The effect of α-trinositol (D-myo-inositol 1,2,6-trisphosphate) on formalin-evoked spinal amino acid and prostaglandin E2 levels

Brain Research

Volumn 747, Issue 1, 1997, Pages 160-164

  Malmberg, Annika B ^a,b   Hedner, Thomas ^a   Fallgren, Bo ^a   Calcutt, Nigel A ^c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

trinositol; amino acid; antinociception; formalin test; prostaglandin E2; spinal microdialysis

Indexed keywords

AMINO ACID; FORMALDEHYDE; INOSITOL 1,2,6 TRISPHOSPHATE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; FEMALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

AMINO ACIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; DINOPROSTONE; FEMALE; FORMALDEHYDE; INOSITOL PHOSPHATES; MICRODIALYSIS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0031041490     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01299-1     Document Type: Article

References (43)

1. Adamsson, M. and Edvinsson L., Blockade of neuropeptide Y-induced potentiation of noradrenalin-evoked vasoconstriction by D-myo-inositol 1,2,6-trisphosphate (PP56) in rabbit femoral arteries, Neuropeptides, 19 (1991) 13-16.
2. Alosi, A.M., Porro, C.A., Cavazzuti, M., Baraldi, P. and Carli, G., "Mirror pain" in the formalin test: behavioral and 2-deoxyglucose studies, Pain, 55 (1993) 267-273.
3. Andreeva, L. and Rang, H.P., Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro, Br. J. Pharmacol., 108 (1993) 185-190.
4. Calcutt, N.A., Malmberg, A.B., Yamamoto, T. and Yaksh, T.L., Tolrestat treatment prevents modifications of the formalin test model of prolonged pain in hyperglycemic rats, Pain, 58 (1994) 413-420.
5. Carrington, A.L., Calcutt, N.A., Ettlinger, C.B., Gustafsson, T. and Tomlinson, D.R., Effects of treatments with myo-inositol or its 1,2,6-triphophate (PP56) on nerve conduction in streptozotocin-diabetes, Eur. J. Pharmacol., 237 (1993) 257-263.
6. Claxson, A., Morris, C., Blake, D., Sirén, M., Halliwell, Gustafsson, T., Löfkvist, B. and Bergelin, I., The anti-inflammatory effects of D-myo-inositol-1,2,6-trisphosphate (PP56) on animal models of inflammation, Agents Actions, 29 (1990) 68-70.
7. 2 is noradrenergic terminal-dependent, Neurosci. Lett., 115 (1990) 253-258.
8. Cohen, S.A. and Strydom, D.J., Amino acid analysis utilizing phenylisothiocyanate derivatives, Anat. Biochem., 174 (1988) 1-16.
9. De Biasi, S. and Rustioni, A., Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord, Proc. Natl. Acad. Sci. USA, 85 (1988) 7820-7824.
10. Edvinsson, L., Adamsson, M. and Jansen, I., Neuropeptide Y antagonistic properties of D-myo-inositol 1,2,6-triphophate in guinea pig basilar arteries, Neuropeptides, 17 (1990) 99-105.
11. Feth, F., Erdbrügger, W., Rascher, W. and M.C. Michel, M.C., Is PP56 (D-myo-inositol 1,2,6-trisphosphate) an antagonist at neuropeptide Y receptors?, Life Sci., 52 (1990) 1835-1844.
12. Goldschmidt, B., Preparation of D-myo-inositol 1,2,6-trisphosphate, Carbohyd. Res., 208 (1990) 105-110.
13. Haley, J.E., Sullivan, A.F. and Dickenson, A.M., Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat, Brain Res., 518 (1990) 218-226.
14. Heilig, M., Edvinsson, L. and Wahlestedt, C., Effects of intracerebroventricular D-myo-inositol-1,2,6-triphophate (PP56), a proposed neuropeptide Y (NPY) antagonist, on locomotor activity, food intake, central effects of NPY and NPY-receptor binding, Eur. J. Pharmacol., 209 (1991) 27-32.
15. Lehmann, A., Hagberg, H. and Hamberger, A., A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation, Neurosci. Lett., 52 (1984) 341-346.
16. Lund, T. and Reed, R., α-Trinositol inhibits edema generation and albumin extravasation in thermally injured skin, J. Trauma, 36 (1994) 761-765.
17. Malmberg, A.B., Fallgren, B. and Hedner, T., Antinociceptive effect of α-trinositol, a novel D-myo-Inositol Phosphate derivative, in the formalin test in rats, Eur. J. Pharmacol., 294 (1995) 609-615.
18. 2 and capsaicin on behavior and cerebrospinal fluid amino acid concentrations of unanesthetized rats: a microdialysis study, J. Neurochem., 65 (1995) 2185-2193.
19. Malmberg, A.B., Yaksh, T.L. and Calcutt, N.A., Anti-nociceptive effects of the GM1 ganglioside derivative AGF 44 on the formalin test in normal and streptozotocin-diabetic rats, Neurosci. Lett., 161 (1993) 45-48.
