The influence of track structure on the understanding of relative biological effectiveness for induction of chromosomal exchanges in human lymphocytes

Radiation Research

Volumn 147, Issue 2, 1997, Pages 208-214

  Moiseenko, V V ^a   Edwards, A A ^b   Nikjoo, H ^c   Prestwich, W V ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; DOUBLE STRANDED DNA;

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; DICENTRIC CHROMOSOME; DNA STRAND BREAKAGE; GAMMA IRRADIATION; HUMAN; HUMAN CELL; LINEAR ENERGY TRANSFER; LYMPHOCYTE; MODEL; PRIORITY JOURNAL; PROTON RADIATION; RADIATION RESPONSE; RELATIVE BIOLOGIC EFFECTIVENESS; X IRRADIATION;

ALPHA PARTICLES; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; COBALT RADIOISOTOPES; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; HELIUM; HUMANS; LINEAR ENERGY TRANSFER; LYMPHOCYTES; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PROTONS; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 0031038613     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579422     Document Type: Article

References (34)

1. D. C. Lloyd and A. A. Edwards, Chromosome aberrations in human lymphocytes: Effect of radiation quality, dose, and dose rate. In Radiation-Induced Chromosome Damage in Man. pp. 23-49. Alan R. Liss, New York, 1983.
2. ICRP, 1990 Recommendations of the International Commission on Radiological Protection. Publication 60, Annals of the ICRP 21, Pergamon Press, New York, 1991.
3. J. R. K. Savage, Update on target theory as applied to chromosomal aberrations. Environ. Mol. Mutagen. 22, 198-207 (1993).
4. G. J. Neary, Chromosome aberrations and the theory of RBE 1. General considerations. Int. J. Radiat Biol. 9, 477-502 (1965).
5. A. M. Kellerer and H. H. Rossi, A generalized formulation of dual radiation action. Radiat. Res. 75, 471-488 (1978).
6. R. K. Sachs, B. L. Yates, J. Tarver and W. F. Morgan, Modelling the formation of polycentric chromosome aberrations. Int. J. Radiat. Biol. 62, 449-460 (1992).
7. D. Harder, The pairwise lesion interaction model. In Quantitative Mathematical Models in Radiation Biology (J. Kiefer, Ed.), pp. 159-170. Springer-Verlag, Berlin and Heidelberg, 1988.
8. R. K. Sachs and D. J. Brenner, Effect of LET on chromosomal aberration yields. I. Do long-lived, exchange-prone double strand breaks play a role? Int. J. Radiat. Biol. 64, 677-688 (1993).
9. D. E. Lea, Actions of Radiations on Living Cells. 2nd ed., pp. 249-252. Cambridge University Press, Cambridge, 1956.
10. T. J. Jenner, C. M. DeLara, P. O'Neill and D. L. Stevens, Induction and rejoining of double strand breaks in V79-4 mammalian cells following gamma and alpha irradiation. Int. J. Radiat. Biol. 64, 265-273 (1993).
11. K. M. Prise, Use of radiation quality as a probe for DNA lesion complexity. Int. J. Radiat. Biol. 65, 43-48 (1994).
12. M. Belli, F. Cera, R. Cherubini, F. fanzini, G. Moschini, O. Sapora, G. Simone, M. A. Tabocchini and P. Tiveron, DNA double-strand breaks induced by low energy protons in V79 cells. Int. J. Radiat. Biol. 65, 529-536 (1994).
13. B. Rydberg, M. Löbrich and P. K. Cooper, DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiat. Res, 139, 133-141 (1994).
14. G. Kampf and K, Eichorn, DNA strand breakage by different radiation qualities and relations to cell killing: Further results after the influence of alpha particles and carbon ions. Stud. Biophys, 93, 17-26 (1983).
15. D. E. Charlton, H. Nikjoo and J. L. Humm, Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles. Int. J. Radiat. Biol. 56, 1-19 (1989).
