Heterogeneity of gonadoblastoma germ cells: Similarities with immature germ cells, spermatogonia and testicular carcinoma in situ cells

Histopathology

Volumn 30, Issue 2, 1997, Pages 177-186

  Jorgensen N ^a   Muller J ^a   Jaubert, F ^b   Clausen, O P ^c   Skakkebaek N E ^a  

^a Rigshospitalet   (Denmark)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

gonadoblastoma; immature germ cells; spermatogonia; testicular carcinoma in situ

Indexed keywords

ADOLESCENT; ADULT; ANEUPLOIDY; ARTICLE; CARCINOMA IN SITU; CLINICAL ARTICLE; CONTROLLED STUDY; GERM CELL; GONADAL DYSGENESIS; GONADOBLASTOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SPERMATOGONIUM; TESTIS CARCINOMA;

EID: 0031040644     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.1997.d01-580.x     Document Type: Article

References (41)

1. Scully RE. Gonadoblastoma. A review of 74 cases. Cancer 1970; 25; 1340-1356.
2. Damjanov I, Klauber G. Microscopic gonadoblastoma in dysgenetic gonad of an infant. An ultrastrucural study. Urology 1980; 15; 605-609.
3. Robboy SJ, Miller T, Donnahoe PK et al. Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinico-pathologic analysis of 21 cases. Hum. Pathol. 1982; 13; 700-716.
4. Park IJ, Pyetta JC, Jones HW, Woodruff JD. Gonadoblastoma in a true hermaphrodite with 46 XY genotype. Obstet. Gynecol. 1972; 40; 466-472.
5. Mandell J, Stevens PS, Fried FA. Childhood gonadoblastoma and seminoma in a dysgenetic cryptorchid gonad. J. Urol. 1977; 117; 674-675.
6. Spear GS, Martin CG. Fetal gonadoblastoid testicular dysplasia. Hum. Pathol. 1986; 17; 531-533.
7. Hung W, Randolph JG, Chandra R, Belman AB. Gonadoblastoma in dysgenetic testis causing male pseudohermaphroditism in newborn. Urology 1981; 17; 584-587.
8. Berkovitz GD. Abnormalities of gonadal determination and differentiation. Semin. Perinatol, 1992; 16; 289-298.
9. Müller J, Visfeldt J, Philip J, Skakkebæk NE. Carcinoma in situ, gonadoblastoma, and early invasive neoplasia in a nine-year-old girl with 46, XY gonadal dysgenesis. APMIS 1992; 100; 170-174.
10. Skakkebæk NE. Possible carcinoma-in-situ of the testis. Lancet 1972; ii; 516-517.
11. Skakkebæk NE, Berthelsen JG, Giwercman A, Müller J. Carcinomain-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int. J. Androl. 1987; 10; 19-28.
12. Skakkebæk NE. Atypical germ cells in the adjacent 'normal' tissue of testicular tumours. APMIS 1975; 83; 127-130.
13. Holstein AF, Schütte B, Becker H, Hartmann M. Morphology of normal and malignant germ cells. Int. J. Androl. 1987; 10; 1-18.
14. Müller J, Skakkebæk NE. Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis. Int. J. Androl. 1981; suppl. 4; 211-221.
15. Müller J, Skakkebæk NE, Nielsen OH, Græm N. Cryptorchidism and testis cancer. Atypical infantile germ cells followed by carcinoma in situ and invasive carcinoma in adulthood. Cancer 1984; 54; 629-634.
16. Jacobsen GK, Nørgaard-Pedersen B. Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. APMIS 1984; 92; 323-329.
17. Giwercman A, Cantell L, Marks A. Placental-like alkaline phosphatase as a marker of carcinoma-in-situ of the tesits. Comparison with monoclonal antibodies M2A and 43-9F, APMIS 1991; 99; 586-594.
18. Rajpert-De Meyts E, Skakkebæk NE. Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. Int. J. Androl. 1994; 17; 85-92.
19. Giwercman A, Andrews PW, Jørgensen N, Müller J. Græm N, Skakkebæk NE. Immunohistochemical expression of embryonal marker TRA-1-60 in carcinoma in situ and germ cell tumors of the testis. Cancer 1993; 72; 1308-1314.
