Oxygen-dependent regulation of erythropoietin gene expression in rat hepatocytes

Kidney International

Volumn 51, Issue 2, 1997, Pages 502-506

  Göpfert, Thea ^a   Eckardt, Kai Uwe ^b   Geb, Bernhard ^b   Kurtz, Armin ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HORMONE SYNTHESIS; HYPOXIA; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SENSOR; SIGNAL TRANSDUCTION;

EID: 0031037707     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.70     Document Type: Conference Paper

References (35)

1. ECKARDT K-U, RATCLIFFE PJ, TAN CC, BAUER C, KURTZ A: Age dependent expression of the erythropoietin gene in rat livers and kidneys. J Clin Invest 89:753-760, 1992
2. 125I Epo by the placenta. J Clin Invest 82:154-159, 1988
3. TAN CC, ECKARDT K-U, FIRTH JD, RATCLIFFE PJ: Organ distribution of erythropoietin messenger RNA in normal and uremic rats. Kidney Int 40:69-76, 1991
4. BERU N, MCDONALD J, LACOMBE C, GOLDWASSER E: Expression of erythropoietin gene. Mol Cell Biol 6:2571-2575, 1986
5. BONDURANT MC, KOURY MJ: Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 6:2731-2733, 1986
6. SCHOOLEY JC, MAHLMANN LJ: Erythropoietin in the anephric rat. I. Realtionship between nephrectomy, time of the hypoxic exposure and erythropoietin production. Blood 39:31-38, 1972
7. WANG F, FRIED W: Renal and extrarenal erythropoietin production in male and female rats of various ages. J Lab Clin Med 79:181-186, 1972
8. TAN CC, ECKARDT K-U, FIRTH JD, RATCLIFFE PJ: Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. Am J Physiol 263:F474-F481, 1992
9. BACHMANN S, LEHIR M, ECKARDT K-U: Colocalization of erythropoietin mRNA and ecto-5′-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. J Histochem Cytochem 41:335-341, 1993
10. ECKARDT K-U, PUGH W, RATCLIFFE PJ, KURTZ A: Oxygen-dependent modulation of the erythropoietin mRNA in rat hepatocytes in vitro. Pflügers Arch 423:356-364, 1993
11. MAXWELL PH, FERGUSON DJ, OSMOND MK, PUGH CW, HERYET A, DOE BG, JOHNSON MH, RATCLIFFE PJ: Expression of a homologously recombined erythropoietin-SV40 T antigen fusion gene in mouse liver: Evidence for erythropoietin production by Ito cells. Blood 84:1823-1830, 1994
12. MASUDA S, OKANO M, YAMAGISKI K, NAGO M, UEDA M, SASAKI R: A novel site of erythropoietin production. Oxygen-dependent production cultured rat astrocytes. J Biol Chem 269:19488-19493, 1994
13. GOLDBERG MA, GLASS GA, CUNNINGHAM JM, BUNN HF: The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA 84:7972-7976, 1987
14. GOLDBERG MA, GAUT CC, BUNN HF: Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 77:271-277, 1991
15. GOLDBERG MA, DUNNING SP, BUNN HF: Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 242:1412-1415, 1988
16. GLHADLF JM, FBFRT JD, FIRTH JD, RATCLIFFE PJ: Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol 268:C1362-C1368, 1995
17. GÖRLACH A, FANDREY J, HOLTERMANN G, ACKER H: Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid culture. FEBS Lett 348:216-218, 1994
18. FANDREY J, FREDE S, JELKMANN W: Role of hydrogen peroxide in hypoxia-induced erythropoietin production. J Biochem 303:507-510, 1994
19. HAGIWARA M, PINCUS SM, CHEN I-L, BECKMAN BS, FISHER JW: Effects of dibutyryl adenosine 3′,5′-cyclic monophosphate on erythropoietin production in human renal carcinoma cell cultures. Blood 66:714-717, 1985
20. JELKMANN W: Erythropoietin: Structure, control of production, and function. Physiol Rev 72:449-489, 1992
21. KURTZ A, JELKMANN W, PFUHL, A, MALMSIKÖM K, BAUER C: Erythropoietin production by fetal mouse livr cells in response to hypoxia and adenylate cyclase stimulation. Endocrinology 118:567-572, 1986
22. SHERWOOD JB: The chemistry and physiology of erythropoietin. Vitam Horm 41:161-211, 1984
23. UFNO M, SFFERYNSKA I, BECKMAN B, BROOKINS J: Enhanced erythropoietin secretion in hepatoblastoma cells in response to hypoxia. Am J Physiol 257:C743-C749, 1989
24. BERU N, SMITH D, GOLDWASSER E: Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein. (abstract) J Biol Chem 265:14100, 1990
25. SEMENZA GL, NEJFEL MK, CHI SM, ANTONARAKIS SE: Hypoxia-inducible factors hind to an enhancer element 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 88:5680-5684, 1991
26. SHOEMAKER CB, MITSOCK LD: Murine erythropoietin gene: Cloning, expression and human gene homology. (abstract) Moll Cell Biol 6:849, 1986
27. BECK J, RAMIREZ S, WEINMANN R, CARO J: Enhancer clement at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. (abstract) J Biol Chem 266:15563, 1991
28. BLANCHARD KL, ACQUAVIVA AM, GALSON DL, BUNN HF: Hypoxic induction of the human erythropoietin gene: Cooperation between the promotor and enhancer, each of which contains steroid receptor response elements, (abstract) Mol Cell Biol 12:5373, 1992
29. PUGH CW, TAN CC, JONES RW, RATCLIFFE. PJ: Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse crythropoietin gene. Proc Natl Acad Sci USA 88:10553-10557, 1991
30. SEMENZA GL, WANG GL: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447-5454, 1992
31. WANG G, SEMENZA GL: Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237, 1995
32. ECKARDT K-U, RING A, MAIER M, GESS B, FABBRO D, KURTZ A: Hypoxia-induced accumulation of erythropoietin mRNA in isolated hepatocytes is inhibited by protein kinase C. Pflügers Arch 426:21-30, 1994
33. GÖPFERT T, GEB B, ECKARDT K-U, KURIZ A: Hypoxia signaling in the control of erythropoietin gene expression in rat hepatocytes. J Cell Physiol (in press)
34. GESS B, SANDNER P, KURTZ. A: Differential effects of kinase inhibitors on erythropoietin and vascular endothelial growth factor gene expression in rat hepatocytes. Pflügers Arch 432:426-432, 1996
35. GÖPFERT T, GEB B, ECKARDT K-U, KURTZ A: Cobalt exerts opposite effects on erythropoietin gene expression in rat hepatocytes in vivo and in vitro. Am J Physiol 269:R995-R1001, 1995