메뉴 건너뛰기




Volumn 32, Issue 1, 1997, Pages 29-38

Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. II. Cytokine production and in vivo efficacy of glioma-sensitized lymphocytes

Author keywords

interferon; Activation; Culture; Cytotoxicity; Glioma; Immunotherapy; Lymphocyte; Signal transduction

Indexed keywords

BRYOSTATIN 1; CHROMIUM 51; CYTOKINE; GAMMA INTERFERON; IONOMYCIN; RECOMBINANT INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 0031040474     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005771717409     Document Type: Article
Times cited : (8)

References (47)
  • 2
    • 0025004766 scopus 로고
    • Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes. A review of pre-clinical and clinical investigations
    • Merchant RE, Ellison MD, Young HF: Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes. A review of pre-clinical and clinical investigations. J Neuro-Oncol 8: 173-188, 1990
    • (1990) J Neuro-Oncol , vol.8 , pp. 173-188
    • Merchant, R.E.1    Ellison, M.D.2    Young, H.F.3
  • 3
    • 0024210594 scopus 로고
    • Intralesional infusion of lymphokine-activated killer (LAK) cells and recombinant interleukin-2 (rIL-2) for the treatment of patients with malignant brain tumor
    • Merchant RE, Merchant LH, Cook SHS, McVicar DW, Young HF: Intralesional infusion of lymphokine-activated killer (LAK) cells and recombinant interleukin-2 (rIL-2) for the treatment of patients with malignant brain tumor. Neurosurgery 23: 725-732, 1988
    • (1988) Neurosurgery , vol.23 , pp. 725-732
    • Merchant, R.E.1    Merchant, L.H.2    Cook, S.H.S.3    McVicar, D.W.4    Young, H.F.5
  • 4
    • 0026081832 scopus 로고
    • Characterization of interleukin-2-initiated versus OKT3-initiated human tumor-infiltrating lymphocytes from glioblastoma multi-forme: Growth characteristics, cytolytic activity, and cell phenotype
    • Grimm EA, Brunner JM, Carinhas J, Koppen JA, Loudon WG, Owen-Schaub L, Steck PA, Moser RP: Characterization of interleukin-2-initiated versus OKT3-initiated human tumor-infiltrating lymphocytes from glioblastoma multi-forme: growth characteristics, cytolytic activity, and cell phenotype. Cancer Immunol Immunother 32: 391-399, 1991
    • (1991) Cancer Immunol Immunother , vol.32 , pp. 391-399
    • Grimm, E.A.1    Brunner, J.M.2    Carinhas, J.3    Koppen, J.A.4    Loudon, W.G.5    Owen-Schaub, L.6    Steck, P.A.7    Moser, R.P.8
  • 5
    • 0026672382 scopus 로고
    • Successful treatment of malignant rat glioma with cytotoxic T-lymphocytes
    • Holladay FP, Heitz T, Chen YL, Chiga M, Wood GW: Successful treatment of malignant rat glioma with cytotoxic T-lymphocytes. Neurosurgery 31: 528-533, 1992
    • (1992) Neurosurgery , vol.31 , pp. 528-533
    • Holladay, F.P.1    Heitz, T.2    Chen, Y.L.3    Chiga, M.4    Wood, G.W.5
  • 6
    • 0022531435 scopus 로고
    • Immunohistochemical analysis of infiltrating lymphocytes in central nervous system tumors
    • Paine JT, Janda H, Yamasaki T, Yamashita J, Miyatake S: Immunohistochemical analysis of infiltrating lymphocytes in central nervous system tumors. Neurosurgery 18: 766-772, 1986
    • (1986) Neurosurgery , vol.18 , pp. 766-772
    • Paine, J.T.1    Janda, H.2    Yamasaki, T.3    Yamashita, J.4    Miyatake, S.5
  • 7
    • 0024516737 scopus 로고
