Abnormal expression of the proliferating cell nuclear antigen (PCNA) in the spinal cord of the hypomyelinated Jimpy mutant mice

Brain Research

Volumn 747, Issue 1, 1997, Pages 130-139

  Vela Hernández, José M ^a   Dalmau, Ishar ^a   González, Berta ^a   Castellano, Bernardo ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

astroglia; cell cycle; imag e analysis; microglia; neuroglia; oligodendroglia; proliferation

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MYELIN BASIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DEMYELINATION; IMMUNOCYTOCHEMISTRY; MALE; MICROGLIA; MOUSE; MUTANT; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SPINAL CORD;

ANIMALS; ASTROCYTES; CELL DIVISION; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LECTINS; MICE; MICE, INBRED C57BL; MICE, JIMPY; MICROGLIA; MYELIN BASIC PROTEINS; MYELIN SHEATH; NEUROGLIA; OLIGODENDROGLIA; PLANT LECTINS; PROLIFERATING CELL NUCLEAR ANTIGEN; SPINAL CORD;

EID: 0031041489     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01267-X     Document Type: Article

References (64)

1. Acarín, L., Vela, J.M., González, B. and Castellano, B., Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding, J. Histochem. Cytochem., 42 (1994) 1033-1041.
2. 2 DNA content, Cell Tissue Kinet., 16 (1983) 237-243.
3. 1 genes, Cancer Res., 51 (1991) 1741-1743.
4. Bartlett, W.P., Knapp, P.E. and Skoff, R.P., Glial conditioned medium enables jimpy oligodendrocytes to express properties of normal oligodendrocytes: production of myelin antigens and membranes, Glia, 1 (1988) 253-259.
5. Benveniste, E.N., Astrocyte-microglia interactions. In: S. Murphy (Ed.), Astrocytes: Pharmacology and Function, Vol. 15, Academic Press, San Diego, CA, 1993, pp. 355-382.
6. Best, T.T., Skoff, R.P. and Bartlett, W.P., Astroglial plasticity in hemizygous and heterozygous jimpy mice, Int. J. Dev. Neurosci., 6 (1988) 39-57.
7. Bignami, A., Eng, L.F., Dahl, D. and Uyeda, T., Localization of glial fibrillary acidic protein in astrocytes by immunofluorescence, Brain Res., 43 (1972) 429-435.
8. Bravo, R. and Macdonald-Bravo, H., Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites, J. Cell Biol., 105 (1987) 1549-1554.
9. Bravo, R., Frank, R., Blundell, P.A. and Macdonald-Bravo, H., Cyclin/PCNA is the auxiliary protein of DNA polymerase-∂, Nature, 326 (1987) 515-517.
10. Camplejohn, R.S., The measurement of intracellular antigens and DNA by multiparametric flow cytometry, J. Microsc., 176 (1994) 1-7.
11. Czader, M., Porwit, A., Tani, E., Ost, A., Mazur, J. and Auer, G., DNA image cytometry and the expression of proliferative markers (proliferating cell nuclear antigen and Ki67) in non-Hodgkin's lymphomas, Mod. Pathol., 8 (1995) 51-58.
12. Dautigny, A., Mattei, M.-G., Morello, D., Alliel, P.M., Pham-Dinh, D., Amar, L., Arnaud, D., Simon, D., Mattei, J.-F., Guenet, J.-L., Jollès, P. and Avner, P., The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice, Nature, 321 (1986) 867-869.
13. Del Rio-Hortega, P., Microglia. In: W. Penfield (Ed.), Cytology and Cellular Pathology of the Nervous System, Vol. 2, Hoeber, New York, 1932, pp. 481-534.
14. 2 phase, Cell Tissue Kinet., 17 (1984) 453-461.
15. Dupouey, P., Lucas, C.V., Gomes, D. and Jacque, C., Immunohistochemical localization of the myelin basic protein and of the glial fibrillary acidic protein: comparative study in normal, quaking and jimpy mice, J. Neurosci. Res., 5 (1980) 387-398.
16. Dutly, F. and Schwab, M.E., Neurons and astrocytes influence the development of purified O-2A progenitor cells, Glia, 4 (1991) 559-571.
17. Farkas-Bargeton, E., Robain, O. and Mandel, P., Abnormal glial maturation in the white matter in jimpy mice. An optical study, Acta Neuropathol. (Berl.), 21 (1972) 272-281.
18. Frei, K., Bodmer, S., Schwerdel, C. and Fontana, A., Astrocyte-derived interleukin 3 as a growth factor for microglial cells and peritoneal macrophages, J. Immunol., 137 (1986) 3521-3527.
