In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 2, 1997, Pages 298-307

  Ohba, Fuminori ^a   Nakamura Kamijo, Mayumi ^a   Watanabe, Nao Aki ^a   Katsu, Kanemasa ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 (1 HYDROXYETHYL) 1 METHYL 2 [(PYRROLIDIN 3 YLHYDROXYMETHYL)PYRROLIDIN 4 YLTHIO] 1 CARBAPEN 2 EM 3 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; CEFALORIDINE; CEFALOTIN; CEFCLIDIN; CEFLUPRENAM; CEFSULODIN; CEFTAZIDIME; CILASTATIN; CILASTATIN PLUS IMIPENEM; E 1010; IMIPENEM; LENAPENEM; MEROPENEM; OFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL PNEUMONIA; ENTEROBACTERIACEAE; GRAM NEGATIVE INFECTION; HAEMOPHILUS INFLUENZAE; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STREPTOCOCCUS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031039542     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.2.298     Document Type: Article

References (27)

1. Büscher, K. H., W. Cullmann, W. Dick, and W. Opferkuch. 1987. Imipenem resistance in Pseudomonas aeruginosa resulting from diminished expression of an outer membrane protein. Antimicrob. Agents Chemother. 31:703-708.
2. Bush, K., G. A. Jacoby, and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:1211-1233.
3. Jogensen, J. H., J. S. Redding, L. A. Maher, and A. W. Howell. 1987. Improved medium for antimicrobial susceptibility testing of Haemophilus influenzae. J. Clin. Microbiol. 25:2105-2113.
4. Katsu, K., K. Kitoh, M. Inoue, and S. Mitsuhashi. 1982. In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin. Antimicrob. Agents Chemother. 22:181-185.
5. Kusube, K., S. Taniguchi, M. Nakamura, N.-A. Watanabe, F. Ohba, and T. Horie. 1995. ER-35786, a new antipseudomonal carbapenem: IV. pharmacokinetics in laboratory animals, abstr. F154, p. 139. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
6. Litchfield, J. T., Jr., and F. Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:99-113.
7. Livermore, D. M. 1992. Interplay of impermeability and chromosomal β-lactamase activity in imipenem-resistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36:2046-2048.
8. Marumo, K., A. Takeda, Y. Nakamura, and K. Nakaya. 1995. Purification and characterization of metallo-β-lactamase from Serratia marcescens. Microbiol. Immunol. 39:27-33.
9. Masuda, N., and S. Ohya. 1992. Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36:1847-1851.
10. Minami, S., A. Yotsuji, M. Inoue, and S. Mitsuhashi. 1980. Induction of β-lactamase by various β-lactam antibiotics in Enterobacter cloacae. Antimicrob. Agents Chemother. 18:382-385.
11. Mitsuhashi, S., and M. Inoue. 1981. Mechanisms of resistance to β-lactam antibiotics, p. 41-56. In S. Mitsuhashi (ed.). Beta-lactam antibiotics. Springer-Verlag, New York, N.Y.
12. Nakagawa, S., T. Hashizume, K. Matsuda, M. Sanada, O. Okamoto, H. Fukatsu, and N. Tanaka. 1993. In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity. Antimicrob. Agents Chemother. 37:2756-2759.
13. Neu, H. C., and P. Labthavikul. 1982. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its β-lactamase stability. Antimicrob. Agents Chemother. 21:180-187.
14. Ohba, F., N.-A. Watanabe, M. Nakamura, and K. Katsu. 1995. ER-35786, a new antipseudomonal carbapenem. III. In vivo antibacterial activity, abstr. F153. p. 139. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
15. Osano, E., Y. Arakawa, R. Wacharotayankun, M. Ohta, T. Hori, H. Ito, F. Yoshimura, and N. Kato. 1994. Molecular characterization of an enterobacterial metallo β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob. Agents Chemother. 38:71-78.
16. Pearson, R. D., R. T. Steigbigel, H. T. Davis, and S. W. Chapman. 1980. Methods for reliable determination of minimal lethal concentrations. Antimicrob. Agents Chemother. 18:699-708.
17. Saino, Y., F. Kobayashi, M. Inoue, and S. Mitsuhashi. 1982. Purification and properties of inducible penicillin β-lactamase isolated from Pseudomonas maltophilia. Antimicrob. Agents Chemother. 22:564-570.
18. Sanders, C. C. 1987. Chromosomal cephalosporinases responsible for multiple resistance to newer β-lactam antibiotics. Amm. Rev. Microbiol. 41:573-593.
19. Sumita, Y., M. Inoue, and M. Mitsuhashi. 1989. In vitro antipseudomonal activity and β-lactamase stability of the new carbapenem SM7338. Eur. J. Clin. Microbiol. Infect. Dis. 8:908-916.
20. Toyosawa, T., S. Miyazaki, A. Tsuji, K. Yamaguchi, and S. Goto. 1993. In vitro and in vivo antibacterial activities of E 1077, a novel parenteral cephalosporin. Antimicrob. Agents Chemother. 37:60-66.
21. Toyosawa, T., K. Hata, J. Ueno, M. Moriyama, and K. Katsu. 1994. Effects of cefclidin on experimental respiratory infection caused by Pseudomonas aeruginosa in immunosuppressed mice. Chemotherapy (Tokyo) 29:1242-1246.
22. Trias, J., J. Dufresne, R. C. Levesque, and H. Nikaido. 1986. Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 33:1201-1206.
23. Trias, J., and H. Nikaido. 1990. Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 34:52-57.
24. Watanabe, N.-A., K. Katsu, M. Moriyama, and K. Kitoh. 1988. In vitro evaluation of E1044. a new cephalosporin with potent anti-pseudomonal activity. Antimicrob. Agents Chemother. 32:693-701.
25. Watanabe, N.-A., R. Hiruma, and K. Katsu. 1992. In vitro evaluation of E1077, new cephalosporin with a broad antibacterial spectrum. Antimicrob. Agents Chemother. 36:589-597.
26. Watanabe, N.-A., and K. Katsu. 1992. Bactericidal activity of cefclidin (E1040) against Pseudomonas aeruginosa under conditions simulating plasma pharmacokinetics: lack of development of chromosomally-mediated resistance to β-lactams. J. Antimicroh. Chemother. 30:475-487.
27. Wise, R., J. H. Andrews, and K. A. Bedford. 1980. Comparison of in vitro activity of GR20263, a novel cephalosporin derivative, with activities of other beta-lactam compounds. Antimicrob. Agents Chemother. 17:884-889.