The role of ATF in regulating the human cytomegalovirus DNA polymerase (UL54) promoter during viral infection

Journal of Virology

Volumn 71, Issue 3, 1997, Pages 2120-2126

  Kerry, Julie A ^a   Priddy, Morris A ^a   Staley, Terri L ^a   Jones, Thomas R ^b   Stenberg, Richard M ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; PHOSPHONOACETIC ACID; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; CYTOMEGALOVIRUS; DNA BINDING; DNA PROTEIN COMPLEX; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; OPEN READING FRAME; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; TRANSACTIVATION; TRANSCRIPTION INITIATION; VIRUS INFECTION;

EID: 0031041309     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.3.2120-2126.1997     Document Type: Article

References (63)

1. Adam, B.-L., T. Y. Jervey, C. P. Kohler, G. L. Wright, Jr., J. A. Nelson, and R. M. Stenberg. 1995. The human cytomegalovirus UL98 gene transcription unit overlaps with the pp28 true late gene (UL99) and encodes a 58-kilo-dalton early protein. J. Virol. 69:5304-5310.
2. Agulnick, A. D., J. R. Thompson, and R. P. Ricciardi. 1994. An ATF/CREB site is the major regulatory element in the human herpesvirus 6 DNA polymerase promoter. J. Virol. 68:2970-2977.
3. Boldogh, I., S. AbuBakar, M. P. Fons, C. Z. Deng, and T. Albrecht. 1991. Activation of cellular oncogenes by clinical isolates and laboratory strains of human cytomegalovirus. J. Med. Virol. 34:241-247.
4. Boldogh, I., S. AbuBakar, and T. Albrecht. 1990. Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. Science 247:561-564.
5. Brauweiler, A., P. Garl, A. A. Franklin, H. A. Giebler, and J. K. Nyborg. 1995. A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation. J. Biol. Chem. 270:12814-12822.
6. Britt, W. J., and C. A. Alford. 1996. Cytomegalovirus, p. 2493-2523. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Virology, 3rd ed. Raven Press, New York, N.Y.
7. Chang, C.-P., C. L. Malone, and M. F. Stinski. 1989. A human cytomegalovirus early gene has three inducible promoters that are regulated differentially at various times after infection. J. Virol. 63:281-290.
8. Cherrington, J. M., and E. S. Mocarski. 1989. Human cytomegalovirus ie1 transactivates the α promoter-enhancer via an 18-base-pair repeat element. J. Virol. 63:1435-1440.
9. Colberg-Poley, A. M., L. D. Santomenna, P. P. Harlow, P. A. Benfield, and D. J. Tenney. 1992. Human cytomegalovirus US3 and UL36-38 immediate-early proteins regulate gene expression. J. Virol. 66:95-105.
10. Depto, A. S., and R. M. Stenberg. 1992. Functional analysis of the true late human cytomegalovirus pp28 upstream promoter: cis-acting elements and viral trans-acting proteins necessary for promoter activation. J. Virol. 66: 3241-3246.
11. Desdouets, C., G. Matesic, C. A. Molina, N. S. Foulkes, P. Sassone-Corsi, C. Brechot, and J. Sobczak-Thepot. 1995. Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM. Mol. Cell. Biol. 15:3301-3309.
12. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
13. Einhorn, L., and A. Ost. 1984. Cytomegalovirus infection of human blood cells. J. Infect. Dis. 149:207-214.
14. Fickenscher, H., T. Stamminger., R. Ruger, and B. Fleckenstein. 1989. The role of a repetitive palindromic sequence element in the human cytomegalovirus major immediate early enhancer. J. Gen. Virol. 70:107-123.
15. Hai, T., and T. Curran. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720-3724.
16. Henninghausen, L., and B. Fleckenstein. 1986. Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene. EMBO J. 5:1367-1371.
17. Huang, L., C. L. Malone, and M. F. Stinski. 1994. A human cytomegalovirus early promoter with upstream negative and positive cis-acting elements: IE2 negates the effect of the negative element, and NF-Y binds to the positive element. J. Virol. 68:2108-2117.
18. Hunninhake, G. W., M. M. Monick, B. Liu, and M. F. Stinski. 1989. The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-responsive elements. J. Virol. 63:3026-3033.
