Targeted screening for elongation factor Tu binding antibiotics

Journal of Antibiotics

Volumn 50, Issue 1, 1997, Pages 22-26

  Selva, E ^a   Montanini, N ^a   Stella, S ^a   Soffientini, A ^a   Gastaldo, L ^a   Denaro, M ^a,b  

^a Gruppo Lepetit SpA   (Italy)

^b AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITHIAMYCIN; ANTIBIOTIC AGENT; CHLORAMPHENICOL; ELONGATION FACTOR TU; ERYTHROMYCIN; GE 2270; GE 37468; KANAMYCIN; MOCIMYCIN; PENICILLIN G; RIFAMPICIN; SPECTINOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG ANTAGONISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; PRIORITY JOURNAL;

EID: 0031040361     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.22     Document Type: Article

References (32)

1. SELVA, E.; G. BERETTA, N. MONTANINI, L. GASTALDO, P. FERRARI, R. LORENZETTI, P. LANDINI, B. P. GOLDSTEIN, M. BERTI, L. MONTANARO & M. DENARO: Antibiotic GE2270 A: A novel inhibitor of bacterial protein synthesis. I. Isolation and characterization. J. Antibiotics 44: 693-701, 1991
2. TAVECCHIA, P.; P. GENTILI, M. KURZ, C. SOTTANI, R. BONFICHI, S. LOCIURO & E. SELVA: Revised structure of the antibiotic GE 2270A. J. Antibiotics 47: 1564-1567, 1994
3. SELVA, E.; P. FERRARI, P. TAVECCHIA, L. COLOMBO, S. STELLA, E. RESTELLI, B. P. GOLDSTEIN, F. RIPAMONTI & M. DENARO: Components of the GE2270 complex produced by Planobispora rosea ATCC 53773. J. Antibiotics 48: 1039-1042, 1995
4. STELLA, S.; N. MONTANINI, F. LE MONNIER, P. FERRARI, L. COLOMBO, F. MARINELLI, P. LANDINI, I. CICILIATO, B. P. GOLDSTEIN, E. SELVA & M. DENARO: Antibiotic GE37468 A. A novel inhibitor of bacterial protein synthesis. I. Isolation and characterization. J. Antibiotics 48: 780-786, 1995
5. FERRARI, P.; L. COLOMBO, S. STEELA, E. SELVA & L. F. ZERILLI: Antibiotic GE37468 A: A new inhibitor of bacterial protein synthesis. II. Structure elucidation. J. Antibiotics 48: 1304-1311, 1995
6. SHIMANAKA, K.; N. KINOSHITA, H. IINUMA, M. HAMADA & T. TAKEUCHI: Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physicochemical properties, and antimicrobial activity. J. Antibiotics 47: 668-674, 1994
7. SHIMANAKA, K.; Y. TAKAHASHI, H. IINUMA, H. NAGANAWA & T. TAKEUCHI: Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D. J. Antibiotics 47: 1145-1152, 1994
8. SHIMANAKA, K.; Y. TAKAHASHI, H. IINUMA, H. NAGANAWA & T. TAKEUCHI: Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C. J. Antibiotics 47: 1153-1159, 1994
9. LANDINI, P.; M. BANDERA, B. P. GOLDSTEIN, F. RIPAMONTI, A. SOFFIENTINI, K. ISLAM & M. DENARO: Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin. Biochem. J. 283: 649-652, 1992
10. ANBORGH, P. H. & A. PARMEGGIANI: New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu. EMBO J. 10: 779-784, 1991
11. SHIMANAKA, K.; H. IINUMA, M. HAMADA, S. IKENO, K. S. TSUCHIYA, M. ARITA & M. HORI: Novel antibiotics, amythiamicins. IV. A mutation in the elongation factor Tu gene in a resistant mutant of B. subtilis. J. Antibiotics 48: 182-184, 1995
12. BERETTA, G.; F. LE MONNIER, E. SELVA & F. MARINELLI: A novel producer of the antibiotic kirromycin belonging to the genus Actinoplanes. J. Antibiotics 46: 1175-1177, 1993
13. SMITH, R. J.; D. H. WILLIAMS, J. C. J. BARNA, I. R. MCDERMOTT, K. D. HAEGELE, F. PIRIOU, J. WAGNER & W. HIGGINS: Structure revision of the antibiotic pulvomycin J. Am. Che. Soc. 107: 2849-2857, 1985
14. JACOBSON, G. R.& J.P. ROSENBUSCH: Affinity purification of elongation factors Tu and Ts. FEBS Letteres 79: 8-10, 1977
