Can in vitro measurements predict the lung deposition of dry-powder inhalers?

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 10, Issue SUPPL. 1, 1997, Pages

  Olsson, Bo ^a  

^a Pharmaceutical and Analyt R and D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CROMOGLYCATE DISODIUM; CYCLOHALER; FLUTICASONE; SALBUTAMOL; TERBUTALINE; UNCLASSIFIED DRUG;

ADULT; ASTHMA; CHILD; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MEASUREMENT; METERED DOSE INHALER; PARTICLE SIZE; POWDER INHALER; RESPIRATORY TRACT DISEASE; ROTAHALER;

EID: 0031041192     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. BERG E. In vitro properties of pressurised metered dose inhalers with and without spacer devices. J Aerosol Med 1995; 8(Suppl 3):S3-11.
2. BORGSTRÖM L, BONDESSON E, MÓREN F, TROFAST E, NEWMAN SP. Lung deposition of budesonide inhaled via Turbuhaler: a comparison with terbutaline sulphate in normal subjects. Eur Respir J 1994;7:69-73.
3. OLSSON B. Aerosol particle generation from dry powder inhalers - can they equal pressurized metered dose inhalers? J Aerosol Med 1995;8(Suppl 3):S13-9.
4. OLSSON B, ASKING L. Critical aspects of the function of inspiratory flow driven inhalers. J Aerosol Med 1994;7(Suppl 1):S-43-47.
5. OLSSON B, ASKING L, BORGSTRÖM L, BONDESSON E. Effect of inlet throat on the correlation between measured fine particle dose and lung deposition. In: Dalby RN, Byron PR, Farr SY (eds). Respiratory Drug Delivery V; 1996, Phoenix AZ. Buffalo Grove, IL, USA: Interpharm Press Inc, 1996:273-81.
6. QUESTIONS FOR THE PADAC (PULMONARY-ALLERGY DRUGS ADVISORY COMMITTEE) MEETING, September 25, 1995, Food and Drugs Administration, Freedom of Information Staff, Rodeville, MD, USA.
7. RICHARDS R, DICKSON CR, RENWICK AG, LEWIS RA, HOLGATE ST. Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique. J Pharmacol Exp Ther 1987;241:1028-32.
8. THORSSON L, EDSBÄCKER S, CONRADSON TB. Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered dose inhaler (pMDI). Eur Respir J 1994;7:1839-44.