Strategies for optimizing MRI techniques aimed at monitoring disease activity in multiple sclerosis treatment trials

Journal of Neurology

Volumn 244, Issue 2, 1997, Pages 76-84

  Barkhof, Frederik ^a   Filippi, Massimo ^b   Miller, David H ^c   Tofts, Paul ^c   Kappos, Ludwig ^d   Thompson, Alan J ^c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Magnetic resonance imaging; Multiple sclerosis; Trial design

Indexed keywords

GADOLINIUM;

ARTICLE; CONTRAST ENHANCEMENT; DISEASE ACTIVITY; ERROR; HUMAN; MEASUREMENT; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVER VARIATION; PRIORITY JOURNAL;

EID: 0031037995     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004150050053     Document Type: Article

References (54)

1. Noseworthy JH, Vandervoort MK, Wong CJ, et al (1990) Interrater variability with the Expanded Disability Status Scale (EDSS) and Functional Systems (FS) in a multiple sclerosis trial. Neurology 110:971-975
2. Whitaker NJ, McFarland HF, Rudge P, Reingold SC (1995) Outcome assessment in multiple sclerosis clinical trials: a critical analysis. Multiple sclerosis 1:37-47
3. Burkhof F, Scheltens P, Frequin STFM, Nauta JJP, Tas MW, Valk J, Hommes OR (1992) Relapsing remitting multiple sclerosis: sequential enhanced MR imaging vs clinical findings in determining disease activity. AJR 159:1041-1047
4. Koopmans RA, Li DKB, Grochowski E, Cutler PJ, Paty DW (1989) Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol 25:74-81
5. Miller DH, Barkhof F, Albert PS, et al (1996) Guidelines for the use of magnetic resonance techniques to monitor the treatment of multiple sclerosis. Ann Neurol 39:6-16
6. McFarland HF, Frank JA, Albert PS, et al (1992) Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 32:758-766
7. McDonald WI, Miller DP, Thompson AJ (1994) Are magnetic resonance findings predictive of clinical outcome in therapeutic trials in multiple sclerosis? The dilemma of interferon-beta. Ann Neurol 36:14-18
8. Barkhof F, Filippi M (1995) Can MRI be a predictor of long-term clinical out-come for MS? Int MS J 2:4-9
9. Paty DW, Li DKB (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicentre, randomized, double-blind, placebo-controlled trial. Neurology 43:662-667
10. IFNB Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicentre, randomized, double-blind, placebo-controlled trial. Neurology 54:655-661
11. Katz J, Taubenberger J, Raine C, et al (1990) Gadolinium-enhancing lesion on magnetic resonance imaging: neuropathological findings. Ann Neurol 28:243
12. Grossman RI, Gonzalez-Scrarano F, Atlas SW, et al. (1986) Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 161:721-725
13. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M (1991) Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three at autopsy. Radiology 180:467-474
14. Miller DH, Barkhof F, Nauta JJP (1993) Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain 116:1077-1094
15. Kermode AG, Tofts PS, Thompson AJ, et al (1990) Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement. Neurology 40: 229-235
16. Tofts PS, Kermode AG (1991) Measurements of the blood-brain barrier permeability and leakage space using dynamic MR imaging. I. Fundamental concepts. Magn Reson Med 17:357-367
17. Filippi M, Campi A, Martinelli V, Colombo B, Yousry T, Canal N, Scotti G, Comi GC (1995) Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 59:540-544
18. Filippi M, Yousry T, Campi A, et al (1996) Comparison of triple dose versus standard dose of gadolinium-DTPA in the detection of MRI enhancing lesions in patients with MS. Neurology 46:379-384
19. Barkhof F, Valk J, Hommes OR, Scheltens P, Nauta JJP (1992) Gd-DTPA enhancement of multiple sclerosis lesions on long TR spin-echo images at 0.6 T. AJNR 13:1257-1259
20. Haustein J, Laniado M, Niendorf HP, et al (1993) Triple-dose versus standard dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology 186:855-860
21. Yuh WTC, Engelken JD, Muhonen MG, Mayr NA, Fisher DJ, Ehrhardt JC (1992) Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. AJNR 13: 335-345
22. Tevesz T, Kidd D, Barnard RO, McDonald WI (1994) A comparison of the pathology of primary and secondary progressive multiple sclerosis. Brain 117:759-765
23. Wolff SD, Balaban RS (1994) Magnetization transfer imaging: practical aspects and clinical applications. Radiology 192:593-599
24. Wolff SD, Balaban RS (1989) Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Res Med 10:135-144
25. Dixon WT, Engels H, Castillo M, Sardashti M (1990) Incidental magnetization transfer contrast in standard multi-slice imaging. Magn Reson Imaging 8: 417-422
26. Mehta RC, Pike GB, Enzmann DR (1995) Improved detection of enhancing and non-enhancing lesions of multiple sclerosis with magnetization transfer. AJNR 16:1771-1778
