The Mycoplasma hominis P120 membrane protein contains a 216 amino acid hypervariable domain that is recognized by the human humoral immune response

Microbiology

Volumn 143, Issue 2, 1997, Pages 675-688

  Nyvold, Charlotte ^a,b   Birkelund, Svend ^a   Christiansen, Gunna ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

120 kDA antigen; Antigenic variation; Membrane protein; Mycoplasma hominis

Indexed keywords

ANTIBODY; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY;

ANTIGENIC VARIATION; ARTICLE; DNA SEQUENCE; EXPRESSION VECTOR; GENETIC VARIABILITY; GRAM NEGATIVE INFECTION; HUMORAL IMMUNITY; IMMUNOBLOTTING; MOLECULAR CLONING; MYCOPLASMA HOMINIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ESCHERICHIA COLI; MYCOPLASMA HOMINIS; MYCOPLASMATALES; NEGIBACTERIA;

EID: 0031042409     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-2-675     Document Type: Article

References (34)

1. Andersen, H., Birkelund, S., Christiansen, G. & Freundt, E. A. (1987). Electrophoretic analysis of proteins from Mycoplasma hominis strains detected by SDS-PAGE, two-dimensional gel electrophoresis and immunoblotting. J Gen Microbiol 133, 181-191.
2. Birkelund, S. & Andersen, H. (1988). Comparative studies of mycoplasma antigens and corresponding antibodies. In Handbook of Immunoblotting of Proteins, vol. II, pp. 25-33. Edited by O. J. Bjerrum & N. H. H. Heegaard. Boca Raton, FL: CRC Press.
3. Blanchard, A., Yáñez, A., Dybvig, K., Watson, H. L., Griffiths, G. & Cassell, G. H. (1993). Evaluation of intraspecies genetic variation within the 16S rRNA gene of Mycoplasma hominis and detection by polymerase chain reaction. J Clin Microbiol 31, 1358-1361.
4. Brown, M. B., Minion, F. C., Davis, J. K., Pritchard, D. G. & Cassell, G. H. (1983). Antigens of Mycoplasma hominis. Sex Transm Dis 10 (Suppl.), 247-255.
5. Chomczynski, P. & Sacchi, N. (1987). Single-step method for isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156-159.
6. Christiansen, G. & Andersen, H. (1988). Heterogeneity among Mycoplasma hominis strains as detected by probes containing parts of ribosomal ribonucleic acid genes. Int J Syst Bacteriol 38, 108-115.
7. Christiansen, G., Ladefoged, S., Hauge, S., Birkelund, S. & Andersen, H. (1990). Use of monoclonal antibodies for detection of gene and antigen variation in Mycoplasma hominis. In Recent Advances in Mycoplasmology, pp. 535-545. Edited by G. Stanek, G. H. Cassell, J. G. Tully & R. F. Whitcomb. Stuttgart: Gustav Fisher.
8. Christiansen, G., Mathiesen, S. L., Nyvold, C. & Birkelund, S. (1994). Analysis of a Mycoplasma hominis membrane protein, P120. FEMS Microbiol Lett 121, 121-128.
9. Devereux, J., Haerberli, P. & Smithies, O. (1984). A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12, 387-395.
10. Feldmann, R. C., Henrich, B., Kolb-Bachofen, V. & Hadding, U. (1992). Decreased metabolism and viability of Mycoplasma bominis induced by monoclonal antibody-mediated agglutination. Infect Immun 60, 166-174.
11. Grau, O., Laigret, F., Carle, P., Tully, J. G., Rose, D. L. & Bove, J. M. (1991). Identification of a plant-derived mollicute as a strain of an avian pathogen, Mycoplasma iowae, and its implications for mollicute taxonomy. Int J Syst Bacteriol 41, 473-478.
12. von Heijne, G. (1989). The structure of signal peptides from bactrial lipoproteins. Protein Eng 2, 531-534.
13. Hollingdale, M. R. & Lemcke, R. (1970). Antigenic differences within the species Mycoplasma hominis. J Hyg 68, 469-477.
14. Krause, D. C. & Taylor-Robinson, D. (1992). Mycoplasmas which infect humans. In Mycoplasmas, Molecular Biology and Pathogenesis, pp. 417-444. Edited by J. Maniloff, R. N. McElhaney, L. R. Finch & J. B. Baseman. Washington, DC: American Society for Microbiology.