19. Frei, K., Siepl, C., Groscurth, P., Bodmer, S., Schwerdel, C. and Fontana, A., Antigen presentation and tumor cytotoxicity by interferon-gamma treated microglial cells, Eur. J. Immunol., 17 (1987) 1271-1278.
20. 0 arrest of human fibroblasts, Exp. Cell Res., 220 (1995) 220-225.
21. Ghandour, M.S. and Skoff, R.P., Expression of galactocerebroside in developing normal and jimpy oligodendrocytes in situ, J. Neurocytol., 17 (1988) 485-498.
22. Giulian, D. and Ingeman, J., Colony stimulating factors as activators of ameboid microglia, J. Neurosci., 8 (1988) 4701-4712.
23. Giulian, D., Johnson, B., Krebs, J.F., George, J.K. and Tapscott, M., Microglial mitogens are produced in the developing and injured mammalian brain, J. Cell Biol., 112 (1991) 323-333.
24. Giulian, D. and Corpuz, M., Microglial secretion products and their impact on the nervous system. In: F.J. Seil (Ed.), Advances in Neurology, Vol. 59, Raven Press, New York, 1993, pp. 315-320.
25. Giulian, D., The consequences of inflammation after injury to the central nervous system. In: S.K. Salzman and A.I. Faden (Eds.), The Neurobiology of Central Nervous System Trauma, Oxford University Press, New York, 1994, pp. 155-164.
26. Graeber, M.B., Tetzlaff, W., Streit, W.J. and Kreutzberg, G.W., Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy, Neurosci. Lett., 85 (1988) 317-321.
27. Hamilton, S.P. and Rome, L.H., Stimulation of in vitro myelin synthesis by microglia, Glia, 11 (1994) 326-335.
28. Hertz, L., Chaban, G. and Hertz, E., Abnormal metabolic response to excess potassium in astrocytes from the Jimpy mouse, a convulsing neurological mutant, Brain Res., 181 (1980) 482-487.
29. Hopkins, S.J. and Rothwell, N.J., Cytokines and the nervous system. I. Expression and recognition, Trends Neurosci., 18 (1995) 83-88.
30. Jaskulski, D., De Riel, J.K., Mercer, W.E., Calbretta, B. and Baserga, R., Inhibition of cellular proliferation by antisense oligonucleotides to PCNA cyclin, Science, 240 (1988) 1544-1546.
31. Keen, P., Osborne, R.H. and Pehrson, U.M.M., Respiration and metabolic compartmentation in brain slices from a glia-deficient mutant, the jimpy mouse, J. Physiol (Lond.), 245 (1976) 22-23.
32. Knapp, P.E., Skoff, R.P. and Redstone, D.W., Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit, J. Neurosci., 6 (1986) 2813-2822.
33. Knapp, P.E. and Skoff, R.P., A defect in the cell cycle of neuroglia in the myelin deficient Jimpy mouse, Dev. Brain Res., 35 (1987) 301-306.
34. Knapp, P.E., Booth, C.S. and Skoff, R.P., The pH of Jimpy glia is increased: intracellular measurements using fluorescent laser cytometry, Int. J. Dev. Neurosci., 11 (1993) 215-226.
35. Knapp, P.E. and Skoff, R.P., Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro, Dev. Neurosci., 15 (1993) 31-36.
36. Li, X. and Bartlett, W.P., Developmental expression of glial fibrillary acidic protein and glutamine synthetase mRNAs in normal and Jimpy mice, Mol. Brain Res., 9 (1991) 313-317.
37. Lohr, F., Wenz, F., Haas, S. and Flentje, M., Comparison of proliferating cell nuclear antigen (PCNA) staining and BrdUrd-labeling index under different proliferative conditions in vitro by flow cytometry, Cell Prolif., 28 (1995) 93-104.
38. McCormick, D. and Hall, P.A., The complexities of proliferating cell nuclear antigen, Histopathology, 21 (1992) 591-594.
39. Mathews, M.B., Bernstein, R.M., Franza, Jr., B.R. and Garrels, J.I., Identity of the proliferating cell nuclear antigen and cyclin, Nature, 309 (1984) 374-376.
40. Merrill, J.E., Effects of interleukin-1 and tumor necrosis factor-α on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro, Dev. Neurosci., 13 (1991) 130-137.
41. Mizuno, T., Sawada, M., Suzumura, A. and Marunouchi, T., Expression of cytokines during glial differentiation, Brain Res., 656 (1994) 141-146.