20. Malmberg, A.B. and Yaksh, T.L., Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N and P type channels inhibit formalin-induced nociception, J. Neurosci., 14 (1994) 4882-4890.
21. 2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats, J. Neurosci., 15 (1995) 2768-2776.
22. Marriott, D.R., Wilkin, G.P. and Wood, J.N., Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism, J. Neurochem., 56 (1991) 259-65.
23. Marsala, M., Malmberg, A.B. and Yaksh, T.L., The spinal loop dialysis catheter: characterization of use in the unanesthetized rat, J. Neurosci. Methods, 62 (1995) 43-53.
24. Merighi, A., Polac, J.M. and Theodosis, D.T., Ultrastructural visualization of glutamate and aspartate immunoreactivities in the rat dorsal horn, with special reference to the co-localization of glutamate, substance P and calcitonin gene-related peptide, Neuroscience, 40 (1991) 67-80.
25. Mikoshiba, K., Inositol 1,4,5-trisphosphate receptor, Trends Pharmacol. Sci., 14 (1993) 86-89.
26. Nakazawa, H., Gustafsson, T.O., Traber, L., Herndon, D. and Traber, D., α-Trinositol decreases lung edema formation after smoke inhalation in an ovine model, J. Appl. Physiol., 76 (1994) 278-282.
27. 2 increases calcium conductance and stimulates release of substance P in Avian sensory neurons, J. Neurosci., 12 (1992) 1917-1927.
28. Paleckova, V., Palecek, J., McAdoo, D.J. and Willis, W.D., The non-NMDA antagonist CNQX prevents release of amino acids into the rat spinal cord dorsal horn evoked by sciatic nerve stimulation, Neurosci. Lett., 148 (1992) 19-22.
29. Pernow, J., Modin, A. and Lundberg, J.M., No effect of D-myo-inositol 1,2,6-trisphosphate on vasoconstriction evoked by neuropeptide Y and non-adrenergic sympathetic nerve stimulation, Eur. J. Pharmacol., 222 (1992) 171-174.
30. Potter, E.K., Edvinsson, L. and T. Gustafsson, T., Antagonism of pre- and postjunctional responses to neuropeptide Y and sympathetic stimulation by D-myo-inositol-1,2,6-triphophate in the anaesthetised dog, Eur. J. Pharmacol., 221 (1992) 307-314.
31. Puig, S. and Sorkin, L.S., Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity, Pain, 64 (1996) 345-355.
32. Skilling, S.R., Smullin, D.H., Beitz, A.J. and Larson, A.A., Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation, J. Neurochem., 51 (1988) 127-132.
33. Smullin, D.H., Skilling, S.R. and Larson, A.A., Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord, Pain, 42 (1990) 93-101.
34. 4-binding sites. Br. J. Pharmacol., 117 (1996) 919-925.
35. Sun, X.Y., Edvinsson, L. and Hedner, T., Effects of D-myo-inositol-1,2,6-triphophate on neuropeptide Y-induced potentiation of various vasoconstrictor agents in the rat, J. Pharmacol. Exp. Ther., 261 (1992) 1147-1152.
36. 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture, J. Neurosci., 14 (1994) 4987-4997.
37. Vasko, M.R., Zirkelbach, S.L. and Waite, K.J., Prostaglandins stimulate the release of substance P from rat spinal cord slices. In I. Jurna and T.L. Yaksh (Eds.), Progress in Pharmacology and Clinical Pharmacology, Vol. 10, Gustav Fischers Verlag, Stuttgart, New York., 1993, pp. 69-89.
38. Wahlestedt, C., Reis, D.J., Yoo, H., Adamsson, M., Andersson, D. and Edvinsson, L., A novel inositol phophate selectively inhibitos vasoconstriction evoked by the sympathetic cotransmitters, neuropeptide Y (NPY) and adenosine triphosphate (ATP), Neurosci. Lett., 143 (1992) 123-126.
39. 3H]a-Trinositol (1D-myo-Inositol 1,2,6-trisphophate) binding sites in human and mammalian tissues, J. Pharmacol. Exp. Ther., 273 (1995) 461-469.
40. Westlund, K.N., McNeill, D.L. and Coggeshall, R.E., Glutamate immunoreactivity in rat dorsal root axons, Neurosci. Lett., 96 (1989) 13-17.
41. Westlund, K.N., McNeill, D.L., Patterson, J.T. and Coggeshall, R.E., Aspartate immunoreactive axons in normal rat L4 dorsal roots, Brain Res., 489 (1989) 247-351.
42. Yamamoto, T. and Yaksh, T.L., Comparison of the antinociceptive effects of pre and post treatment with intrathecal morphine and MK801, an NMDA antagonist on the formalin test in the rat, Anesthesiology, 77 (1992) 757-763.
43. Yoo, H., Fallgren, B., Lindahl, A. and C. Wahlestedt, C., 1994, Characterization of specific binding sites for a-trinositol (D-myo-inositol 1,2,6-trisphosphate) in rat tissues, Eur. J. Pharmacol., 268 (1994) 55-63.