Glial alkalinization detected in vivo by 1H-15N heteronuclear multiple-quantum coherence-transfer NMR in severely hyperammonemic rat

Journal of Neurochemistry

Volumn 68, Issue 3, 1997, Pages 1209-1220

  Kanamori, Keiko ^a   Ross, Brian D ^a  

^a HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

Author keywords

Glial alkalinization; Glutamine; NMR; Severe hyperammonemia

Indexed keywords

AMMONIA; AMMONIUM ACETATE; GLUTAMINE;

ALKALINIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN DISEASE; BRAIN LEVEL; DISEASE SEVERITY; GLIA; HYPERAMMONEMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALIA;

EID: 0031036565     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68031209.x     Document Type: Article

References (71)

1. Attwell D., Barbour B., and Szatkowski M. (1993) Nonvesicular release of neurotransmitter. Neuron 11, 401-407.
2. Basile A. S., Jones E. A., and Skolnick P. (1991) The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands. Pharmacol. Rev. 43, 27-71.
3. 31P nuclear magnetic resonance study. J. Neurochem. 53, 102-110.
4. 31P NMR study, in Hepatic Encephalopathy (Butterworth R. F., ed), pp. 189-200. Humana Press, Clifton, New Jersey.
5. 31P NMR spectroscopy. J. Neurochem. 44, 1045-1055.
6. Benjamin A. M., Okamoto K., and Quastel J. H. (1978) Effects of ammonium ions on spontaneous action potentials and on contents of sodium, potassium, ammonium and chloride ions in brain in vitro. J. Neurochem. 30, 131-143.
7. Berger A., Loewenstein A., and Meiboom S. (1959) Nuclear magnetic resonance study of the protolysis and ionization of N-methylacetamide. J. Am. Chem. Soc. 81, 62-67.
8. Berl S., Takagaki G., Clarke D. D., and Waelsch H. (1962) Carbon dioxide fixation in the brain. J. Biol. Chem. 237, 2570-2573.
9. Bleich H. and Wilde J. (1984) Solvent resonance suppression using a sequence of strong pulses. J. Magn. Reson. 56, 154-155.
10. 15N nuclear magnetic resonance investigations on amino acids. Proc. Natl. Acad. Sci. USA 73, 1409-1413.
11. Bosman D. K., Deutz N. E. P., Maas M. A. W., van Eijk H. M. H., Smit J. J. H., de Haan J. G., and Chamuleau R. A. F. M. (1992) Amino acid release from cerebral cortex in experimental acute liver failure, studied by in vivo cerebral cortex microdialysis. J. Neurochem. 59, 591-599.
12. Boyarsky G., Ransom B., Schlue W. R., Davis M. B. E., and Boron W. F. (1993) Intracellular pH regulation in single cultured astrocytes from rat forebrain. Glia 8, 241-248.
13. Branch G. E. K. and Clayton J. O. (1928) The strength of acetamide as an acid. J. Am. Chem. Soc. 50, 1680-1686.
14. - cotransport. Am. J. Physiol. 267, C1633-C1640.
15. Butterworth R. F. (1991) Pathophysiology of hepatic encephalopa thy: the ammonia hypothesis revisited, in Progress in Hepatic Encephalopathy and Metabolic Nitrogen Exchange (Bengtsson F., Jeppsson B., Almdal T., and Vilstrup H., eds), pp. 9-26. CRC Press, Boca Raton, Florida.
16. Butterworth R. F., Girard G., and Giguère J.-F. (1988) Regional differences in the capacity for ammonia removal by brain following portocaval anastomosis. J. Neurochem. 51, 486-490.
17. Chesler M. (1990) The regulation and modulation of pH in the nervous system. Prog. Neurobiol. 34, 401-427.
18. Chesler M. and Kraig R. P. (1987) Intracellular pH of astrocytes increases rapidly with cortical stimulation. Am. J. Physiol. 253, R666-R670.
19. Chesler M. and Kraig R. P. (1989) Intracellular pH transients of mammalian astrocytes. J. Neurosci. 9, 2011-2019.
20. Cooper A. J. L. and Plum F. (1987) Biochemistry and physiology of brain ammonia. Physiol. Rev. 67, 440-519.
21. Deitmer J. W. and Rose C. R. (1996) pH regulation and proton signalling by glial cells. Prog. Neurobiol. 48, 73-103.
