Mucosal unresponsiveness to aflatoxin B1 is not broken by cholera toxin

Immunology and Cell Biology

Volumn 75, Issue 1, 1997, Pages 47-53

  Oliver, Alfred R ^a   Silbart, Lawrence K ^a   Keren, David F ^b,c   Van Kruiningen, Herbert J ^a   Miller, Bradford F ^b   Rearick, Christina ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Warde Medical Laboratory   (United States)

Author keywords

aflatoxin B1; cholera toxin; mucosa; secretory IgA; tolerance

Indexed keywords

AFLATOXIN B1; CHOLERA TOXIN; SECRETORY IMMUNOGLOBULIN; THYROGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; INTESTINE MUCOSA; LYMPH NODE; NONHUMAN; PEYER PATCH; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SUIDAE;

EID: 0031040916     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1997.8     Document Type: Article

References (28)

1. Moolten FL, Capparell NJ, Boger E, Mahathalang P. Induction of antibodies against carcinogenic polycyclic aromatic hydrocarbons. Nature 1978; 272: 614-16.
2. Moolten F, Capparell N, Boger E. Reduction of respiratory tract binding of benzo(a)pyrene in mice by immunization. J. Natl Cancer Inst. 1978; 61: 1347-9.
3. Silbart LK, Nordblom G, Keren DF, Wise Jr DS, Lincoln PM, Townsend LB. A rapid and sensitive screening method for the detection of anti-2- acetylaminofluorene immunoglobulins. J. Immunol. Methods 1988; 109: 103-12.
4. Silbart LK, Keren DF. Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity. Science 1989; 243: 1462-4.
5. Silbart LK, Keren DF, McDonald RA, Lincoln PM, Goslinoski L, Smart JB. Characterization of the mucosal immune response to 2-acetylaminofluorene-protein conjugates. Reg. Immunol. 1992; 4: 245-54.
6. Elson CO, Ealding W. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J. Immunol. 1984; 132: 2736-41.
7. Elson CO, Ealding W. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 1984; 133: 2892-7.
8. Lycke N, Holmgren J. Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 1986; 59: 301-8.
9. Cebra JJ, Fuhrman JA, Lebman DA, London SD. Effective gut mucosal stimulation of IgA-committed B cells by antigen. In: F Brown, RM Chanock, RA Lerner, (eds.) Vaccines 86. New York: Cold Spring Harbor Laboratory. 1986; 129-33.
10. Lycke N, Bromander AK, Ekman L, Karlsson U, Holmgren J. Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo. J. Immunol. 1989; 142: 20-7.
11. Bromander A, Holmgren J, Lycke N. Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro. J. Immunol. 1991; 146: 2908-14.
12. Lycke N, Severinson E, Strober W. Cholera toxin acts synergistically with IL-4 to promote IgG1 switch differentiation. J. Immunol. 1990; 145: 3316-24.
13. Lycke N, Strober W. Cholera toxin promotes B cell isotype differentiation. J. Immunol. 1989; 142: 3781-7.
14. Marinaro M, Staats HF, Hiroi T et al. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 1995; 155: 4621-9.
15. McGee DW, Elson CO, McGhee JR. Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: Mode of action and augmenting effect of inflammatory cytokines. Infect. Immun. 1993; 61: 4637-44.
16. Munoz E, Zubiaga AM, Merrow M, Sauter NP, Huber BT. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: Role of cAMP in T cell proliferation. J. Exp. Med. 1990; 172: 95-103.
17. Clements JD, Hartzog NM, Lyon FL. Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens. Vaccine 1988; 6: 269-77.
18. Silbart LK, McAleer F, Rasmussen MV et al. Selective induction of mucosal immune responses to 2-acetylaminofluorene. Anticancer Res. 1996; 16: 651-60.
19. Keren DF, Elliott HL, Brown GD, Yardley JH. Atrophy of villi with hypertrophy and hyperplasia of Paneth cells in isolated (Thiry-Vella) ileal loops in rabbits. Light-microscopic studies. Gastroenterology 1975; 68: 83-93.
20. Keren DF, Holt PS, Collins HH, Gemski P, Formal SB. Variables affecting local immune response in ileal loops: Role of immunization schedule, bacterial flora, and postsurgical inflammation. Infect. Immun. 1980; 28: 950-6.
21. Chu FS, Hsai MTS, Sun P. Preparation of and characterization of aflatoxin B1-1-(O-carboxymethyl)-oxime. J. Assoc. Off. Anal. Chem. 1977; 60: 791-94.
22. 1. Appl. Environ. Microbiol. 1997; 33: 1125-8.
23. 1: Specific antibodies and their use in radioimmunoassay. J. Natl Cancer Inst. 1976; 56: 591-5.
24. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248-54.
25. Davies MDJ, Parrott DMV. Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine. GUT 1981; 22: 481-8.
26. Czerkinski CC, Nilsson L-A, Nygren H, Ouchterlony O, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 1983; 65: 109-21.
27. Guesdon JL, Ternynck T, Avrameas S. The use of avidinbiotin interaction in immunoenzymatic techniques. J. Histochem. Cytochem. 1979; 27: 1131-9.
28. Moller G, Gronowicz E, Persson U et al. Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen. J. Exp. Med. 1976; 143: 1429-38.