19. Hurst, H. C., N. F. Totty, and N. C. Jones. 1991. Identification and functional characterization of the cellular activating transcription factor 43 (ATF-43) protein. Nucleic Acids Res. 19:4601-4609.
20. Ibanez, C. E., R. Schrier, P. Ghazal, C. Wiley, and J. A. Nelson. 1991. Human cytomegalovirus productively infects primary differentiated macrophages. J. Virol. 65:6581-6588.
21. Iskenderian, A. C., L. Huang, A. Reilly, R. M. Stenberg, and D. G. Anders. 1995. Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes. J. Virol. 70:383-392.
22. Jones, T. R., and V. P. Muzithras. 1992. A cluster of dispensable genes within the human cytomegalovirus genome short component: IRS1, US1 through US5, and the US6 family. J. Virol. 66:2541-2546.
23. Jones, T. R., V. P. Muzithras, and Y. Gluzman. 1991. Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential. J. Virol. 65:5860-5872.
24. Kerry, J. A. Unpublished data.
25. Kerry, J. A., M. A. Priddy, and R. M. Stenberg. 1994. Identification of sequence elements in the human cytomegalovirus DNA polymerase gene promoter required for activation by viral gene products. J. Virol. 68:4167-4176.
26. Kerry, J. A., M. A. Priddy, T. Y. Jervey, C. P. Kohler, T. L. Staley, C. D. Vanson, T. R. Jones, A. C. Iskenderian, D. G. Anders, and R. M. Stenberg. 1996. Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection. J. Virol. 70:373-382.
27. Kerry, J. A., M. A. Priddy, C. P. Kohler, T. L. Staley, D. Weber, T. R. Jones, and R. M. Stenberg. 1997. Translational regulation of the human cytomegalovirus pp28 (UL99) late gene. J. Virol. 71:981-987.
28. Klucher, K. M., and D. H. Spector. 1990. The human cytomegalovirus 2.7-kilobase RNA promoter contains a functional binding site for the adenovirus major late transcription factor. J. Virol. 64:4189-4198.
29. Klucher, K. M., D. K. Rabert, and D. H. Spector. 1989. Sequences in the human cytomegalovirus 2.7-kilobase RNA promoter which mediate its regulation as an early gene. J. Virol. 63:5334-5343.
30. Kohler, C. P., J. A. Kerry, M. Carter, V. P. Muzithras, T. R. Jones, and R. M. Stenberg. 1994. Use of recombinant virus to assess human cytomegalovirus early and late promoters in the context of the viral genome. J. Virol. 68: 6589-6597.
31. Kvietikova, I., R. H. Wenger, H. H. Marti, and M. Gassmann. 1995. The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res. 23: 4542-4550.
32. Labrie, C., B. H. Lee, and M. B. Mathews. 1995. Transcription factors RFX1/EF-C and ATF-1 associate with the adenovirus E1A-responsive element of the human proliferating cell nuclear antigen promoter. Nucleic Acids Res. 23:3732-3741.
33. Lang, D., S. Gebert, H. Alt, and T. Stamminger. 1995. Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB. J. Virol. 69:6030-6037.
34. Lathey, J. L., and S. A. Spector. 1991. Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages. J. Virol. 65:6371-6375.
35. Lee, K. A., and N. Masson. 1993. Transcriptional regulation by CREB and its relatives. Biochim. Biophys. Acta 1174:221-233.
36. Liu, B., and M. F. Stinski. 1992. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J. Virol. 66:4434-4444.
37. Liu, F., and M. R. Green. 1990. A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein. Cell 61:1217-1224.
38. Masson, N., H. C. Hurst, and K. A. W. Lee. 1993. Identification of proteins that interact with CREB during differentiation of F9 embryonal carcinoma cells. Nucleic Acids Res. 21:1163-1169.
39. Masson, N., J. John, and K. A. W. Lee. 1993. In vitro phosphorylation studies of a conserved region of the transcription factor ATF-1. Nucleic Acids Res. 21:4166-4173.
40. Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371-378.
41. Nakamura, T., S. Okuyama, S. Okamoto, T. Nakajima, S. Sekiya, and K. Oda. 1995. Down-regulation of the cyclin A promoter in differentiating human embryonal carcinoma cells is mediated by depletion of ATF-1 and ATF-2 in the complex at the ATF/CRE site. Exp. Cell Res. 216:422-430.