42. Morris, G.F. and Mathews, M.B., Regulation of proliferating cell nuclear antigen during the cell cycle, J. Biol. Chem., 264 (1989) 13856-13864.
43. Nave, K.-A., Lai, C., Bloom, F.E. and Milner, R.J., Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing, Proc. Natl. Acad. Sci. (USA), 83 (1986) 9264-9268.
44. Nave, K.-A., Bloom, F.E. and Milner, R.J., A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse, J. Neurochem., 49 (1987) 1873-1877.
45. Prelich, G., Tan, C.-K., Kostura, M., Mathews, M.B., So, A.G., Downey, K.M. and Stillman, B., Functional identity of proliferating cell nuclear antigen and a DNA polymerase-∂ auxiliary protein, Nature, 326 (1987) 517-520.
46. Privat, A., Robain, O. and Mandel, P., Aspects ultrastructuraux du corps calleux chez la souris Jimpy, Acta Neuropathol. (Berl.), 21 (1972) 282-295.
47. Privat, A., Valat, J., Lachapelle, F., Baumann, N. and Fulcrand, J., Radioautographic evidence for the protracted proliferation of glial cells in the central nervous system of Jimpy mice, Dev. Brain Res., 2 (1982) 411-416.
48. Roos, G., Landberg, G., Huff, J.P., Houghten, R., Takasaki, Y. and Tan, E.M., Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies, Lab. Invest., 68 (1993) 204-210.
49. Rothwell, N.J. and Hopkins, S.J., Cytokines and the nervous system. II. Actions and mechanisms of action, Trends Neurosci., 18 (1995) 130-136.
50. Sawada, M., Suzumura, A., Yamamoto, H. and Marunouchi, T., Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C, Brain Res., 509 (1990) 119-124.
51. Shivji, M.K.K., Kenny, M.K. and Wood, R.D., Proliferating cell nuclear antigen is required for DNA excision repair, Cell, 69 (1992) 367-374.
52. Skoff, R.P., The fine structure of pulse labeled [3H]thymidine cells in degenerating rat optic nerve, J. Comp. Neurol., 161 (1975) 595-612.
53. Skoff, R.P., Myelin deficit in the jimpy mouse may be due to cellular abormalities in astroglia, Nature, 264 (1976) 560-562.
54. Skoff, R.P., Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpy, Brain Res., 248 (1982) 19-31.
55. Skoff, R.P., Programed cell death in the dismyelinating mutants, Brain Pathol., 5 (1995) 283-288.
56. Sternberger, N.H., Itoyama, Y., Kies, M.W. and Webster, H.deF., Immunocytochemical method to identify basic protein in myelin-forming oligodendrocytes of newborn rat C.N.S., J. Neurocytol., 7 (1978) 251-263.
57. Streit, W.J. and Kreutzberg, G.W., Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin, J. Comp. Neurol., 268 (1988) 248-263.
58. 1/S transition in proliferating cells of the developing cerebral wall, J. Neurocytol., 22 (1993) 1096-1102.
59. Travali, S., Ku, D.-H., Rizzo, M.G., Ottavio, L., Baserga, R. and Calabretta, B., Structure of the human gene for the proliferating cell nuclear antigen, J. Biol. Chem., 264 (1989) 7466-7472.
60. Vela, J.M., Dalmau, I., Acarín, L., González, B. and Castellano, B., Microglial cell reaction in the gray and white matter of the Jimpy spinal cord. An enzyme histochemical study at the light and electron microscope level, Brain Res., 694 (1995) 287-298.
61. Vela, J.M., Dalmau, I., González, B. and Castellano, B., The microglial reaction in spinal cords of Jimpy mice is related to apoptotic oligodendrocytes, Brain Res., 712 (1996) 134-142.
62. Vermeesch, M.K., Knapp, P.E., Skoff, R.P., Studzinski, D.M. and Benjamins, J.A., Death of individual oligodendrocytes in jimpy precedes expression of proteolipid protein, Dev. Neurosci., 12 (1990) 303-315.
63. Wada, T., Shimabukuro, T., Matsuyama, H., Naito, K., Skog, S. and Tribukait, B., Optimal conditions of fixation for immunohistochemical staining of proliferating cell nuclear antigen in tumour cells and its cell cycle related immunohistochemical expression, Cell Prolif., 27 (1994) 541-551.
64. Zölzer, F., Streffer, C. and Pelzer, T., A comparison of different methods to determine cell proliferation by flow cytometry, Cell Prolif., 27 (1994) 685-694.