Chemotaxis by human neutrophils and their cytokineplasts treated with inhibitors of nitric oxide synthase: No suppression of orientation or trajectory

Journal of Leukocyte Biology

Volumn 61, Issue 1, 1997, Pages 58-62

  Malawista, Stephen E ^a   De Boisfleury Chevance, Anne ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

diphenyleneiodonium; N( ) methyl L arginine; N iminoethyl L ornithine

Indexed keywords

DIPHENYLIODONIUM SALT; N IMINOMETHYLORNITHINE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROSCOPY; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; TECHNIQUE;

EID: 0031041719     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.61.1.58     Document Type: Article

References (12)

1. Salvemini, D., de Nucci, G., Gryglewski, R. J., Vane, J. R. (1989) Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc. Natl. Acad. Sci. USA 86, 6328-6332.
2. ω-monomethyl-L-arginine: a role for cyclic GMP. Blood 74, 1885-1887.
3. Kubes, P., Suzuki, M., Granger, D. N. (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88, 4651-4655.
4. Malawista, S. E., Montgomery, R. R., Van Blaricom, G. (1992) Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts: a new microbicidal pathway for polymorphonuclear leukocytes. J. Clin. Invest. 90, 631-636.
5. Malawista, S. E., Montgomery, R. R., Van Blaricom, G. (1996) Microbial killing by human neutrophil cytokineplasts: similar suppressive effects of reversible and irreversible inhibitors of nitric oxide synthase. J. Leukoc. Biol., in press.
6. McCall, T, B., Feelish, M., Palmer, R. M. J., Moncada, S. (1991) Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br. J. Pharmacol. 102, 234-238.
7. Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R., Nathan, C. F. (1991) Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J. 5, 98-103.
8. Belenky, S. N., Robbins, R. A., Rennard, S. I., Gossman, G. L., Nelson, K. J., Rubinstein, I. (1993) Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro. J. Lab. Clin. Med. 122, 388-394.
9. Bessis, M. (1973) Une forme particuliere de chimiotaxis: le necrotaxis. Nouv. Rev. Fr. Hematol. 13, 285-290.
10. Malawista, S. E., de Boisfleury Chevance, A. (1991) Cryopreserved cytoplasts from human polymorphonuclear leukocytes (cytokineplasts) are chemotactic at speeds comparable to those of fresh intact cells. J. Leukoc. Biol. 50, 313-315.
11. Malawista, S. E., de Boisfleury Chevance, A. (1982) The cytokineplast: purified, stable, and functional motile machinery from human blood polymorphonuclear leukocytes. J. Cell Biol. 95, 960-973.
12. Kanwar, S., Kubes, P. (1995) Nitric oxide is an antiadhesive molecule for leukocytes. New Horizons 3, 93-104.