    • Antitumor activity and surface phenotypes of human glioma-infiltrating lymphocytes after in vitro expansion in the presence of interleukin 2
    • Sawamura Y, Hosokawa M, Kuppner, Kobayashi H, Aida T, Abe H, de Tribolet N: Antitumor activity and surface phenotypes of human glioma-infiltrating lymphocytes after in vitro expansion in the presence of interleukin 2. Cancer Res 49: 1843-1849, 1989
    • (1989) Cancer Res , vol.49 , pp. 1843-1849
    • Sawamura, Y.1    Hosokawa, M.2    Kuppner3    Kobayashi, H.4    Aida, T.5    Abe, H.6    De Tribolet, N.7
  • 8
    • 0025630441 scopus 로고
    • Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L gliosarcoma: Allogeneic cytotoxic T lymphocytes prevent tumor take
    • Kruse CA, Lillehei KO, Mitchell DH, Kleinschmidt-De-Masters B, Bellgrau D : Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L gliosarcoma: Allogeneic cytotoxic T lymphocytes prevent tumor take. Proc Nat Acad Sci USA 87: 9577-9581, 1990
    • (1990) Proc Nat Acad Sci USA , vol.87 , pp. 9577-9581
    • Kruse, C.A.1    Lillehei, K.O.2    Mitchell, D.H.3    Kleinschmidt-De-Masters, B.4    Bellgrau, D.5
  • 10
    • 0027979670 scopus 로고
    • Generation of cytotoxic immune responses during the progression of a rat glioma
    • Holladay FP, Choudhuri R, Heitz T, Wood GW: Generation of cytotoxic immune responses during the progression of a rat glioma. J Neurosurg 80: 90-96, 1994
    • (1994) J Neurosurg , vol.80 , pp. 90-96
    • Holladay, F.P.1    Choudhuri, R.2    Heitz, T.3    Wood, G.W.4
  • 11
    • 0027222829 scopus 로고
    • Generation of cellular immune responses against a glioma-associated antigen(s)
    • Holladay FP, Wood GW: Generation of cellular immune responses against a glioma-associated antigen(s). J Neuroimmunol 44: 27-32, 1993
    • (1993) J Neuroimmunol , vol.44 , pp. 27-32
    • Holladay, F.P.1    Wood, G.W.2
  • 12
    • 0025856813 scopus 로고
    • Identification of unique murine tumor associated antigens by tumor infiltrating lymphocytes using tumor specific secretion of interferon-γand tumor necrosis factor
    • Barth RJ, Mule JJ, Asher AL, Sanda MG, Rosenberg SA: Identification of unique murine tumor associated antigens by tumor infiltrating lymphocytes using tumor specific secretion of interferon-γand tumor necrosis factor. J Immunol Method 140: 269-279, 1991
    • (1991) J Immunol Method , vol.140 , pp. 269-279
    • Barth, R.J.1    Mule, J.J.2    Asher, A.L.3    Sanda, M.G.4    Rosenberg, S.A.5
  • 14
    • 0025782503 scopus 로고
    • Phenotype and functional activity of tumor-infiltrating lymphocytes isolated from immunogenic and nonimmunogenic rat brain tumors
    • Tzeng JJ, Barth RF, Orosz CG, James SM: Phenotype and functional activity of tumor-infiltrating lymphocytes isolated from immunogenic and nonimmunogenic rat brain tumors. Cancer Res 51: 2372-2378, 1991
    • (1991) Cancer Res , vol.51 , pp. 2372-2378
    • Tzeng, J.J.1    Barth, R.F.2    Orosz, C.G.3    James, S.M.4
  • 15
    • 0026043705 scopus 로고
    • T-cells from tumor-immune mice nonspecifically expanded in vitro with anti-CD3 plus IL-2 retain specific function in vitro and can eradicate disseminated leukemia in vivo
    • Crossland KD, Lee VK, Chen W, Riddell SR, Greenberg PD, Cheever MA : T-cells from tumor-immune mice nonspecifically expanded in vitro with anti-CD3 plus IL-2 retain specific function in vitro and can eradicate disseminated leukemia in vivo. J Immunol 146: 4414-4420, 1991
