIMALS; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CELL SURVIVAL; CONTRAST MEDIA; DIATRIZOATE; DOGS; EPITHELIAL CELLS; EPITHELIUM; INULIN; IOPAMIDOL; KIDNEY TUBULES; MANNITOL; OSMOLAR CONCENTRATION;

EID: 0031042821     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(96)00264-7     Document Type: Article

References (29)

1. Barrett BJ, Parfrey PS, Vavasour HM, et al. Contrast nephropathy in patients with impaired renal function: high versus low osmolar media. Kidney Int 1992;41:1274-1279.
2. Rudnick MR, Goldfarb S, Wexler L, et al. Nephrotoxicity of ionic and nonionic contrast media in 1196 patients: a randomized trial. Kidney Int 1995;47:254-261.
3. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute contrast nephropathy after coronary intervention: incidence, risk factors, and relationship to mortality. J Am Coll Cardiol 1996;27:304A(Abstract).
4. Berns AS. Nephrotoxicity of contrast media. Kidney Int 1989;36:730-740.
5. Brezis M, Epstein FH. A closer look at radiocontrast-induced nephropathy. New Engl J Med 1989;320:179-181.
6. Humes HD, Hunt DA, White MD. Direct toxic effect of the radiocontrast agent diatrizoate on renal proximal tubule cells. Am J Physiol 1987;252:F246-F255.
7. Messana JM, Cieslinski DA, Nguyen VD, Humes HD. Comparison of the toxicity of the radiocontrast agents, iopamidol and diatrizoate, to rabbit renal proximal tubule cells in vitro. J Pharmacol Exp Ther 1988;244:1139-1144.
8. Andersen K-J, Christensen EI, Vik H. Effects of iodinated X-ray contrast media on renal epithelial cells in culture. Invest Radiol 1994;11:955-962.
9. Rodriguez-Boulan E, Nelson J. Morphogenesis of the polarized epithelial phenotype. Science 1989;245:718-725.
10. Nelson WJ. Renal epithelial cell polarity. Curr Opin Nephrol Hypertens 1992;1:59-67.
11. Fish EM, Molitoris BA. Alterations in epithelial polarity and the pathogenesis of disease states. N Engl J Med 1994;330:1580-1588.
12. Ojakian GK, Romain RE, Herz RE. A distal nephron glycoprotein that has different cell surface distributions on MDCK cell sublines. Am J Physiol 1987;253:C433-C443.
13. Rabito CA. Occluding junctions in a renal cell line (LLC-PK1) with characteristics of proximal tubular cells. Am J Physiol 1986;19:F734-743.
14. Ojakian GK, Schwimmer R. The polarized distribution of an apical cell surface glycoprotein is maintained by interactions with the cytoskeleton of Madin-Darby canine kidney cells. J Cell Biol 1988;107:2377-2387.
15. Herzlinger DA, Ojakian GK. Studies on the development and maintenance of epithelial cell surface polarity with monoclonal antibodies. J Cell Biol 1984;98:1777-1787.
16. Schwab SJ, Hlatky MA, Pieper KS, et al. Contrast nephrotoxicity: a randomized controlled trial of a nonionic and an ionic radiographic contrast agent. N Engl J Med 1989;320:149-153.
17. Barrett BJ, Carlisle EJ. Metaanalysis of the relative nephrotoxicity of high and low-osmolality iodinated contrast media. Radiology 1993;188:171-178.
18. Brezis M, Greenfeld Z, Herrman M, Meyer JJ, Heyman SN, Rosen S. Experimental nephrotoxicity of the radiocontrast agents iohexol, ioxaglate, and iothalamate. An in vitro and in vivo study. Invest Radiol 1991;26:325-331.
19. Heyman SN, Clark BA, Cantley L, et al. Effects of ioversol versus iothalamate on endothelin release and radiocontrast nephropathy. Invest Radiol 1993;28:313-318.
20. Cohen DM, Wassermann JC, Gullans SR. Immediate early gene and HSP 70 expression in hyperosmotic stress in MDCK cells. Am J Physiol 1991;261:c594-601.
21. Older RA, Korobkin M, Cleeve DM, Schaaf R, Thompson W. Contrast induced acute renal failure: persistent nephrogram as clue to early detection. Am J Roentgenol 1980;134:339-342.
22. Spataro RF, Fischer HW, Boylan L. Urography with low-osmolality contrast media: comparative urinary excretion of iopamidol, hexabrix, and diatrizoate. Invest. Radiol 1984;19:353-359.
23. Agmon Y, Peleg H, Greenfeld Z, Rosen S, Brezis M. Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat. J Clin Invest 1994;94:1069-1075.
24. Cantley LG, Spokes K, Clark B, McMahon EG, Carter J, Epstein FH. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney Int 1993;44:1217-1223.
25. Brezis M, Rosen S. Hypoxia of the renal medulla - its implications for disease. New Engl J Med 1995;332:647-655.
26. Heyman SN, Brezis M, Epstein FH, Spokes K, Silva P, Rosen S. Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 1991;40:632-642.
27. Thadhani R, Pascual M, Bonventre J. Acute renal failure. N Engl J Med 1996;334:1448-1460.
28. Molitoris BA, Nelson WJ. Alterations in the establishment and maintenance of epithelial cell polarity as a basis for disease processes. J Clin Invest 1990;85:3-9.
29. Wilson PD, Sherwood AC, Palla KJD, Watson R, Norman JT. Reversed polarity of Na/K-ATPase: mislocalization to the apical plasma membranes in polycystic kidney disease epithelia. Am J Physiol 1991;260:F420-F430.