Phosphorylation of myosin light chain in resting platelets from NIDDM patients is enhanced: Correlation with spontaneous aggregation

Diabetes

Volumn 46, Issue 3, 1997, Pages 488-493

  Fukuda, Koichiro ^a   Ozaki, Yukio ^c   Satoh, Kaneo ^c   Kume, Shoji ^c   Tawata, Masato ^c   Onaya, Toshimasa ^c   Sakurada, Katsuhiko ^b   Seto, Minoru ^a,d   Sasaki, Yasuharu ^b  

^a Life Science Center   (Japan)

^b Life Science Center   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

^d ASAHI CHEMICAL INDUSTRY CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN LIGHT CHAIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

EID: 0031040476     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.3.488     Document Type: Article

References (25)

1. Kwaan HC, Colwell JA, Cruz S, Suwanwela N, Dobbie JG: Increased platelet aggregation in diabetes mellitus. J Lab Clin Med 80:236-246, 1972
2. Halushka PV, Rogers RC, Loadholt CB, Colwell JA: Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med 97:87-96, 1981
3. Colwell JA, Winocour PD, Lopes-Virella M, Halushka PV: New concepts about the pathogenesis of atherosclerosis in diabetes mellitus. Am J Med 30:67-80, 1983
4. Watanabe J, Umeda F, Wakasugi H, Ibayashi H: Effect of vitamin E on platelet aggregation in diabetes mellitus. Thromb Haemostas 51:313-316, 1984
5. Mandai S, Sarode R, Dash S, Dash RJ: Hyperaggregation of platelets detected by whole blood platelet aggregometry in newly diagnosed noninsulin-dependent diabetes mellitus. Am J Clin Pathol 100:103-107, 1993
6. Eldor A, Merin S, Bar-On H: The effect of streptozotocin diabetes on platelet function in rats. Thromb Res 13:703-714, 1978
7. 2+ mobilization, and protein phosphorylation in platelets from NIDDM patients. Diabetes 39:1561-1568, 1990
8. Kaplan KL, Owen J: Plasma levels of β-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo. Blood 57:199-202, 1981
9. Abrams C, Shattil SJ: Immunological detection of activated platelets in clinical disorders. Thromb Haemostasis 65:467-473, 1991
10. Janes SL, Kyle PM, Redman C, Goodall AH: Flow cytometric detection of activated platelets in pregnant women prior to the development of pre-eclampsia. Thromb Haemostasis 74:1059-1063, 1995
11. Naka M, Nishikawa M, Adelstein RS, Hidaka H: Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains. Nature 306:490-492, 1983
12. Sasaki Y, Uchida T, Sasaki Y: A variant derived from rabbit aorac smooth muscle: phenotype modulation and restoration of smooth muscle characteristics in cells in culture. J Biochem 106:1009-1018, 1989
13. Ozaki Y, Satoh K, Yatomi Y, Yamamoto T, Shirasawa Y, Kume S: Detection of platelet aggregates with a parade counting method using light scattering. Anal Biochem 218:284-294, 1994
14. Walsh MP, Hinkins S, Dabrowska R, Hartshome DJ: Smooth muscle myosin light chain kinase. Methods Enzymol 99:279-288, 1983
15. Hathaway DR, Haeberle JR: Selective purification of 20,000-Da light chain of smooth muscle myosin. Anal Biochem 135:37-43, 1983
16. Yazawa M, Sakuma M, Yagi K: Calmodulins from muscles of marine inverts brates, scallop and sea anemone. J Biochem 87:1313-1320, 1980
17. 4. Nature 227:680-685, 1970
18. Sakurada K, Ikuhara T, Seto M, Sasaki Y: An antibody for phosphorylated myosin light chain of smooth muscle: application to a biochemical study. J Biochem 115:18-21, 1994
19. Ikebe M, Hartshome DJ: Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. J Biol Chem 260:10027-10031, 1985
20. Ikebe M, Hartshome DJ, Elzinga M: Phosphorylation of the 20000-Dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. J Biol Chem 262:9569-9573, 1987
21. Saitoh M, Naka M, Hidaka H: The modulatory role of myosin light chain phosphorylation in human platelet activation. Biochem Biophys Res Commun 140:280-287, 1986
22. Menys VC, Bhatnagar D, Mackness MI, Durrington PN: Spontaneous platelet aggregation in whole blood is increased in non-insulin-dependent diabetes mellitus and in female but not male patients with primary dyslipidemia. Atherosclerosis 112:115-122, 1995
23. Hathaway DR, Adelstein RS: Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity. Proc Natl Acad Sci USA 76:1653-1657, 1979
24. Ichikawa K, Ito M, Hartshome DJ: Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity. J Biol Chem 271:4733-4740, 1996
25. Ishizaki T, Maekawa M, Pujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to niyotonic dystrophy kinase. EMBO J 15:1885-1893, 1996