Limited junctional diversity of Vδ5-Jδ1 rearrangement in multiple sclerosis patients

Molecular and Chemical Neuropathology

Volumn 30, Issue 1-2, 1997, Pages 95-100

  Nowak, Jerzy S ^a   Michałowska Wender, Grazyna ^b   Januszkiewicz, Danuta ^a   Wender, Mieczysław ^b  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

autoimmune disease; gene rearrangement; lymphocytes; Multiple sclerosis; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE REARRANGEMENT; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; T LYMPHOCYTE;

EID: 0031042017     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815152     Document Type: Article

References (14)

1. Beall S. S., Biddison W. E., McFarlin D. E., McFarland H. F., and Hood L. E. (1993) Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR V beta chain locus and HLA class II genes. J. Neuroimmunol. 45, 53-60.
2. Chou Y. K., Buenafe A. C., Dedrick R., Morrison W. J., Bourdette D. N., Whitham R., Atherton J., Lane J., Spoor E., and Hashim G. A. (1994) T cell receptor V beta gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis. J. Neurosci. Res. 37, 169-181.
3. ffrench-Constant C. (1994) Pathogenesis of multiple sclerosis. Lancet 343, 271-274.
4. Hata S., Clabby M., Devlin P., Spits H., De Vries J. E., and Krangel M.S. (1989) Diversity and organization of human T cell receptor delta variable gene segments. J. Exp. Med. 169, 41-57.
5. Hvas J., Oksenberg J. R., Fernando R., Steinman L., and Bernard C. C. (1993) Gamma delta T cell receptor repertoire in brain lesions of patients with multiple sclerosis. J. Neuroimmunol. 46, 225-234.
6. Joshi N., Usuku K., and Hauser S. L. (1993) The T-cell response to myelin basic protein in familial multiple sclerosis:diversity of fine specificity, restricting elements, and T-cell receptor usage. Ann. Neurol. 34, 385-393.
7. Loh E. Y., Cwirla S., Serafini A. T., Philips J. H., and Lanier L. L. (1989) Human T cell receptor delta chain: Genomic organisation, diversity, and expression in population of cells. Proc. Natl. Acad. Sci. USA 85, 9714-9718.
8. Oksenberg J. R., Panzara M. A., Begovich A. B., Michell D., Erlich H. A., Murray R. S., Shimonkevitz R., Sherritt M., Rothbard J., and Bernard C. C. (1993) Selection for T cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362, 68-70.
9. Sambrook J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
10. Shimonkevitz R., Colburn C., Burnham J. A., Murray R. S., and Kotzin B. L. (1993) Clonal expansion of activated gamma delta T cells in recent-onset multiple sclerosis. Proc. Natl. Acad. Sci. USA 90, 923-927.
11. Stinissen P., Vandevzver C., Medaer R., Vandegaer L., Nies J., Tuyls L., Hafler D. A., Raus J., and Zhang J. (1995) Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. J. Immunol. 154, 4883-4894.
12. Tienari P. J., Wikstrom J., Sajantila A., Palo J., and Peltonen L. (1992) Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene. Lancet 340, 987-991.
13. Wucherpfennig K. W., Newcombe J., Li H., Keddy C., Cuzner M. L., and Hafler D. A. (1992) Gamma delta T cell receptor repertoire in acute multiple sclerosis lesions. Proc. Natl. Acad. Sci. USA 89, 4588-4592.
14. Wucherpfennig, K. W., Zhang J., Witek C., Matsui M., Modabber Y., Ota K., and Hafler D. A. (1994) Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152, 5581-5592.