    • (1991) J Immunol , vol.146 , pp. 4414-4420
    • Crossland, K.D.1    Lee, V.K.2    Chen, W.3    Riddell, S.R.4    Greenberg, P.D.5    Cheever, M.A.6
  • 16
    • 0025681044 scopus 로고
    • Activation and expansion of tumor-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies
    • Nijhuis EWP, Kemenade EW, Figdor CG, Van Lier RAW: Activation and expansion of tumor-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies. Cancer Immunol Immunother 32: 245-250, 1990
    • (1990) Cancer Immunol Immunother , vol.32 , pp. 245-250
    • Nijhuis, E.W.P.1    Kemenade, E.W.2    Figdor, C.G.3    Van Lier, R.A.W.4
  • 18
    • 0026573371 scopus 로고
    • Activation and growth of murine tumor-specific T-cells which have in vivo activity with Bryostatin-1
    • Tuttle TM, Inge TH, Bethke KP, McCrady CW, Pettit GR, Bear HD: Activation and growth of murine tumor-specific T-cells which have in vivo activity with Bryostatin-1. Cancer Res 52: 548-553, 1992
    • (1992) Cancer Res , vol.52 , pp. 548-553
    • Tuttle, T.M.1    Inge, T.H.2    Bethke, K.P.3    McCrady, C.W.4    Pettit, G.R.5    Bear, H.D.6
  • 20
    • 0010543768 scopus 로고
    • Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester induced differentiation of human promyelocytic progenitor cells HL-60
    • Kraft AS, Smith JB, Berkow RL: Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester induced differentiation of human promyelocytic progenitor cells HL-60. Proc Natl Acad Sci USA 83: 1334-1338, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1334-1338
    • Kraft, A.S.1    Smith, J.B.2    Berkow, R.L.3
  • 21
    • 0026012174 scopus 로고
    • Activation and in vitro expansion of tumor-reactive T lymphocytes from lymph nodes draining human primary breast cancers
    • Hoover SK, Frank JL, McCrady CW, McKinnon JG, Bear HD: Activation and in vitro expansion of tumor-reactive T lymphocytes from lymph nodes draining human primary breast cancers. J Surg Oncol 46: 117-124, 1991
    • (1991) J Surg Oncol , vol.46 , pp. 117-124
    • Hoover, S.K.1    Frank, J.L.2    McCrady, C.W.3    McKinnon, J.G.4    Bear, H.D.5
  • 22
    • 0031040621 scopus 로고    scopus 로고
    • Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. I. Characterization and in vivo anti-tumor activity of glioma-sensitized lymphocytes
    • in press
    • Baldwin NB, Rice CD, Tuttle TM, Bear HD, Hirsch JI, Merchant RE: Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. I. Characterization and in vivo anti-tumor activity of glioma-sensitized lymphocytes. J Neuro-Oncol, in press, 1996
    • (1996) J Neuro-Oncol
    • Baldwin, N.B.1    Rice, C.D.2    Tuttle, T.M.3    Bear, H.D.4    Hirsch, J.I.5    Merchant, R.E.6
  • 23
    • 8044258792 scopus 로고
    • Adoptive immunotherapy of malignant glioma using tumor-sensitized T lymphocytes
    • in press
    • Merchant RE, Baldwin NB, Rice CD, Bear HD: Adoptive immunotherapy of malignant glioma using tumor-sensitized T lymphocytes. Neurol Res, in press, 1995
    • (1995) Neurol Res
    • Merchant, R.E.1    Baldwin, N.B.2    Rice, C.D.3    Bear, H.D.4
  • 24
    • 8044220693 scopus 로고    scopus 로고
    • A mixture of the MANOVA and GMNOVA models
