Tumor cell counting using an image analysis program for MIB-1 immunohistochemistry

Neurologia Medico-Chirurgica

Volumn 37, Issue 2, 1997, Pages 158-162

  Ide, Mitsunobu ^a   Jimbo, Minoru ^a   Yamamoto, Masaaki ^a   Kubo, Osami ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

brain neoplasms; growth fraction; image analysis; immunohistochemistry; MIB 1; NIH Image

Indexed keywords

MONOCLONAL ANTIBODY KI 67;

ARTICLE; BRAIN TUMOR; CANCER CELL; CELL COUNT; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY;

EID: 0031042212     PISSN: 03872572     EISSN: None     Source Type: Journal    
DOI: 10.2176/nmc.37.158     Document Type: Article

References (20)

1. Bacus SS, Goldschmidt R, Chin D, Moran G, Weinberg D, Bacus JW: Biological grading of breast cancer using antibodies to proliferating cells and other markers. Am J Pathol 135: 783-792, 1989
2. Benjamin DR: Proliferating nuclear antigen (PCNA) and pediatric tumors: Assessment of proliferative activity. Pediatr Pathol 11: 507-519, 1991
3. Caulet S, Lesty C, Raphael M, Schoevaert D, Brousset P, Binet J-L, Diebold J, Delsol G: Comparative quantitative study of Ki-67 antibody staining in 78 B and T cell malignant lymphoma (ML) using two image analyser systems. Pathol Res Pract 188: 490-496, 1992
4. Ellison DW, Steart PV, Bateman AC, Pickering RM, Palmer JD: Prognostic indicators in a range of astrocytic tumours: An immunohistochemical study with Ki-67 and p53 antibodies. J Neurol Neurosurg Psychiatry 59: 413-419, 1995
5. Franklin WA, Bibbo M, Doria MI: Quantitation of estrogen receptor content and Ki-67 staining in breast carcinoma by the MicroTI-CAS image analysis system. Anal Quant Cytol Histol 9: 279-286, 1987
6. Fujimaki T, Matsutani M, Nakamura O, Asai A, Funada N, Koike M, Segawa H, Aritake K, Fukushima T, Houjo S, Tamura A, Sano K: Correlation between bromodeoxyuridine-labeling indices and patient prognosis in cerebral astrocytic tumors of adults. Cancer 67: 1629-1634, 1991
7. Fukui M, Iwaki T, Sawa H, Inoue T, Takeshita I, Kitamura K: Proliferative activity of meningiomas as evaluated by bromodeoxyuridine uptake examination. Acta Neurochir (Wien) 81: 135-141, 1986
8. Hopf NJ, Bremm J, Bohl J, Perneczky A: Image analysis of proliferating cells in tumors of the human nervous system: An immunohistological study with the monoclonal antibody Ki-67. Neurosurgery 35: 917-923, 1994
9. Hoshino T, Prados M, Wilson CB, Cho KG, Lee K-S, Davis RL: Prognostic implications of the bromodeoxyuridine labeling index of human gliomas. J Neurosurg 71: 335-341, 1989
10. Ide M, Jimbo M, Yamamoto M, Umebara Y, Hagiwara S, Kubo O: Growth rate of intracranial meningioma: Tumor doubling time and proliferating cell nuclear antigen staining index. Neurol Med Chir (Tokyo) 35: 289-293, 1995
11. Ide M, Jimbo M, Yamamoto M, Umebara Y, Hagiwara S, Kubo O: MIB-1 staining index and peritumoral brain edema of meningiomas. Cancer 78: 133-143, 1996
12. Rasband W: Analyze; menu, in: NIH Image, Ver. 1.59 Manual. 1995, pp 36-43
13. Sallinen PK, Haapasalo HK, Visakorpi T, Helén PT, Rantala IS, Isola JJ, Helin HJ: Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples. J Pathol 174: 275-282, 1994
14. Schwarz BR, Pinkus G, Bacus S, Toder M, Weinberg DS: Cell proliferation in non-Hodgkin's lymphomas: Digital analysis of Ki-67 antibody staining. Am J Pathol 134: 327-336, 1989
15. Shibuya M, Hoshino T, Ito S, Wacker MR, Prados MD, Davis RL, Wilson CB: Meningiomas: Clinical implications of a high proliferative potential determined by bromodeoxyuridine labeling. Neurosurgery 30: 494-498, 1992
16. Shinonaga M, Chang CC, Suzuki N, Sato M, Kuwabara T: Immunohistological evaluation of macrophage infiltrates in brain tumors: Correlation with peritumoral edema. J Neurosurg 68: 259-265, 1988
17. Simpson JF, Dutt PL, Page DL: Expression of mitoses per thousand cells and cell density in breast carcinomas. Hum Pathol 23: 608-611, 1992
18. Souchier C, French M, Berger F, Scoazec JY, Byron PA: Image analysis applied to proliferating cells in malignant lymphoma. Cytometry 9: 201-205, 1988
19. Wakimoto H, Aoyagi M, Nakayama T, Nagashima G, Yamamoto S, Tamaki M, Hirakawa K: Prognostic significance of Ki-67 labeling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas. Cancer 77: 373-380, 1996
20. Yamamoto M, Ide M, Umebara Y, Hagiwara S, Jimbo M, Takakura K: Gamma knife radiosurgery in brain tumors: Postirradiation volume changes compared with preradiosurgical growth fractions. Neurol Med Chir (Tokyo) 36: 358-363, 1996