42. Pabo, C. O., and R. T. Sauer. 1992. Transcription factors: structural families and principles of DNA recognition. Annu. Rev. Biochem. 61:1053-1095.
43. Rehfuss, R. P., K. M. Walton, M. M. Loriaux, and R. H. Goodman. 1991. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J. Biol. Chem. 266:18431-18434.
44. Rice, G. P. A., R. D. Schrier, and M. B. A. Oldstone. 1984. Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products. Proc. Natl. Acad. Sci. USA 81:6134-6138.
45. Sambucetti, L. C., J. M. Cherrington, G. W. Wilkinson, and E. S. Mocarski. 1989. NF-κB activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation. EMBO J. 8:4251-4258.
46. Schrier, R. D., J. A. Nelson, and M. B. A. Oldstone. 1985. Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science 230:1048-1051.
47. Scott, D. M., B. C. Rodgers, C. Freeke, J. Buiter, and J. G. P. Sissons. 1989. Human cytomegalovirus and monocytes: limited infection and negligible immunosuppression in normal mononuclear cells infected in vitro with mycoplasma-free virus strains. J. Gen. Virol: 70:685-694.
48. Sinclair, J. H., J. Baille, L. A. Bryant, J. A. Taylor-Weideman, and J. G. P. Sissons. 1992. Repression of human cytomegalovirus major immediate early gene expression in a monocylic cell line. J. Gen. Virol. 73:433-435.
49. Sommer, M. H., A. L. Scully, and D. H. Spector. 1994. Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J. Virol. 68:6223-6231.
50. Spector, D. H., K. M. Klucher, D. K. Rabert, and D. A. Wright. 1990. Human cytomegalovirus early gene expression. Curr. Top. Microbiol. Immunol. 154: 21-45.
51. Stamminger, and B. Fleckenstein. 1990. Immediate-early transcription regulation of human cytomegalovirus. Curr. Top. Microbiol. Immunol. 154:3-19.
52. Staprans, S. I., and D. H. Spector. 1986, 2.2-Kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169. J. Virol. 57:591-602.
53. Staprans, S. I., D. K. Rabert, and D. H. Spector. 1988. Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene. J. Virol. 62:3463-3473.
54. Stein, J., H. D. Volk, C. Liebenthal, D. H. Krug, and S. Prosch. 1993. Tumour necrosis factor α stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells. J. Gen. Virol. 74:2333-2338.
55. Stenberg, R. M. 1993. Immediate-early genes of human cytomegalovirus: organization and function, p. 330-359. In E.-S. Huang (ed.), Molecular aspects of human cytomegalovirus diseases. Springer-Verlag, Heidelberg, Germany.
56. Stenberg, R. M., A. S. Depto, J. Fortney, and J. A. Nelson. 1989. Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region. J. Virol. 63:2699-2708.
57. Stenberg, R. M., and J. A. Kerry. 1995. Cytomegalovirus genes: their structure and function. Scand. J. Infect. Dis. Suppl. 99:3-6.
58. Taylor-Wiedeman, J., J. G. Sissons, L. K. Borysiewicz, and J. H. Sinclair. 1991. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J. Gen. Virol. 72:2059-2064.
59. Wade, E. J., K. M. Klucher, and D. H. Spector. 1992. An AP-1 binding site is the predominant cis-acting regulatory element in the 1.2-kilobase early RNA promoter of human cytomegalovirus. J. Virol. 66:2407-2417.
60. Wagner, S., and M. W. Green. 1993. HTLV-1 Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science 262:395-399.
61. Weinshenker, B. G., S. Wilton, and G. P. A. Rice. 1988. Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in a monocyte cell line. J. Immunol. 140:1625-1631.
62. Wing, B. A., and E.-S. Huang. 1995. Analysis and mapping of a family of 3′-coterminal transcripts containing coding sequences for human cytomeg-alovirus open reading frames UL93 through UL99. J. Virol. 69:1521-1531.
63. Yoshizumi, M., C.-M. Hseih, F. Zhou, J.-C. Tsai, C. Patterson, M. A. Perrella, and M.-E. Lee. 1995. The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Mol. Cell. Biol. 15:3266-3272.