    • Elswick RK, Chinchilli V: A mixture of the MANOVA and GMNOVA models. Commun Statist 14: 3075-3089
    • Commun Statist , vol.14 , pp. 3075-3089
    • Elswick, R.K.1    Chinchilli, V.2
  • 25
    • 0023719678 scopus 로고
    • Human natural lymphocytic effector cells: Definition, analysis of activity, and clinical effectiveness
    • Ortaldo JR, Longo DL: Human natural lymphocytic effector cells: Definition, analysis of activity, and clinical effectiveness. JNCI 80: 999-1010, 1988
    • (1988) JNCI , vol.80 , pp. 999-1010
    • Ortaldo, J.R.1    Longo, D.L.2
  • 26
    • 0019523223 scopus 로고
    • Characteristics of human large granular lymphocytes and relationship to natural killer and K cells
    • Timonen T, Ortaldo JR, Herberman RB: Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J Exp Med 153: 569-582, 1981
    • (1981) J Exp Med , vol.153 , pp. 569-582
    • Timonen, T.1    Ortaldo, J.R.2    Herberman, R.B.3
  • 27
    • 0024988334 scopus 로고
    • Gene transfer into humans - Immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
    • Rosenberg SA, Lotze MT, Yang JC, Topalian SL, Merino MJ, Culver K, Miller AD, Blaese RM, Anderson WF: Gene transfer into humans - immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 323: 570-578, 1990
    • (1990) N Engl J Med , vol.323 , pp. 570-578
    • Rosenberg, S.A.1    Lotze, M.T.2    Yang, J.C.3    Topalian, S.L.4    Merino, M.J.5    Culver, K.6    Miller, A.D.7    Blaese, R.M.8    Anderson, W.F.9
  • 28
    • 0023581885 scopus 로고
    • Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion
    • Ellison MD, Povlishock JT, Merchant RE: Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion. Cancer Res 47: 5765-5770, 1987
    • (1987) Cancer Res , vol.47 , pp. 5765-5770
    • Ellison, M.D.1    Povlishock, J.T.2    Merchant, R.E.3
  • 29
    • 0022534622 scopus 로고
    • Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin-2
    • Rosenstein M, Ettinghausen SE, Rosenberg SA : Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin-2. J Immunol 137: 1735-1742, 1986
    • (1986) J Immunol , vol.137 , pp. 1735-1742
    • Rosenstein, M.1    Ettinghausen, S.E.2    Rosenberg, S.A.3
  • 30
    • 0024349512 scopus 로고
    • Histopathological and blood-brain barrier changes in rats induced by intracerebral injection of human recombinant interleukin-2
    • Watts RG, Wright JL, Atkinson LL, Merchant RE: Histopathological and blood-brain barrier changes in rats induced by intracerebral injection of human recombinant interleukin-2. Neurosurgery 25: 202-208, 1989
    • (1989) Neurosurgery , vol.25 , pp. 202-208
    • Watts, R.G.1    Wright, J.L.2    Atkinson, L.L.3    Merchant, R.E.4
  • 32
    • 0024465820 scopus 로고
    • Human tumor-infiltrating lymphocyte (TIL) cytotoxicity facilitated by anti-T-cell receptor antibody
    • Schoof DD, Jung SE, Eberlein TJ : Human tumor-infiltrating lymphocyte (TIL) cytotoxicity facilitated by anti-T-cell receptor antibody. Int J Cancer 44: 219-224, 1989
    • (1989) Int J Cancer , vol.44 , pp. 219-224
    • Schoof, D.D.1    Jung, S.E.2    Eberlein, T.J.3
  • 33
    • 0023940253 scopus 로고
    • Generation of therapeutic T lymphocytes from tumor bearing mice by in vitro sensitization. Culture requirements and characterization of immunospecificity
