Validation of polyethylene glycol 3350 as a poorly absorbable marker for intestinal perfusion studies

Digestive Diseases and Sciences

Volumn 42, Issue 1, 1997, Pages 1-5

  Schiller, Lawrence R ^a   Santa Ana, Carol A ^a   Porter, Jack ^a   Fordtran, John S ^a  

^a BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

intestinal absorption; perfusion studies; polyethylene glycol

Indexed keywords

MACROGOL;

ADULT; ARTICLE; DIAGNOSIS; DRUG ABSORPTION; GLUCOSE TRANSPORT; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; INTESTINE PERFUSION; INTRAGASTRIC DRUG ADMINISTRATION; NORMAL HUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT; WATER ABSORPTION;

ADULT; BIOLOGICAL TRANSPORT; GLUCOSE; HUMANS; HYPOTONIC SOLUTIONS; INTESTINAL ABSORPTION; INTESTINES; MANNITOL; MIDDLE AGED; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; WATER;

EID: 0031036332     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018863032425     Document Type: Article

References (23)

1. Fordtran JS: Marker perfusion techniques for measuring intestinal absorption in man. Gastroenterology 51:1089-1093, 1966
2. Hyden S: The recovery of polyethylene glycol after passage through the digestive tract. Lantbrukshoegsk Ann 22:411-424, 1956
3. Jacobson ED, Bondy DC, Broitman SA, Fordtran JS: Validity of polyethylene glycol in estimating intestinal water volume. Gastroenterology 44:761-767, 1963
4. Schedl HP: Use of polyethylene glycol and phenol red as unabsorbed indicators for intestinal absorption studies in man. Gut 7:159-163, 1966
5. Maddrey WC, Serebro HA, Marcus H, Iber FL: Recovery, reproducibility, and usefulness of polyethylene glycol, iodine-labelled rose bengal, sulphobromophthalein, and indocyanine green as non-absorbable markers. Gut 8:169-171, 1967
6. Wilkinson R: Polyethylene glycol 4000 as a continuously administered non-absorbable faecal marker for metabolic balance studies in human subjects. Gut 12:654-660, 1971
7. Pappenheimer JR, Reiss KZ: Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J Membr Biol 100:123-136, 1987
8. 14C-polyethylene glycol 4000 in intestinal venous blood: Influence of osmolarity and laxatives, effect on net water flux determination. Arch Pharmacol 321:149-156, 1982
9. Ryan CM, Schmidt J, Lewandrowski K, Compton CC, Rattner DW, Warshaw AL, Tompkins RG: Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. Gastroenterology 104:890-895, 1993
10. Schedl HP, Maughan RJ, Gisolfi CV: Intestinal absorption during rest and exercise: implications for formulating an oral rehydration solution (ORS). Med Sci Sports Exerc 26:267-280, 1994
11. + -coupled nutrient transport. Gastroenterology 109:1391-1396, 1995
12. Davis GR, Santa Ana CA, Morawski SG, Fordtran JS: Development of a lavage solution associated with minimal water and electrolyte absorption or secretion. Gastroenterology 78:991-995, 1980
13. Hyden S: A turbidimetric method for the determination of higher polyethylene glycols in biological materials. Lantbrukshoegsk Ann 22:139-145, 1955
14. Fordtran JS, Rector FS Jr, Ewton MF, Soter N, Kinney J: Permeability characteristics of the human small intestine. J Clin Invest 44:1935-1944, 1965
15. Fordtran JS, Rector FS Jr, Carter NW: The mechanism of sodium absorption in the human small intestine. J Clin Invest 47:884-900, 1968
16. Schiller LR, Santa Ana CA, Morawski SG, Fordtran JS: Mechanism of the antidiarrheal effect of loperamide. Gastroenterology 86:1475-1480, 1984
17. Soergel KH, Hogan WJ: On the suitability of poorly absorbed markers as dilution indicators in the gastrointestinal tract. Gastroenterology 52:1056-1057, 1967
18. Shields R, Harris J, Davies MW: Suitability of polyethylene glycol as a dilution indicator in the human colon. Gastroenterology 54:331-333, 1968
19. Brady CE III, DiPalma JA, Morawski SG, Santa Ana CA, Fordtran JS: Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution. Gastroenterology 90:1914-1918, 1986
20. Schiller LR, Emmett M, Santa Ana CA, Fordtran JS: Osmotic effects of polyethylene glycol, Gastroenterology 94:933-941, 1988
21. Kjellander R, Florin E: Water structure and changes in thermal stability of the system poly(ethylene oxide)-water. J Chem Soc 77:2053-2077, 1981
22. Breen J, Huis D, de Bleijser J, Leyte JC: Solvent dynamics in aqueous PEO-salt solutions studied by nuclear magnetic relaxation. J Chem Soc 84:293-307, 1988
23. Antonsen KP, Hoffman AS: Water structure of PEG solutions by differential scanning calorimetry measurements. In Poly-(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications. J Milton Harris (ed). New York, Plenum Press. 1992, pp 15-28