Antagonist inhibition curves and the measurement of dissociation constants

British Journal of Pharmacology

Volumn 120, Issue 1, 1997, Pages 13-18

  Barlow, R B ^a,b   Bond, Susan M ^a   Bream, Elizabeth ^a   Macfarlane, Lisa ^a   McQueen, D S ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Ash Lea Cottage   (United Kingdom)

Author keywords

Antagonist dissociation constants; Competitive antagonists; Degree of agonist stimulation; Dose ratios; Hill coefficient; IC50; Inhibition curves; K(D); Logistic slope factor; pA2

Indexed keywords

CARBACHOL; MUSCARINIC AGENT;

AGONIST; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ANTAGONISM; GUINEA PIG; ILEUM; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BINDING, COMPETITIVE; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; ILEUM; KINETICS; MALE; MODELS, BIOLOGICAL; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RECEPTORS, MUSCARINIC;

EID: 0031037449     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700865     Document Type: Article

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