Comparison of in vitro carnitine and glycine conjugation with branched- side chain and cyclic side chain carboxylic acids in rats

Drug Metabolism and Disposition

Volumn 25, Issue 2, 1997, Pages 149-153

  Kanazu, Takushi ^b   Yamaguchi, Toshiro ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; CARNITINE; CARNITINE ACETYLTRANSFERASE; GLYCINE; GLYCINE AMIDINOTRANSFERASE;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONJUGATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; KIDNEY SLICE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZOATES; BENZOIC ACID; BUTYRIC ACIDS; CARBOXYLIC ACIDS; CARNITINE; CELLS, CULTURED; CYCLOPROPANES; GLYCINE; KIDNEY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0031037258     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. G. Levy: Pharmacokinetics of salicylate elimination in man. J. Pharm. Sci. 54, 959-967 (1965).
2. J. W. Bridges, M. R. French, R. L. Smith, and R. T. Williams: The fate of benzoic acid in various species. Biochem. J. 118, 47-51 (1970).
3. R. T. Williams: "Detoxication Mechanisms" 2nd ed., pp. 348-367. Chapman & Hall, London, England, 1959.
4. K. Bartlett and D. Gompertz: The specificity of glycine-N-acylase and acylglycine excretion in the organic acidaemias. Biochem. Med. 10, 15-23 (1974).
5. H. S. A. Sherratt: Hypoglycin, the famous toxin of the unripe Jamaican ackee fruit. Trends Pharmacol. Sci. 7, 186-191 (1986).
6. J. Caldwell, J. R. Moffatt, and R. L. Smith: Post-mortem survival of hippuric acid formation in rat and human cadaver tissue samples. Xenobiotica 6, 275-280 (1976).
7. J. Bremer: Carnitine-metabolism and functions. J. Physiol. Rev. 63, 1420-1480 (1983).
8. L. L. Bieber, R. Emaus, K. Valkener, and S. Farrell: Possible functions of short-chain carnitine acyltransferases. Fed. Proc. 41, 2858-2862 (1982).
9. E. Binderup, W. O. Godtfredsen, and J. Roholt: Orally active cephaloglycin esters. J. Antibiotics 24, 767-773 (1971).
10. S. Vickers, C. A. Duncan, S. D. White, G. O. Breault, R. B. Royds, P. J. deSchepper, and K. F. Tempero: Evaluation of succinimidoethyl and pyvaloyloxyethyl esters as progenitors of methyldopa in man, rhesus monkey, dog, and rat. Drug Metab. Dispos. 6, 640-646 (1978).
11. S. Vickers, C. A. H. Duncan, S. D. White, and H. G. Ramjit: Carnitine and glucuronic acid conjugates of pivalic acid. Xenobiotica 15, 453-458 (1985).
12. 14C)S-1108 in rat and dogs. Antimicrob. Agents Chemother. 39, 1445-1453 (1995)
13. K. Totsuka, K. Shimizu, M. Konishi, and S. Yamamoto: Metabolism of S-1108, a new oral cephem antibiotic and metabolic profiles of its metabolites in humans. Antimicrob. Agents Chemother. 36, 757-761 (1992).
14. G. B. Quistad, L. E. Staiger, and D. A. Schooley: Enviromental degradation of the miticide cycloprate (Hexadecyl cyclopropanecarboxylate). 1. Rat metabolism. J. Agric. Food Chem. 26, 60-66 (1978).
15. G. B. Quistad, L. E. Staiger, and D. A. Schooley: Enviromental degradation of the miticide cycloprate (Hexadecyl cyclopropanecarboxylate). 4. Beagle dog metabolism. J. Agric. Food Chem. 26, 76-80 (1978).
16. G. B. Quistad, L. E. Staiger, and D. A. Schooley: Enviromental degradation of the miticide cycloprate (Hexadecyl cyclopropanecarboxylate). 3. Bovine metabolism. J. Agric. Food Chem. 26, 71-75 (1978).
17. D. S. Millington, T. P. Bohman, C. R. Roe, A. L. Yergey, and D. J. Liberate: Valproylcarnitine: a novel drug metabolite identified by fast bombardment and thermospray liquid chromatography-mass spectrometry. Clin. Chimica Acta 145, 69-76 (1985).
18. G. B. Quistad, L. E. Staiger, and D. A. Schooley: The role of carnitine in the conjugation of acidic xenobiotics. Drug Metab. Dispos. 14, 521-525 (1986).
19. R. C. Peffer, D. J. Abraham, M. A. Zemaitis, L. K. Wong, and J. D. Alvin: 3,4-Dichlorobenzyloxyacetic acid is extensively metabolized to a taurine conjugate in rats. Drug Metab. Dispos. 15, 305-311 (1987).
20. T. S. Emudianughe, J. Caldwell, and R. L. Smith: Amino acid conjugation responses to 2-naphthylacetic acid in rodents. Biochem. Soc. Trans. 7, 522-524 (1979).
21. S. J. Kolis, E. J. Postma, T. H. Williams, and G. J. Sasso: Identification of trimoprostil metabolites excreted in rat bile formed by oxidation and taurine conjugation. Drug Metab. Dispos. 14, 465-470 (1986).
22. 14C)sodium pivalate in dogs. Iyakuhin Kenkyu 26, 16-27 (1995).
23. P. Moldeus, J. Hoegberg, and S. Orrenius: Isolation and use of liver cells, in "Methods in Enzymology" (S. Fleischer and L. Packer, eds.),Vol. 52, pp. 60-71. Academic Press, New York, 1978.
24. D. E. Brooks and J. E. A. McIntosh: Turnover of carnitine by rat tissues. Biochem. J. 148, 439-445 (1975).
25. Z. Gregus, T. Fekete, F. Varga, and C. D. Klaassen: Availability of glycine and coenzyme A limits glycine conjugation in vivo. Drug Metab. Dispos. 20, 234-240 (1992).
26. G. Powis, D. C. Melder, and T. J. Wilke: Human and dog, but not rat, isolated hepatocytes have decreased foreign compound-metabolizing activity compared to liver slices. Drug Metab. Dispos. 17, 526-531 (1989).
27. Q. N. Diep, T. Bohmer, and Steinar Skrede: Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. Biochim. Biophys. Acta 1243, 65-70 (1995)
28. Q. N. Diep, O. Brørs, and T. Bøhmer: Formation of pivaloylcarnitine in isolated rat heart cells. Biochim. Biophys. Acta 1259, 161-165 (1995).