Ultrastructural localization of IgG and TPO in autoimmune thyrocytes referring to the transcytosis of IgG and the antigen presentation of TPO

Histochemistry and Cell Biology

Volumn 107, Issue 2, 1997, Pages 115-120

  Zimmer, Klaus Peter ^c   Scheumann, Georg F W ^a   Brämswig, Jürgen ^c   Böcker, Werner ^b   Harms, Erik ^c   Schmid, Kurt W ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN G; THYROID PEROXIDASE;

ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; ETIOLOGY; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; PRIORITY JOURNAL;

AUTOANTIGENS; ENDOPLASMIC RETICULUM; GRAVES DISEASE; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; IODIDE PEROXIDASE; THYROID GLAND; THYROIDITIS, AUTOIMMUNE;

EID: 0031039095     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180050095     Document Type: Article

References (40)

1. Alquier C, Ruf J, Athouel-Haon A-M, Carayon P (1989) Immunocylochemical study of localization and traffic of thyroid peroxidase/microsomal antigen. Autoimmunity 3:113-123
2. Bogner U, Schleusener H, Wall JR (1984) Antibody-dependent cell mediated cytotoxicity against human thyroid cells in Hashimoto's thyroiditis but not Graves' disease. J Clin Endocrinol Metab 59:734-738
3. Braciale TJ, Braciale V (1991) Antigen presentation: structural themes and functional variations. Immunol Today 12:124-129
4. Chazenbalk GD, Portolano S, Russo D, Hutchison JS, Rapoport B, McLachlan S (1993) Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ. J Clin Invest 92:62-74
5. Dayan CM, Londei M, Corcoran AE, Grubeck-Loebenstein B, James RFL, Rapoport B, Feldmann M (1991) Autoantigen recognition by thyroid-infiltrating T cells in graves' disease. Proc Natl Acad Sci USA 88:7415-7419
6. Fujiwara H, Forisu M, Sugisaki T, Okano H (1981) Immune complex deposits in thyroid glands of patients with Graves' disease. II. Anti-thyroglobulin and anti-microsomal activities of γ-globulin eluted from thyroid homogenates. Clin Immunol Immunopathol 19:109-117
7. Griffiths G (1993) Fine structure immunocytochemistry. Springer, Heidelberg Berlin New York
8. Heimann P (1966) Ultrastructure of human thyroid. Acta Endocrinol Copenh 53[Suppl 110] 3-102
9. Kalderon AE, Bogaars HA (1977) Immune complex deposits in graves' disease and Hashimoto's thyroiditis. Am J Med 63: 729-734
10. Kartenbeck J, Stuckenbrok H, Helenius A (1989) Endocytosis of simian virus 40 into the endoplasmic reticulum. J Cell Biol 109:2721-2729
11. Khoury EL, Hammond L, Bottazzo GF, Doniach D (1981) Presence of the organ-specific 'microsomal' autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity. Clin Exp Immunol 45:316-328
12. Khoury EL, Bottazzo GF, Roitt IM (1984) The thyroid 'microsomal' antibody revisited. Its paradoxical binding in vivo to the apical surface of the follicular epithelium. J Exp Med 159: 577-591
13. Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayama T, Ohtaki S (1987) Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad Sci USA 84:5555-5559
14. Koch N, Lauer W, Habicht J, Dobberstein B (1987) Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteinerich domain highly homologous to a repetitive sequence of thyroglobulin. EMBO J 6:1677-1683
15. Koffler D, Friedman AH (1964) Localization of immunoglobulins in chronic thyroiditis. Lab Invest 13:239-245
16. Kohno Y, Yamaguchi F, Saito K, Niimi H, Nishikawa T, Hosoya T (1991) Anti-thyroid peroxidase antibodies in sera from healthy subjects and from patients with chronic thyroiditis: differences in the ability to inhibit thyroid peroxidase activities. Clin Exp Immunol 85:459-463
17. Kotani T, Ohtaki S (1987) Characterization of thyroid follicular cell apical plasma membrane peroxidase using monoclonal antibody. Endocrinol Jpn 34:407-413
18. Libert F, Ruel J, Lugdate M, Swillens S, Alexander N, Vassart G, Dinsart C (1987) Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules. EMBO J 6:4193-4196
19. Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G (1989) Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem Biophys Res Commun 165:1250-1255
20. Madara JL (1989) Loosening tight junctions. J Clin Invest 83:1089-1094
21. Malthièry Y, Lissitzky S (1987) Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA. Eur J Biochem 165:491-498
22. Miesenböck G, Rothman JE (1995) The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack. J Cell Biol 129:309-319
23. Mölne J, Nilsson M, Jansson S, Hansson G, Ericson LE (1991) Non-polarized cell surface expression of HLA-A, B, C and HLA-DR antigens in Graves' thyroid follicle cells. Autoimmunity 10:189-199
24. Most J, Wick G (1986) Class II antigens in Hashimoto thyroiditis. II. Expression of HLA-DR on infiltrating mononuclear cells in peripolesis. Clin Immunol Immunopathol 41:175-183
25. Nagayama Y, Rapoport B (1992) The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning. Mol Endocrinol 6:145-156
26. Nagayama Y, Kaufman KD, Seto P, Rapoport B (1989) Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 165:1184-1190
27. Nilsson M, Mölne J, Karlsson FA, Ericson LE (1987) Immunoelectron microscopic studies on the cell surface location of the thyroid microsomal antigen. Mol Cell Endocrinol 53:177-186
28. Nunez J, Pommier J (1982) Formation of thyroid hormones. Vitam Horm 39:175-229
29. Okamoto Y, Hamada N, Fujisawa T, Noh J, Yamakawa J, Ohno M, Ito K, Morii H (1991) Why no simple relationship between thyroid peroxidase activity-inhibiting immunoglobulins and thyroid function in autoimmune thyroid disease? Acta Endocrinol Copenh 124:442-448
30. Paschke R, Bruckner N, Schmeidl R, Pfiester P, Usadel KH (1991) Predominant intraepithelial localization of primed T cells and immunoglobulin-producing lymphocytes in Graves' disease. Acta Endocinrol Copenh 124:630-636
31. Rousset B, Kostrouch Z, Pommier J, Munari-Silem Y (1990) Immunolocalization of functional thyroperoxidase and expression of thyroid cell differentiation. In: Carayon P, Ruf J (eds) Thyroperoxidase and thyroid autoimmunity, vol 207. Colloque INSERM, John Libbey Eurotext, pp 117-125
32. Ruf J, Ferrand M, Durand-Gorde JM, Carayon P (1992) Immunopurification and characterization of thyroid autoantibodies with dual specificity for thyroglobulin and thyroperoxidase. Autoimmunity 11:179-188
33. Sandvig K, Garred O, Prydz, K, Kozlov JV, Hansen SH, Deurs B van (1992) Retrograde transport of endocytosed Shiga toxin to the endoplusmic reticulum. Nature 358:510-512
34. Taurog A (1982) Hormone synthesis: thyroid iodine metabolism. In: Ingbar SH, Braverman LE (eds) Werner's the thyroid. Lippincott, Philadelphia, pp 53-97
35. Theuer CP, Buchner J, Fitzgerald D, Pastan I (1993) The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion. Proc Natl Acad Sci USA 90:7774-7778
36. Tice LW, Wollman SH (1974) Ultrastruetural localization of peroxidase on pseudopods and other structures of the typical thyroid epithelial cell. Endocrinology 94:1555-1567
37. Werner SC, Wegelius O, Fierer JA, Hsu KC (1972) Immunoglobulins (E, M, G) and complement in the connective tissues of the thyroid in Graves' disease. N Engl J Med 287:421-425
38. Zakarija M, McKenzie JM (1987) The spectrum and significance of autoantibodies reacting with the thyrotropin receptor. Endocrinol Metab Clin North Am 16:343-363
39. Zimmer KP, Hengst K, Carayon P, Brämswig J, Harms E (1992) Different concentrations of thyroid peroxidase and thyroglobulin in the nuclear envelope and the endoplasmic reticulum throughout the cytoplasm. Eur J Cell Biol 57:12-20
40. Zimmer KP, Schmid KW, Böcker W, Scheumann GFW, Dralle H, Brämswig J, Harms E (1996) Transcytosis of IgG from the basolateral to apical membrane of human thyrocytes in autoimmune thyroid disease. Curr Top Pathol (in press)