27. Goodkin DE, Vander Burg-Medendorp S, Ross J (1993) The effect of repositioning error on serial magnetic resonance imaging scans. Arch Neurol 50: 569-570
28. Goodkin DE, Ross JE, Vander Burg-Medendorp S, Konecsni J, Rudick RA (1992) Magnetic resonance imaging lesion enlargement in multiple sclerosis. Disease related activity, chance occurrence, or measurement artifact? Arch Neurol 49:261-263
29. Filippi M, Horsfield MA, Baratti C, Reganati P, Bressi S, Martinelli V, Miller DH, Comi G (1995) Intra- and inter-rater agreement of brain MRI lesion volume measurements in multiple sclerosis: a comparison of techniques (abstract). Neurology 45[Suppl 4]:A399
30. Walderveen MAA van, Barkhof F, Hommes OR, Polman CH, Tobi H, Frequin STFM, Valk J (1995) Correlating MR imaging and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short TR/ short TE ("T1-weighted") spin-echo images. Neurology 45:1684-1690
31. Smith ME, Stone LA, Albert PS, et al (1993) Clinical worsening in MS is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions. Ann Neurol 33:480-489
32. Stone LA, Albert PS, Smith ME, et al (1995) Changes in the amount of diseases white matter over time in patients with relapsing-remitting sclerosis. Neurology 45:1808-1814
33. McDonald WI, Miller DH, Barnes D (1992) The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol 18:319-334
34. Truyen L, Waesherghe JHTM van, Waldervaan MAA van, et al (in press) Accumulation of hypointense lesions ("black holes") on T1 spin echo MRI correlates with disease progression in multiple sclerosis. Neurology
35. Gass A, Barker HJ, Kidd D, et al (1994) Correlation of magnetic transfer ratio with clinical disability in multiple sclerosis. Ann Neurol 36:62-67
36. Arnold DL, Matthews PM, Francis G, Antel J (1990) Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 14:154-159
37. Larsson HBW, Thomson C, Frederiksen J, et al (1992) In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. Magn Reson Imaging 10:7-12
38. Filippi M, Barker GJ, Horsefield MA, et al (1994) Benign and secondary progressive multiple sclerosis: a preliminary quantitative study. J Neurol 241-251
39. Dousset V, Grossman RI, Ramer KN, et al (1992) Experimental allergic encephalomyelitis and mutliple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 182: 483-491
40. Davie CA, Hawkins CP, Barker GJ, et al (1994) Serial proton magnetic resonance spectroscopy in multiple sclerosis. Brain 117:49-58
41. Thorpe JW, Halpin SF, MacManus DG, Barker GJ, Kendall BE, Miller DH (1994) A comparison between fast and conventional spin-echo in the detection of multiple sclerosis lesions. Neuroradiology 36:388-392
42. Thorpe JW, Barker GJ, MacManus DG, Moseley IF, Tofts PS, Miller DH (1994) Detection of multiple sclerosis by magnetic resonance imaging. Lancet 344:1235
43. Hajnal JV, Bryant DJ, Kasuhoski L, et al (1992) Use of fluid attenuated inversion recovery (FLAIR) pulse sequence in MRI of the brain. J Comput Assist Tomogr 16:841-844
44. Baratti C, Barkhof F, Hoogenraad F, Valk J (1995) Partially saturated fluid attenuated inversion recovery (FLAIR) sequences in multiple sclerosis: comparison with fully relaxed FLAIR and conventional spin echo. Magn Reson Imaging 13:513-521
45. Rydberg JN, Hammond CA, Grimm RC, et al (1994) Initial clinical experience in MR imaging of the brain with a fast fluid-attenuated inversion-recovery pulse sequences. Radiology 193:173-180
46. Plummer DL (1992) Dispimage a display and analysis tool for medical images. Riv Neuroradiol 5:489-495
47. Grimaud J, Lui M, Thorpe JW, et al (1995) Evaluation of computer assisted quantification of MS lesions in cranial MRI (abstract). J Neurol 242 [Suppl 2]:S119
48. Wicks DAG, Tofts PS, Miller DH, et al (1992) Volume measurements of multiple sclerosis lesions with magnetic resonance images: a preliminary study. Neuroradiology 34:475-479
49. Gonzalez CF, Vinitski S, Lublin F, Knobler R, Shehagiri S (1995) Tissue segmentation and volumetric measurements as a marker of disease activity in MS (abstract). Neurology 45 [Suppl 4]:A232
50. Filippi M, Horsfield MA, Tofts PS, Barkhof AJ, Thompson AJ, Miller DH (1996) Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis. Brain 118:1601-1612
51. Arnold DL, Riess GT, Matthews PM, et al (1994) Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 36:76-82
52. Barbosa S, Blumhardt LD, Roberts N, Lock T, Edwards RHT (1994) Magnetic resonance relaxation time mapping in multiple sclerosis: normal appearing white matter and the "invisible" lesion load. Magn Reson Imaging 12:33-42
53. Kidd D, Thorpe JW, Thompson AJ, et al (1993) Spinal cord MRI using multiarray coils and fast spin-echo. II. Findings in multiple sclerosis. Neurology 43:2632-2637
54. Thorpe JW, Kidd D, Moseley IF, et al (1996) Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 46:373-378