    • Chou T, Chang A, Shu S: Generation of therapeutic T lymphocytes from tumor bearing mice by in vitro sensitization. Culture requirements and characterization of immunospecificity. J Immunol 140: 2453-2461, 1988
    • (1988) J Immunol , vol.140 , pp. 2453-2461
    • Chou, T.1    Chang, A.2    Shu, S.3
  • 34
    • 0025324181 scopus 로고
    • Selective expansion of specific anti-tumor CD8+ cytotoxic T-lymphocyte clones in bulk culture of tumor-infiltrating lymphocytes from a melanoma patient: Cytotoxic activity and T-cell receptor gene rearrangements
    • Gervois N, Heuze F, Diez E, Jotereau F: Selective expansion of specific anti-tumor CD8+ cytotoxic T-lymphocyte clones in bulk culture of tumor-infiltrating lymphocytes from a melanoma patient: cytotoxic activity and T-cell receptor gene rearrangements. Eur J Immunol 20: 825-831, 1990
    • (1990) Eur J Immunol , vol.20 , pp. 825-831
    • Gervois, N.1    Heuze, F.2    Diez, E.3    Jotereau, F.4
  • 35
    • 0024593992 scopus 로고
    • Failure of specific adoptive immunotherapy owing to survival and outgrowth of variant cells
    • Hines DL: Failure of specific adoptive immunotherapy owing to survival and outgrowth of variant cells. Cancer Immunol Immunother 28: 241-247, 1989
    • (1989) Cancer Immunol Immunother , vol.28 , pp. 241-247
    • Hines, D.L.1
  • 37
    • 0027439350 scopus 로고
    • In vivo antitumor efficacy of tumor-draining lymph node cells activated with nonspecific T-cell reagents
    • Shu S, Sussman JJ, Chang AE: In vivo antitumor efficacy of tumor-draining lymph node cells activated with nonspecific T-cell reagents. J Immunother 14: 279-285, 1993
    • (1993) J Immunother , vol.14 , pp. 279-285
    • Shu, S.1    Sussman, J.J.2    Chang, A.E.3
  • 38
    • 0026525802 scopus 로고
    • Systemic treatment with murine recombinant interleukin-1β inhibits the growth and progression of malignant glioma in the rat
    • Rice CD, Merchant RE: Systemic treatment with murine recombinant interleukin-1β inhibits the growth and progression of malignant glioma in the rat. J Neuro-Oncol 13: 43-55, 1992
    • (1992) J Neuro-Oncol , vol.13 , pp. 43-55
    • Rice, C.D.1    Merchant, R.E.2
  • 39
    • 0023886269 scopus 로고
    • Modulation of class I and class II histocompatibility antigens on human T cell lines by IFN-γ
    • Gerrard TL, Dyer DR, Zoom KC, Nedden DZ, Siegel JP: Modulation of class I and class II histocompatibility antigens on human T cell lines by IFN-γ. J Immunol 140: 3450-3455, 1988
    • (1988) J Immunol , vol.140 , pp. 3450-3455
    • Gerrard, T.L.1    Dyer, D.R.2    Zoom, K.C.3    Nedden, D.Z.4    Siegel, J.P.5
  • 40
    • 0020560102 scopus 로고
    • Interferon-γ induces enhanced expression of Ia and H-2 antigen on lymphoid, macrophage, and myeloid cell lines
    • Wong GHW, Clark-Lewis I, McKimm-Breschkin JL, Harris AW, Schrader JW: Interferon-γ induces enhanced expression of Ia and H-2 antigen on lymphoid, macrophage, and myeloid cell lines. J Immunol 131: 788-793, 1983
    • (1983) J Immunol , vol.131 , pp. 788-793
    • Wong, G.H.W.1    Clark-Lewis, I.2    McKimm-Breschkin, J.L.3    Harris, A.W.4    Schrader, J.W.5
  • 41
    • 0022354841 scopus 로고
    • Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes
    • Flyer DC, Burakoff SJ, Faller DV: Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes. J Immunol 135: 2287-2292, 1985