22. Diehl P., Fluck E., Günther H., Kosfeld R., and Seelig J. (1992) In vivo MR spectroscopy: potential and limitations, in NMR, Vol. 28: In Vivo Magnetic Resonance Spectroscopy III (Rudin M., ed), pp. 1-190. Springer Verlag, New York.
23. Eigen M. (1964) Proton transfer, acid-base catalysis, and enzymatic hydrolysis. Angew. Chem. (Int. Ed. Engl.) 3, 1-72.
24. Erecińska M. and Silver I. A. (1990) Metabolism and role of glutamate in mammalian brain. Prog. Neurobiol. 35, 245-296.
25. Farrow N. A., Kanamori K., Ross B. D., and Parivar F. (1990) An N-15 NMR study of cerebral, hepatic and renal nitrogen metabolism in hyperammonemic rats. Biochem. J. 270, 473-481.
26. Farrow N., Ross B. D., and Richards J. H. (1996) The measurement of pH in vivo in whole body systems, in Encyclopedia of Nuclear Magnetic Resonance, Vol. 6 (Grant D. M. and Harris R. K., eds), pp. 3562-3565. John Wiley and Sons, Ltd., New York.
27. i-containing extracellular and cytoplasmic compartments in brain. J. Neurochem. 66, 2612-2620.
28. 31P nuclear magnetic resonance. J. Neurochem. 52, 741-749.
29. Fitzpatrick S. M., Behar K. L., and Shulman R. G. (1989b) In vivo NMR spectroscopy studies of cerebral metabolism in rats after portal-caval shunting, in Hepatic Encephalopathy (Butterworth R. F., ed), pp. 177-187. Humana Press, Clifton, New Jersey.
30. 2 and extracellular activities of potassium and hydrogen ions in the cat brain during intraarterial infusion of ammonium acetate. Adv. Exp. Med. Biol. 169, 291-296.
31. Hawkins R. A., Miller A. L., Nielsen R. C., and Veech R. L. (1973) The acute action of ammonia on rat brain metabolism in vivo. Biochem. J. 134, 1001-1008.
32. Holmin T. and Siesjö B. K. (1974) The effect of portacaval anastomosis upon the energy state and upon acid-base parameters of the rat brain. J. Neurochem. 22, 403-412.
33. Kanamori K. and Ross B. D. (1997) In vivo nitrogen MRS studies of rat brain metabolism, in Advances in Neurochemistry (Bachelard H., ed). Plenum Publishing, New York (in press).
34. 1H-detected multiple quantum coherence spectroscopy. J. Magn. Reson. 93, 319-328.
35. 15N NMR study of in vivo cerebral glutamine synthesis in hyperammonemic rats. NMR Biomed. 6, 21-26.
36. 15N heteronuclear multiple-quantum-coherence transfer NMR. J. Magn. Reson. B, 107, 107-115.
37. 15N heteronuclear multiple-quantum coherence-transfer NMR. Biochem. J. 311, 681-688.
38. Kanamori K., Ross B. D., Chung J. C., and Kuo E. L. (1996) Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo. J. Neurochem. 67, 1584-1594.
39. Kauppinen R. A. and Williams S. R. (1994) Nuclear magnetic resonance spectroscopy studies of the brain. Prog. Neurobiol. 44, 87-118.
40. Klotz I. M. and Frank B. H. (1965) Deuterium-hydrogen exchange in amide N-H groups. J. Am. Chem. Soc. 87, 2721-2728.
41. Kun E. and Keamey E. B. (1974) Ammonia, in Methods of Enzymatic Analysis (Bergmeyer H. U. and Gewehn K., eds), pp. 1802-1806. Academic Press, New York.
42. Lund P. (1974) L-Glutamine: determination with glutaminase and glutamate dehydrogenase, in Methods of Enzymatic Analysis (Bergmeyer H. U. and Gewehn K., eds), pp. 1719-1722. Academic Press, New York.
43. Mans A. M., DeJoseph M. R., and Hawkins R. A. (1994) Metabolic abnormalities and grade of encephalopathy in acute hepatic failure. J. Neurochem. 63, 1829-1838.
44. Meister A. (1974) Glutamine synthetase of mammals, in The Enzymes, Vol. 10 (Boyer P.D., ed), pp. 699-754. Academic Press, New York.
45. Meister A. (1985) Glutamine synthetase from mammalian tissues, in Methods in Enzymology, Vol. 113 (Colowick S. P. and Kaplan N. O., eds), pp. 185-199. Academic Press, New York.
46. Molday R. S. and Kallen R. G. (1971) Substituent effects on amide hydrogen exchange rates in aqueous solution. J. Am. Chem. Soc. 94, 6739-6745.