16. H. Nikjoo, D. E. Charlton and D. T. Goodhead, Monte Carlo track structure studies of energy deposition and calculation of initial DSB and RBE. Adv. Space Res. 14, (10)161-(10)181 (1994).
17. D. E. Charlton, D. T. Goodhead, W. E. Wilson and H. G. Paretzke, The deposition of energy in small cylindrical targets by high LET radiations. Radiat. Prot. Dosim. 13, 123-125 (1985).
18. H. Nikjoo, D. T. Goodhead, D. E. Charlton and H. G. Paretzke, Energy deposition in small cylindrical targets by monoenergetic electrons. Int. J. Radiat. Biol. 60, 739-756 (1991).
19. D. J. Brenner and J. F. Ward, Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int. J. Radiat. Biol. 61, 737-748 (1992).
20. D. T. Goodhead, Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol. 65, 7-17 (1994).
21. B. Rydberg, W. R. Holley and A. Chatterjee, Regionally multiply damaged sites: theoretical and experimental evidence. In Radiation Damage in DNA: Structure/Function Relationships at Early Times (A. F. Fuciarelli and J. D. Zimbrick, Eds.), pp. 55-64. Battelle Press, Columbus, OH, 1994.
22. A. Chatterjee, J. B. Schmidt and W. R. Holley, Monte Carlo approach in assessing damage in higher order structures of DNA. In Computational Approaches in Molecular Biology (M. N. Varma and A. Chatterjee, Eds.), pp. 225-241. Plenum Press, New York, 1994.
23. A. A. Edwards, V. V. Moiseenko and H. Nikjoo, On the mechanism of the formation of chromosomal aberrations by ionizing radiation. Radiat. Environ. Biophys. 35, 25-30 (1995).
24. D. C. Lloyd, A. A. Edwards and J. S. Prosser, Chromosome aberrations induced in human lymphocytes by in vitro acute x and gamma radiation. Radiat. Prot. Dosim. 15, 83-88 (1986).
25. A. A. Edwards, D. C. Lloyd, J. S. Prosser, P. Finnon and J. E. Moquet, Chromosome aberrations induced in human lymphocytes by 8.7 MeV protons and 23.5 MeV helium-3 ions. Int. J. Radiat. Biol. 50, 137-145 (1986).
26. D. G. Papworth, Curve fitting by maximum likelihood. Appendix to paper by J. R. K. Savage, Radiation induced chromosomal aberrations in the plant tradescentia: dose-response curves. Radiat. Bot. 15, 127-131 (1975).
27. IAEA, Biological Dosimetry: Chromosomal Aberration Analysis for Dose Assessment. Technical Report Series No. 260, International Atomic Energy Agency, Vienna, 1986.
28. S. Uehara, H. Nikjoo and D. T. Goodhead, Cross-sections for water vapour for the Monte Carlo electron track structure code from 10 eV to the MeV region. Phys. Med. Biol. 38, 1841-1858 (1993).
29. W. E. Wilson, J. H. Miller and H. Nikjoo, PITS: A code system for positive ion track simulation. In Computational Approaches in Molecular Biology (M. N. Varma and A. Chatterjee, Eds.). Plenum Press, New York, 1994.
30. A. M. Kellerer and H. H. Rossi, The theory of dual radiation action. Curr. Top. Radiat. Res. 8, 85-158 (1974).
31. T. Straume and J. N. Lucas, A comparison of the yields of translocations and dicentrics measured using fluorescence in situ hybridization. Int. J. Radiat. Biol. 64, 185-187 (1993).
32. H. Nikjoo and D. E. Charlton, Calculation of range and distributions of damage to DNA by high- and low-LET radiations. In Radiation Damage in DNA: Structure/Function Relationships at Early Times (A. F. Fuciarelli and J. D. Zimbrick, Eds.), pp. 29-41. Battelle Press, Columbus, OH, 1994.
33. K. H. Chadwick and H. P. Leenhouts, The Molecular Theory of Radiation Biology. Springer-Verlag. Berlin, Heidelberg and New York, 1981.
34. P. J. Simpson and J. R. K. Savage, Identification of x-ray induced complex chromosome exchanges using fluorescence in situ hybridisation: a comparison at two doses. Int. J. Radiat. Biol. 66, 629-632 (1994).