15. Ladefoged, S. A. & Christiansen, G. (1992). Physical and genetic mapping of the genomes of five Mycoplasma hominis strains by pulsed-field gel electrophoresis. J Bacteriol 174, 2199-2207.
16. Ladefoged, S., Hauge, S., Andersen, H., Birkelund, S. & Christiansen, G. (1990). Use of monoclonal antibodies for detection of antigen variation in Mycoplasma hominis. In Recent Advances in Mycoplasmology, pp. 634-639. Edited by G. Stanek, G. H. Cassell, J. G. Tully & R. F. Whitcomb. Stuttgart: Gustav Fisher.
17. McClenaghan, M., Herring, A. J. & Aitken, I. D. (1984). Comparison of Chlamydia psittaci isolates by DNA restriction endonuclease analysis. Infect Immun 45, 384-389.
18. Olson, L. D., Shane, S. W., Karpas, A. A., Cunningham, T. M., Probst, P. S. & Barile, M. F. (1991). Monoclonal antibodies to surface antigens of a pathogenic Mycoplasma hominis strain. Infect Immun 59, 1683-1689.
19. Peterson, S. N., Bailey, C. C., Jensen, J. S., Borre, M. B., Klng, E. S., Bott, K. F. & Hutchison III, C. A. (1995). Characterization of repetitive DNA in the Mycoplasma genitalium genome: possible role in the generation of antigenic variation. Proc Natl Acad Sci USA 92, 11829-11833.
20. Razin, S. & Freundt, E. A. (1984). The mycoplasmas. In Bergey's Manual of Systematic Bacteriology, vol. 1, pp. 740-793. Edited by N. R. Krieg & J. G. Holt. Baltimore: Williams & Wilkins.
21. Ruland, K., Himmelreich, R. & Hermann, R. (1994). Sequence divergence in the ORF6 gene of Mycoplasma pneumoniae. J Bacteriol 176, 5202-5209.
22. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
23. Sanger, F., Nicklen, S. & Coulson, A. R. (1977). DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74, 5463-5467.
24. Sasaki, T., Sasaki, Y., Matsumura, T., Oyama, N. & Koshimizu, K. (1989). Characterization of a strain of Mycoplasma hominis lacking 120 kDa membrane protein isolated from a Vero cell culture. Microbiol Immunol 33, 423-427.
25. Simmons, W. L., Zuhua, C., Glass, J. L., Simecka, J. W., Cassell, G. H. & Watson, H. L. (1996). Sequence analysis of the chromosomal region around and within the V-1-encoding gene of Mycoplasma pulmonis: evidence for DNA inversion as a mechanism for V-1 variation. Infect Immun 64, 472-479.
26. Southern, E. M. (1975). Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98, 503-517.
27. Su, C. J. & Baseman, J. B. (1990). Genome size of Mycoplasma genitalium. J Bacteriol 172, 4705-4707.
28. Su, C. J., Dallo, S. F., Chavoya, A. & Baseman, J. B. (1993). Possible origin of sequence divergence in the P1 cytadhesin gene of Mycoplasma pneumoniae. Infect Immun 61, 816-822.
29. Taylor-Robinson, D., Somerson, N. L., Turner, H. C. & Chanock, R. M. (1963). Serological relationships among human mycoplasms as shown by complement-fixation and gel diffusion. J Bacteriol 85, 1261-1273.
30. Thomasen, A. C. (1978). Mycoplasmas in human pyelonephritis: demonstration of antibodies in serum and urine. J Clin Microbiol 8, 197-202.
31. Tully, J. G. (1983). Cloning and filtration techniques for mycoplasmas. In Methods in Mycoplasmology, vol. 1, pp. 173-177. Edited by S. Razin & J. G. Tully. New York: Academic Press.
32. Tully, J. G. (1993). Mollicutes: Mycoplasma pneumoniae and Mycoplasma genitalium. Current status of the Mollicute flora of humans. Clin Infect Dis 17 (Suppl. 1), S2-S9.
33. Yamao, F., Muto, A., Kawauchi, Y., Iwami, M., Iwagami, S., Azumi, Y. & Osawa, S. (1985). UGA is read as tryptophan in Mycoplasma capricolum. Proc Natl Acad Sci USA 82, 2306-2309.
34. Yogev, D., Watson-McKown, R., Rosengarten, R., Im, J. & Wise, K. (1995). Increased structural and combinatorial diversity in an extended family of genes encoding VIp surface proteins of Mycoplasma hyorhinis. J Bacteriol 177, 5636-5643.