Gastric motility and mucosal ulcerogenic responses induced by prokinetic drugs in rats under prostaglandin-deficient conditions

Digestive Diseases and Sciences

Volumn 42, Issue 2, 1997, Pages 251-258

  Takeuchi, Koji ^a   Kato, Shinichi ^a   Hirata, Takuya ^a   Nishiwaki, Hidekazu ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

gastric lesion; gastric motility; prokinetic drug; prostaglandin deficiency; rat

Indexed keywords

ATROPINE; CISAPRIDE; INDOMETACIN; METOCLOPRAMIDE; ONDANSETRON; PROKINETIC AGENT; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BLEEDING; ENZYME ACTIVITY; GASTROINTESTINAL MOTILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH EMPTYING; STOMACH LESION; STOMACH MUCOSA; STOMACH ULCER; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CISAPRIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC ACID; GASTRIC EMPTYING; GASTRIC MUCOSA; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; INDOMETHACIN; MALE; METOCLOPRAMIDE; ONDANSETRON; PIPERIDINES; PROSTAGLANDIN ANTAGONISTS; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH ULCER;

EID: 0031040989     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018889129410     Document Type: Article

References (23)

1. Robert A: Prostaglandins and the gastrointestinal tract. In Physiology of the Gastrointestinal Tract. LR Johnson, J Cristensen, MI Grossman, ED Jacobson, SG Shuktz (eds). New York, Raven Press, 1981, pp 1407-1434
2. Takuechi K, Ueki S, Okabe S: Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 31:1114-1121, 1986
3. Whittle BJR: Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 80:94-98, 1981
4. Wallace JL, Keeman CM, Granger DN: Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 259:G462-G467, 1990
5. Takeuchi K, Ueshima K, Hironaka Y, Fujioka Y, Matsumoto J, Okabe S: Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Digestion 49:175-184, 1991
6. Okada M, Niida H, Takeuchi K, Okabe S: Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats. Dig Dis Sci 34:694-702, 1989
7. Takeuchi K, Takehara K, Kato S: Analyses of pathogenic elements involved in gastric lesions induced by indomethacin in rats. Inflammopharmacology 1996 (in press).
8. Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS: Domperidon. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs 24:360-400, 1982
9. Briejer MR, Akkermans LMA, Schuurkes JAJ: Gastrointestinal prokinetic bezamides: The pharmacology underlying stimulation of motility. Pharmacol Rev 47:631-651, 1995
10. Buchheit KH, Buhl T: 5-HT receptor subtypes involved in the stimulatory effect of 5-HT on the peristaltic reflex in vitro. J Gastrointest Motil 5:49-55, 1993
11. Brown NJ, Horton A, Rumsey RDE, Read NW: Granisetron and ondansetron: Effects on the ileal brake mechanism in the rat. J Pharm Pharmacol 45:521-524, 1993
12. 2 in the rat gastric mucosa; establishment of assay procedure and effects of nonsteroidal anti-inflammatory compounds. Jpn J Gastroenterol 77:8-15, 1980
13. Orcyk GP, Berhrnam HR: Ovulation blockade by aspirin or indomethacin; in vivo evidence for a role of prostaglandins in gonadotropin secretion. Prostaglandins 1:3-20, 1972
14. Mersereau WA, Hinchey EJ: Role of gastric mucosal folds in formation of focal ulcers in the rat. Surgery 91:150-155, 1982
15. Ueki S, Takeuchi K, Okabe S: Gastric motility is an important factor in pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Dig Dis Sci 33:209-216, 1988
16. Oomura Y, Ooyama O, Sugimoto M, Nakamura T, Yamada Y: Glucose inhibition of the rat lateral hypothalamus. Nature 247:284-286, 1974
17. Mersereau WA, Hinchey EJ: Relative roles of acid and mucosal compression in ulcerogenesis in indomethacin-insulin-treated rat. Dig Dis Sci 33:1454-1458, 1988
18. Garrick T, Buack S, Bass P: Gastric motility is a major factor in cold-restraint-induced lesion formation in rats. Am J Physiol 250:G191-G199, 1986
19. Yamaguchi T: Relationship between gastric mucosal hemodynamics and gastric motility. Jpn J Gastroenterol 25:299-305, 1989
20. Wallace JL, Granger DN: Pathogenesis of NSAID gastropathy; are neutrophils the culprits? Trend Pharmacol Sci 13:129-131, 1992
21. Asaka H, Kuhes P, Wallace JL, Granger DN: Indomethacin-induced leukocyte adhesion in mesenteric venules; role of lipoxygenase products. Am J Physiol 262:G903-G908, 1992
22. Takeuchi K, Takehara K, Ohuchi T: Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats. Digestion 57:201-209, 1996
23. 4 receptors. Eur J Pharmacol 205:203-208, 1991