The mechanism of excretion of paraquat in rats

Toxicology Letters

Volumn 90, Issue 1, 1997, Pages 1-9

  Chan, B S H ^a   Seale, J P ^b   Duggin, G G ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b University of Sydney   (Australia)

Author keywords

Cation; Paraquat; Renal clearance

Indexed keywords

4 AMINOHIPPURIC ACID; CIMETIDINE; N METHYLNICOTINAMIDE; PARAQUAT; QUININE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; KIDNEY CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOKINETICS;

ANIMALS; ANIONS; BINDING, COMPETITIVE; CATIONS; MALE; PARAQUAT; RATS; RATS, WISTAR;

EID: 0031034277     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(96)03820-9     Document Type: Article

References (20)

1. Naito, H. and Yamashita, M. (1987) Epidemiology of paraquat in Japan and a new safe formulation of paraquat. Hum. Toxicol. 6, 87-88.
2. Sharp, C.W., Ottolenghi, A. and Posner, H.S. (1972) Correlation of paraquat toxicity with tissue concentrations and weight loss of the rat. Toxicol. Appl. Pharmacol. 22, 241-251.
3. Vale, J.A., Meredith, T.J. and Buckley, B.M. (1987) Paraquat poisoning: clinical features and immediate general management. Hum. Toxicol. 6(1), 41-47.
4. Daniel, J.W. and Gage, J.C. (1966) Absorption and excretion of diquat and paraquat in rats. Br. J. Indust. Med. 23, 133-136.
5. Nagata, T., Kono, I., Masaoka, T. and Akahori, F. (1992) Acute toxicological studies on paraquat: pathological findings in beagle dogs following single subcutaneous injections. Vet. Hum. Toxicol. 34(2), 105-112.
6. Lock, E. and Ishmael, J. (1979) The acute toxic effect of paraquat and diquat on the rat kidney. Toxicol. Appl. Pharmacol. 50, 67-76.
7. Vaziri, N.D., Ness, R.L., Fairshiter, R.D., Smith, W.R. and Rosen, S.M. (1979) Nephrotoxicity of paraquat in man. Arch. Intern. Med. 139, 172-174.
8. 1 and MDCK. Res. Comm. Pharmacol. Toxicol. 1(1), 99-112.
9. Hawksworth, G.M., Bennett, P.N. and Davies, D.S. (1981) Kinetics of paraquat elimination in the dog. Toxicol. Appl. Pharmacol. 57, 139-145.
10. Lock, E. (1979) The effect of paraquat and diquat on renal function in the rat. Toxicol. Appl. Pharmacol. 48, 327-336.
11. Webb, D.B. (1983) Nephrotoxicity of paraquat in the sheep and the associated reduction in paraquat secretion. Toxicol. Appl. Pharmacol. 68, 282-289.
12. Davies, D.S., Hawksworth, G.M. and Bennett, P.N. (1977) Paraquat poisoning. Proc. Eur. Soc. Toxicol. 18, 21-26.
13. Purser, D.A. and Rose, M.S. (1979) The toxicity and renal handling of paraquat in Cynomolgus monkeys. Toxicology 15, 31-41.
14. Ferguson, D.M. (1971) Renal handling of paraquat. Br. J. Pharmacol. 42, 635.
15. Houze, P., Baud, F.J., Mouy, R., Bismuth, C., Bourdon, R. and Schermann, J.M. (1990) Toxicokinetics of paraquat in humans. Hum. Exp. Toxicol. 9, 5-12.
16. Ecker, J.L., Gibson, J.E. and Hook, J.B. (1975) In vitro handling of paraquat. Toxicol. Appl. Pharmacol. 34, 170-177.
17. Chatton, J.Y., Odone, M., Besseghir, K. and Roch-Ramel, F. (1990) Renal secretion of 3′-azido-3′-deoxythymidine by the rat. J. Pharmacol. Exp. Ther. 255, 140-144.
18. Lin, J.H., Chen, I.W., Deluna, F.A. and Hichens, M. (1992) Renal handling of alendronate in rats. Drug Metab. Dispos. 20(4), 608-613.
19. Prashad, D.N., Chambers, D. and Beadle, D.J. (1981) Changes in renal function associated with paraquat dichloride toxicity in the domestic fowl. Gen. Pharmacol. 12, 291-293.
20. Pritchard, J.B. and Miller, D.S. (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. 73(4), 765-796.