    • (1985) J Immunol , vol.135 , pp. 2287-2292
    • Flyer, D.C.1    Burakoff, S.J.2    Faller, D.V.3
  • 42
    • 0020580976 scopus 로고
    • Interleukin-2 mediated immune interferon (IFN-γ) production by human T cells and T cell subsets
    • Kasahara T, Hooks JJ, Dougherty SF, Oppenheim JJ: Interleukin-2 mediated immune interferon (IFN-γ) production by human T cells and T cell subsets. J Immunol 130: 1784-1789, 1983
    • (1983) J Immunol , vol.130 , pp. 1784-1789
    • Kasahara, T.1    Hooks, J.J.2    Dougherty, S.F.3    Oppenheim, J.J.4
  • 43
    • 0020539090 scopus 로고
    • Recombinant mouse γ-interferon induces the prime step in macrophage activation for tumor cell killing
    • Place JL, Russel SW, Torres BA, Johnson HM, Gray PW: Recombinant mouse γ-interferon induces the prime step in macrophage activation for tumor cell killing. J Immunol 130: 2001-2013, 1983
    • (1983) J Immunol , vol.130 , pp. 2001-2013
    • Place, J.L.1    Russel, S.W.2    Torres, B.A.3    Johnson, H.M.4    Gray, P.W.5
  • 44
    • 0023684873 scopus 로고
    • Obligatory role of IFN-γ in induction of lymphokine-activated and T-lymphocyte killer, but not in boosting of natural cytotoxicity
    • Giovarelli M, Santoni A, Jemma C, Musso T, Ginffrida AM, Cavallo G, Landofo S, Forni G: Obligatory role of IFN-γ in induction of lymphokine-activated and T-lymphocyte killer, but not in boosting of natural cytotoxicity. J Immunol 141: 2831-2836, 1988
    • (1988) J Immunol , vol.141 , pp. 2831-2836
    • Giovarelli, M.1    Santoni, A.2    Jemma, C.3    Musso, T.4    Ginffrida, A.M.5    Cavallo, G.6    Landofo, S.7    Forni, G.8
  • 45
    • 0025008902 scopus 로고
    • Efficient tumor suppression by glioma-specific murine cytotoxic T lymphocytes transfected with interferon-γ gene
    • Miyatake S, Nishihara K, Kikuchi H, Yamashita J, Namba Y, Hanaoka M, Watanabe Y: Efficient tumor suppression by glioma-specific murine cytotoxic T lymphocytes transfected with interferon-γ gene. JNCI 82: 217-220, 1990
    • (1990) JNCI , vol.82 , pp. 217-220
    • Miyatake, S.1    Nishihara, K.2    Kikuchi, H.3    Yamashita, J.4    Namba, Y.5    Hanaoka, M.6    Watanabe, Y.7
  • 46
    • 0023812994 scopus 로고
    • Augmentation of tumor targeting in a line of glioma-specific mouse cytotoxic T-lymphocytes by retroviral expression of mouse γ-IFN complementary DNA
    • Nishihara K, Miyatake K, Sakata T, Yamashita J, Kikuchi H, Kawade Y, Zu Y, Namba Y, Hanoka M, Watanabe Y: Augmentation of tumor targeting in a line of glioma-specific mouse cytotoxic T-lymphocytes by retroviral expression of mouse γ-IFN complementary DNA. Cancer Res 48: 4730-4735, 1988
    • (1988) Cancer Res , vol.48 , pp. 4730-4735
    • Nishihara, K.1    Miyatake, K.2    Sakata, T.3    Yamashita, J.4    Kikuchi, H.5    Kawade, Y.6    Zu, Y.7    Namba, Y.8    Hanoka, M.9    Watanabe, Y.10
  • 47
    • 0022534109 scopus 로고
    • Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon
    • Trinchieri G, Kobayashi M, Rosen M, Loudon R, Murphy M, Perussia B: Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. J Exp Med 164: 1206-1225, 1986
    • (1986) J Exp Med , vol.164 , pp. 1206-1225
    • Trinchieri, G.1    Kobayashi, M.2    Rosen, M.3    Loudon, R.4    Murphy, M.5    Perussia, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.