47. Nagelhus E. A., Lehmann A., and Ottersen O. P. (1996) Neuronal and glial handling of glutamate and glutamine during hypoosmotic stress: a biochemical and quantitative immunocytochemical analysis using the rat cerebellum as a model. Neuroscience 72, 743-755.
48. Norenberg M. D. (1995) Hepatic encephalopathy, in Neuroglia (Kettenmann H. and Ransom B. R., eds), pp. 950-963. Oxford University Press, New York.
49. Norenberg M. D. and Martinez-Hernandez A. (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161, 303-310.
50. Ottersen O. P., Zhang N., and Walberg F. (1992) Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum. Neuroscience 46, 519-534.
51. Pappas C. A. and Ransom B. R. (1994) Depolarization-induced alkalinization (DIA) in rat hippocampal astrocytes. J. Neurophysiol. 72, 2816-2826.
52. Pelligrino D. and Siesjö B. K. (1981) Regulation of extra- and intracellular pH in the brain in severe hypoglycemia. J. Cereb. Blood Flow Metab. 1, 85-96.
53. Perrin C. L. (1989) Proton exchange in amides: surprises from simple systems. Acc. Chem. Res. 22, 268-275.
54. Petroff O. A. C. and Prichard J. W. (1983) Cerebral pH by NMR. Lancet ii, 105-106.
55. 2+ ion concentration, and ionic strength. J. Biol. Chem. 244, 3330-3342.
56. Posner J. B. and Plum F. (1960) The toxic effects of carbon dioxide and acetazolamide in hepatic encephalopathy. J. Clin. Invest. 39, 1246-1258.
57. Rao V. L. R., Audet R. M., and Butterworth R. F. (1995) Selective alterations of extracellular brain amino acids in relation to function in experimental portal-systemic encephalopathy: results of an in vivo microdialysis study. J. Neurochem. 65, 1221-1228.
58. Schenker S., McCandless D. W., Brophy E., and Lewis M. S. (1967) Studies on the intracerebral toxicity of ammonia. J. Clin. Invest. 46, 838-848.
59. - exchange. J. Physiol. (Lond.) 475.1, 59-67.
60. Siesjö B. K. (1985) Acid-base homeostasis in the brain; physiology, chemistry and neurochemical pathology. Prog. Brain Res. 63, 121-154.
61. Somjen G. G., Aitken P. G., Czéh G. L., Herreras O., Jing J., and Young J. N. (1992) Mechanisms of spreading depression: a review of recent findings and a hypothesis. Can. J. Physiol. Pharmacol. 70, S248-S254.
62. Somlyo A. P., Urbanics R., Vadasz G., Kovach A. G. B., and Somlyo A. V. (1985) Mitochondrial calcium and cellular electrolytes in brain cortex frozen in situ: electron probe analysis. Biochem. Biophys. Res. Commun. 132, 1071-1078.
63. Sugimoto H., Koehler R. C., Wilson D. A., Brusilow S. W., and Traystman R. J. (1994) Hyperammonemia causes increased extracellular potassium activity dependent on glutamine synthesis. FASEB J. 8, A30.
64. 31P NMR spectroscopy. Brain Res. 641, 328-332.
65. Swain M. S., Blei A. T., Butterworth R. F., and Kraig R. P. (1991) Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats. Am. J. Physiol. 261, R1491-R1496.
66. Szerb J. C. and Butterworth R. F. (1992) Effect of ammonium ions on synaptic transmission in the mammalian central nervous system. Prog. Neurobiol. 39, 135-153.
67. Takahashi H., Koehler R. C., Brusilow S. W., and Traystman R. J. (1991) Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats. Am. J. Physiol. 261, H825-H829.
68. 2 responsivity by glutamine synthesis inhibition in hyperammonemic rats. Circ. Res. 71, 1220-1230.
69. Thomas R. C. (1984) Experimental displacement of intracellular pH and the mechanism of its subsequent recovery. J. Physiol. (Lond.) 354, 3P-22P.
70. Voorhies T. M., Ehrlich M. E., Duffy T. E., Petito C. K., and Plum F. (1983) Acute hyperammonemia in the young primate: physiologic and neuropathologic correlates. Pediatr. Res. 17, 970-975.
71. Willard-Mack C. L., Koehler R. C., Hirata T., Cork L. C, Takahashi H., Traystman R. J., and Brusilow S. W. (1996) Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat. Neuroscience 71, 589-599.