20. Giwercman A, Lindenberg S, Kimber SJ, Andersson T, Müller J, Skakkebæk NE. Monoclonal antibody 43-9F as a sensitive immunohistochemical marker of carcinoma in situ of human testis. Cancer 1990; 65; 1135-1142.
21. Giwercman A, Marks A, Bailey D, Baumal R, Skakkebæk NE. A monoclonal antibody as a marker for carcinoma in situ germ cells of the human adult testis. APMIS 1988; 96; 667-670.
22. Müller J, Skakkebæk NE. Testicular carcinoma in situ in children with androgen insensitivity (testicular feminisation) syndrome. Br. Med. J. 1984; 288; 1419-1420.
23. Müller J, Skakkebæk NE, Ritzén EM, Plöen L, Petersen KE. Carcinoma in situ of the testis in children with 45, X/46, XY gonadal dysgenesis. J. Pediatr. 1985; 106; 431-436.
24. Jørgensen N, Rajpert-De Meyts E, Græm N, Müller J. Giwercman A, Skakkebœk NE. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells. Lab. Invest. 1995; 72; 223-231.
25. Yarden Y, Kuang W-J, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A. Human proto-oncogene c-kit: a new surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 1987; 6; 3341-3351.
26. Andrews PW, Banting G, Damjanov I, Arnaud D, Avner P. Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Hybridoma 1984; 3; 347-361.
27. Müller J, Skakkebœk NE, Lundsteen C. Aneuploidy as a marker for carcinoma-in-situ of the testis. APMIS 1981; 89; 67-68.
28. Gaub J, Auer G, Zetterberg A. Quantitative cytochemical aspects of a combined Feulgen-naphtol. yellow S staining procedure for the simultaneous determination of nuclear and cytoplasmaic proteins and DNA in mammalian cells. Exp. Cell Res. 1975; 92; 323-332.
29. Sandritter W, Carl M, Ritter W. Cytophotometric measurements of the DNA content of human malignant tumors by means of the Feulgen reaction. Acta Cytol. 1966; 10; 26-30.
30. Vahs W, Zur Problematik der FEULGEN-Cytophotometrie (DNS) an Schnittpräparaten. Microscopia Acta 1973; 74; 36-42.
31. Böhm N, Sandritter W, Grundmann E, Kirsten WH, editors. DNA in human tumors: a cytophotometric study. In Current Topics in Pathology. Berlin: Springer-Verlag, 1975; 152-219.
32. Roth LM, Eglen DE, Gonadoblastoma. Immunohistochemical and ultrastructural observations. Int. J. Gyn. Pathol. 1989; 8; 72-81.
33. Damjanov I, Drobnjak P, Grizelj V. Ultrastructure of Gonadoblastoma. Arch. Pathol 1975; 99; 25-31.
34. Ishida T, Ragatz GE, Okagaki T. Gonadoblastoma. Ultrastructural Evidence for Testicular Origin. Cancer 1976; 37; 1770-81.
35. Mackay AM, Pettigrew N, Symington T, Neville I. Tumors of dysgenetic gonads (gonadoblastoma): Ultrastructural and steroidogenic aspects. Cancer 1974; 34; 1108-1125.
36. Manivel JC, Jessurun J, Wick MR, Dehner LP. Placental alkaline phosphatase immunoreactivity in testicular germ-cell neoplasms. Am. J. Surg. Pathol 1987; 11; 21-29.
37. Jørgensen N, Giwercman A, Müller J, Skakkebæk NE. Immunohistochemical markers of carcinoma in situ of the testis also expressed in normal infantile germ cells. Histopathology 1993; 22; 373-378.
38. Page DC, Hypothesis: A Y-chromosome gene causes gonadoblastoma in dysgenetic gonads. Development 1987; suppl, 101; 151-155.
39. Josso N, Legeai L, Forest MG, Chaussain J-L, Brauner R. An enzyme linked immunoassay for anti-Müllerian hormone: a new tool. for the evaluation of testicular function in infants and children. J. Clin. Endocrinol. Metab. 1990; 70; 23-27.
40. Jacobsen GK, Henriksen OB, von der Maase H. Carcinoma in situ of testicular tissue adjacent to malignant germ-cell tumors: A study of 105 cases. Cancer 1981; 47; 2660-2662.
41. Berthelsen JG, Skakkebæk NE. Value of testicular biopsy in diagnosing carcinoma in situ testis. Scand. J. Urol. Nephrol. 1981; 15; 165-168.