Comparative effectiveness of three antiprogestins alone and in combination with anordiol in terminating pregnancy in the rat

Contraception

Volumn 55, Issue 1, 1997, Pages 35-40

  Dao, B ^a   Vanage, G ^a   Li, X J ^a   Bardin, C W ^a   Koide, S S ^a  

^a POPULATION COUNCIL   (United States)

Author keywords

anordiol; antiprogestins; mifepristone; onapristone; ORG 31806; pregnancy termination

Indexed keywords

ANORDIOL; ANTIGESTAGEN; MIFEPRISTONE; ONAPRISTONE; ORG 31806; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; FEMALE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PREGNANCY TERMINATION; PROGESTERONE BLOOD LEVEL; RAT;

ABORTIFACIENT AGENTS; ABORTION, DRUG INDUCED; ABORTION, INDUCED; ANIMALS, LABORATORY; BIOLOGY; CLINICAL RESEARCH; COMPARATIVE STUDIES; ENDOCRINE SYSTEM; FAMILY PLANNING; FERTILITY CONTROL, POSTCONCEPTION; HORMONE ANTAGONISTS; HORMONES; PHYSIOLOGY; RESEARCH METHODOLOGY; RESEARCH REPORT; RU-486--PHARMACODYNAMICS; STUDIES;

ABORTION, INDUCED; ADMINISTRATION, ORAL; ANIMALS; COHORT STUDIES; CONTRACEPTIVES, POSTCOITAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; ESTRADIOL; ESTRENES; FEMALE; FURANS; GONANES; HORMONE ANTAGONISTS; MALE; MIFEPRISTONE; NORANDROSTANES; PREGNANCY; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031035548     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(96)00239-9     Document Type: Article

References (15)

1. 1. Philibert D, Deraedt R, Teutsch G. RU 438486: a potent antiglucocorticoid in vivo. VIII International Congress of Pharmacology, Tokyo, Japan, 1981; Abst. No 1463.
2. 2. Elger W, Beier S, Chwalisz K, et al. Studies of the mechanisms of action of progesterone antagonists. J Steroid Biochem 1986;25:835-45.
3. 3. Deckers CHJ, Geelen JAA, Kloosterboor HJ, Van der Heuvel MJ. Endocrine profiles of two novel antiprogestagens: Org 31710 and Org 31806. 72nd Annual Meeting of the Endocrine Society, Atlanta,GA, 1990; Abst. No 136.
4. 4. Chang CC, Wang W-C, Bardin CW. Termination of early pregnancy in the rat, rabbit, and hamster with RU 486 and anordrin. Contraception 1993;47:597-608.
5. 5. Wang WC, Chang CC, Bardin CW. Anordiol is more potent than anordrin for terminating pregnancy when administered with RU 486. Contraception 1993;47: 609-16.
6. 6. Litchfield Jr JT, Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmcol Exp Therapy 1949;96:99-113.
7. 7. Puri CP, Patil RK, D'Souza A, Elger WAG, Pongubala JMR. Pharmacokinetics and pharmacodynamic effects of progesterone antagonist ZK 98299 in female bonnet monkeys. In: Puri CP, Van Look PFA, eds. Hormone antagonists for fertility regulation. Bombay: Indian Society for the Study of Reproduction and Fertility, 1988: 123-40.
8. 8. Brier S, Kaufmann J, Neef G. Antifertile effects of antigestagens (AG) at various stages of pregnancy in rats. Acta Endocrinol 1986;suppl. 274:8-9.
9. 9. Chang CC, Wang W-C, Bardin CW. Postcoital use of anordrin and RU 486 for prevention of implantation in the rat. Contraception 1993;47:413-9.
10. 10. Dao B, Vanage G, Marshall A, Bardin CW, Koide SS. Anti-implantation activity of antiestrogens and mifepristone. Contraception 1996;54:254-8.
11. 11. Lu Y-C, Chatterton JR. Effects of the antiestrogen anordiol on ovulation and endometrial histology in the rat. Adv Contracep 1993;9:257-68.
12. 12. Lynn DE, Chatterton Jr RT, Wentz AC. Inhibition of estrogen biosynthesis in the rat ovary by anordrin. Adv Contracep 1991;7:11-9.
13. 13. Gu ZP, Zhu PY, Qi LM, Shen PJ. Studies on the antifertility effects of anordrin and its analogues. Acta Physiol Sinica 1984;36:611-3.
14. 14. Chatterton Jr RT, Walters NN, Walters PP. Preclinical studies of anordrin: ovulation inhibition, pharmacokinetics, metabolism and toxicology. Proceedings of the Satellite Symposium on Hormone Contraception, International Congress on Endocrinology, Keidanrem Kaikan, Tokyo, 1988;25-32.
15. 15. Vanage, GR, Dao, B, Bardin, CW, Koide, SS. Combination of antiestrogens and mifeprisone for the termination of pregnancy in the rat. Res Comm Pharmacol Toxicol (1997, in press).