15. PARMEGGIANI, A. & G. M. SWART: Mechanism of action of kirromycin-like antibiotics. Ann. Rev. Microbiol. 39: 557-577, 1985
16. SELVA, E.; G. BERETTA, R. PALLANZA, B. P. GOLDSTEIN, M. BERTI, D. M. F. EDWARDS & M. DENARO: Antibiotic SB22484: A novel complex of the aurodox group. I. Taxonomy of the producing organism, isolation of the antibiotics and chemical and biological characterization. J. Antibiotics 43: 1349-1358, 1990
17. HALL, C. C.; J. D. WATKINS & N. H. GEORGOPAPADAKOU: Effects of elfamycins on elongation factor Tu from Escherichia coli and Staphylacoccus aureus. Antimic. Agents Chemother. 33: 322-325, 1989
18. EDWARDS, D. M. F.; E. SELVA, S. STELLA, L. F. ZERILLI & G. G. GALLO: Mass spectrometry technique for structure and novelty determination of kirromycin-like antibiotics. Biol. Mass Spectrom. 21: 51-59, 1992
19. WOLF, H.; D. HASSMANN & E. FISCHER: Pulvomycin, an inhibitor of protein biosynthesis preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA. Proc. Natl. Acad. Sci. U.S.A. 75: 5324-5328, 1978
20. FURANO, A. V.: Content of elongation factor Tu in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 72: 4780-4784, 1975
21. JACOBSON, G. R. & J. P. ROSEMBUSCH: Abundance and membrane association of elongation factor Tu in E. coli. Nature 261: 23-26, 1976
22. VOBIS, G.: Genus Planobispora Thiemann and Beretta 1968, 157AL. In BERGEY'S Manual of Systematic Bacteriology. Eds., S. T. WILLIAMS et al., Vol. 4, pp. 2536-2538, Williams & Wilkins, Baltimore, 1989
23. BERDY, J.: Thiazolyl peptides. In Handbook of antibiotic compounds. Ed., J. BERDY et al., Vol. IV/I, pp. 389-417, CRC Press Inc., Boca Raton, Florida, 1980
24. GOLDSTEIN, B. P.; M. BERTI, F. RIPAMONTI, A. RESCONI, R. SCOTTI & M. DENARO: In vitro activity of a new antibiotic, MDL 62,879 (GE2270 A). Antimicrob. Agents Chemother. 37: 741-745, 1993
25. LANDINI, P.; M. BANDERA, A. SOFFIENTINI & B. P. GOLDSTEIN: Sensitivity of elongation factor Tu (EF-Tu) from different bacterial species to the antibiotics efrotomycin, pulvomycin and MDL 62879. J. Gen. Microbiol. 139: 769-774, 1993
26. BIBIKOVA, M. V.; A. V. LAIKO, T. I. SELEZNEVA & I. N. KOVSHAROVA: On possibility of early identification of organisms producing polyenic antibiotics. Antibiotiky 20: 675-678, 1975
27. FUKUDA, H.; Y. KAWAKAMY & S. NAKAMURA: A method to screen anticholesterol substances produced by microbes and a new cholesterol oxidase produced by Streptomyces violascens. Chem. Pharm. Bull. 21: 2057-2060, 1973
28. RAKE, J. B.; R. GERBER, R. J. MEHTA, D. J. NEWMAN, Y. K. OH, C. PHELEN, M. C. SEARER, R. D. SITRIN & L. J. NISBET: Glycopeptide antibiotics: A mechanism based screen employng a bacterial cell wall receptor mimetic. J. Antibiotics 39: 58-67, 1986
29. BOSCH, L.; B. KRAAL, P. H. VAN DER MEIDE, F. J. DUISTERWINKEL & J. M. VAN NOORT: The elongation factotr EF-Tu and its two encoding genes. Progress in Nucleic Acid Research 30: 91-126, 1983
30. WIBORG, O.; C. ANDERSON, C. K. KNUDSEN, T. J. KRISTENSEN & B. F. C. CLARK: Toward an understanding of structure-function relationships of elongation factor Tu. Biotechnol. Appl. Biochem. 19: 3-15, 1994
31. NIETO, M. & H. R. PERKINS: The specificity of combination between ristocetins and peptides related to bacterial wall mucopeptide precursors. Biochem. J. 124: 845-852, 1971
32. OKABE, T.; B. D. YUAN, F. ISONO, I. SATO, H. FUKUZAWA, T. NISHIMURA & N. TANAKA: Studies on antineoplastic activity of naphtomycin, a naphtalenic ansamycin, and its mode of action. J. Antibiotics 38: 230-235, 1985