Acute effects of propylthiouracil on hemodynamics and oxygen content in patients with alcoholic cirrhosis

Journal of Hepatology

Volumn 26, Issue 3, 1997, Pages 628-633

  Sogni, Philippe ^a   Hadengue, Antoine ^a   Moreau, Richard ^a   Moine, Olivier Le ^a   Soupison, Thierry ^a   Oberti, Frédérique ^a   Farinotti, Robert ^b   Lebrec, Didier ^a  

^a Lab d'Hemodynamique Splanchnique   (France)

^b BICHAT HOSPITAL   (France)

Author keywords

cirrhosis; hemodynamics; oxygen content; propylthiouracil

Indexed keywords

PROPYLTHIOURACIL;

ADULT; ALCOHOL LIVER DISEASE; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HEART OUTPUT; HEART RATE; HEMODYNAMICS; HEPATITIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER CIRRHOSIS; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0031041356     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80429-1     Document Type: Article

References (21)

1. Orrego H, Blake JE, Blendis L, Compton C, Israel Y. Longterm treatment of alcoholic liver disease with propylthiouracil. N Eng J Med. 317:1987;1421-1427.
2. Orrego H, Blake JE, Blendis LM, Compton KV, Volpe R, Israel Y. Long-term treatment of alcoholic liver disease with propylthiouracil. Part 2: Influence of drop-out rates and of continued alcohol consumption in a clinical trial. J Hepatol. 20:1994;343-349.
3. Israel Y, Kalant H, Orrego H, Khanna JM, Videla L, Phillips JM. Experimental alcohol-induced hapatic necrosis: supression by propylthiouracil. Proc Natl Acad Sci USA. 72:1975;1137-1141.
4. Britton RS, Koves G, Orego H, Kalant H, Phillips MJ, Khanna JM, Israel Y. Suppression by antithyroid drugs of experimental hepatic necrosis after ethanol treatment. Effect on thyroid gland or on peripheral deiodination. Toxicol Appl Pharmacol. 51:1979;145-155.
5. Orrego H, Carmichael FJ, Phillips MJ, Kalant H, Khanna J, Israel Y. Protection by propylthioracil against carbon tetrachloride-induced damage. Gastroenterology. 71:1976;821-826.
6. Linscheer WG, Raheja KL, Cho C, Smith NJ. Mechanism of the protective effct of propylthiouracil against acetaminophen (Tylnelol) toxicity in the rat. Gastroenterology. 78:1980;100-1007.
7. vitro studies in rats and mice. J Clin Invest. 67:1981;688-695.
8. Raheja KL, Linscheer WG, Cho C, Mahany D. Protective effect of prpylthiouracil independent of its hypothyroid effect on acetaminophen toxicity in the rat. J Pharmacol Exp Ther. 220:1982;427-432.
9. Cook D, Tolman KG, Gray P. The influence of thyroid hormones and propylthiouracil on salicylate hepatototoxicity in monolayer cell cultures. Biochem Pharmacol. 32:1983;1454-1456.
10. Cooper DS, Carter EA, Kieffer D, Wand JR. Effect of propylthiouracil on D-galactosamine hepatotoxicity in the rat. Evidence for a non-thyroidal effect. Biochem Pharmacol. 33:1984;3391-3397.
11. Yuki T, Israel Y, Thurnman RG. The swift increase in alcohol metabolism. Inhibition by propylthiouracil. Biochem Pharmacol. 31:1982;2403-2407.
12. Carmichael FJ, Orrego H, Saldivia V, Israel Y. Effect of propylthmioracil on the ethanol-induced increase in liver oxygen consumption in awake rats. Hepatology. 18:1993;415-421.
13. French SW, Benson NC, Sun PS. Centrilobular liver necrosis induced by hypoxia in chronic ethanol-fed rats. Hepatology. 1:1984;912-917.
14. Lieber CS, Baraona E, Hernandez-Munoz R, Kubota S, Sato N, Kawano S, Matsumura T, Inatomi N. Impaired oxygen utilization. A new mechanisms for the hepatoxicity of ethanol in sub-human primates. J Clin Invest. 82:1989;1682-1690.
15. Sato N, Kamada T, Kawano S, Hayashi N, Kishida Y, Meren H, Yoshihara H, Abe H. Effect of acute and chronic ethanol consumption on hepatic tissue oxygen tension in rats. Pharmacol Biochem Behav. 1:1983;443-447.
16. Tsukamoto H, Xi XP. Incomplete compensation of enhanced hepatic oxygen consuption in rats with alcoholic centribolular liver necrosis. Hepatology. 9:1989;302-306.
17. Kawasaki T, Carmichael FJ, Giles G, Saldivia V, Israel Y, Orrego H. Effects of propylthiouracil and methimazole on splanchnic hemodynamic in awake and unrestrained rats. Hepatology. 10:1989;273-278.
18. Rojter S, Tessler J, Alvarez D, Persico R, Lopez P, Bandi JC, Podesta A, Terg R, Gutman R, Mastai R. Vasodilaroty effects of propylthiouracil in patients with alcoholic cirrhosis. J Hepatol. 22:1995;184-188.
19. Giles HG, Miller R, Sellers EM. High-performance liquid chromatographic determination of plasma propylthiouracil. J Pharm Sci. 68:1979;1459-1460.
20. Calès P, Braillon A, Jiron MI, Lebrec D. Superior portosystemic collateral circulation estimated by azygos blood flow in patients with cirrhosis. Lack of correlation with oesophageal varices and gastrointestinal bleeding, effect of propranolol. J Hepatol. 1:1984;37-46.
21. Hadengue A, Moreau R, Lee SS, Gaudin C, Rueff B, Lebrec D. Liver hypermetabolism during alcohol withdrawal in humans. Role of sympathic overactivity. Gastroenterology. 94:1988;1047-1052.