Investigating the nature of chromatid breaks produced by restriction endonucleases

International Journal of Radiation Biology

Volumn 71, Issue 1, 1997, Pages 21-28

  Harvey, A N ^a   Savage, J R K ^a  

^a Chromosome Damage Group   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; RESTRICTION ENDONUCLEASE;

ANIMAL CELL; ARTICLE; CHO CELL; CHROMATID ABERRATION; CONTROLLED STUDY; IONIZING RADIATION; PRIORITY JOURNAL;

ANIMALS; CHO CELLS; CHROMOSOME BREAKAGE; CRICETINAE; DNA; DNA DAMAGE; DNA REPAIR; DNA RESTRICTION ENZYMES; SISTER CHROMATID EXCHANGE;

EID: 0031034212     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530097144373     Document Type: Article

References (28)

1. BRYANT, P. E., 1984, Enzymatic restriction of mammalian cell DNA using Pvu II and Bam HI: evidence for the double-strand break origin of chromosomal aberrations. International Journal of Radiation Biology, 46, 57-65.
2. BRYANT, P. E. and CHRISTIE, A. F., 1989, Induction of chromosomal aberrations in CHO cells by restriction endonucleases: effects of blunt- and cohesive-ended double-strand breaks in cells treated by the 'pellet' method. Mutation Research, 213, 233-241.
3. CHADWICK, K. H. and LEENHOUTS, H. P., 1981, The Molecular Theory of Radiation Biology, (Berlin: Springer).
4. COSTA, N. D., MASSON, W. K. and THACKER, J., 1993, The effectiveness of restriction endonucleases in cell killing and mutation. Somatic Cell and Molecular Genetics, 19, 479-490.
5. GOODHEAD, D. G., THACKER, J. and COX, R., 1993, Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. International Journal of Radiation Biology, 63, 543-556.
6. 2 and S phase Chinese hamster V79 cells. International Journal of Radiation Biology, 66, 85-98.
7. HARVEY, A. N., COSTA, N. D., THACKER, J. and SAVAGE, J. R. K., Chromosomal aberrations induced by defined DNA double strand breaks: the origin of achromatic lesions. Cancer Research (submitted).
8. HARVEY, A. N. and SAVAGE, J. R. K., 1992, Simple cell-cycle analysis in second division cells. Clinical Cytogenetics Bulletin, 2, 94-96.
9. HEDDLE, J. A., WHISSELL, D. and BODYCOTE, D. J., 1969, Changes in chromosome structure induced by radiations: a test of the two chief hypotheses. Nature, 221, 1158-1160.
10. LEA, O. K., 1946, Actions of Radiations on Living Cells. (Cambridge: Cambridge University Press).
11. NATARAJAN, A. T. and OBE, C., 1984, Molecular mechanisms involved in the production of chromosomal aberrations: III. Restriction endonucleases. Chromosoma, 90, 120-127.
12. NICOLAIDES, N. C. and STOECKERT, C. J., 1990. A simple, efficient method for the separate isolation of RNA and DNA from the same cells. Biotechniques, 8, 154-156.
13. OBE, G., JOHANNES, C. J. and SCHULTE-FROHLINDE, D., 1992, DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation. Mutagenesis, 7, 3-12.
14. PERRY, P. E. and WOLFF, S., 1974, New Giemsa method for the differential staining of sister chromatids. Nature, 251, 156-158.
15. REVELL, S. H., 1955, A new hypothesis for 'chromatid' changes. In Proceedings of a Biology Symposium (1954, Liège), edited by Z. M. Bacq and P. Alexander (London: Butterworths) pp. 84-94.
16. REVELL, S. H., 1959, The accurate estimation of chromatid breakage and its relevance to a new interpretation of chromatid aberrations induced by ionising radiations. Proceedings of the Royal Society (London), Series, B, 150, 563-589.
17. REVELL, S. H., 1974, The breakage-and-reunion theory and the exchange theory for chromosomal aberrations induced by ionising radiations: a short history. Advances in Radiation Biology, 4, 367-416.
18. SAVAGE, J. R. K., 1976, Annotation: Classification and relationships of induced chromosomal structural changes. Journal of Medical Genetics, 13, 103-122.
19. SAVAGE, J. R. K., 1986, The 'Revell Loop'. Clinical Cytogenetics Bulletin, 1, 192-196.
20. SAVAGE, J. R. K., 1989, The production of chromosome structural changes by radiation: an update of Lea (1946), chapter VI. British Journal of Radiology, 62, 507-520.
21. SAVAGE, J. R. K. and HARVEY, A. N., 1991, Revell revisited. Mutation Research, 250, 307-317,
22. SAVAGE, J. R. K. and HARVEY, A. N., 1994, Investigations of aberration origins using BrdU. In Chromosomal Aberrations: Origin and Significance, edited by G. Obe and A. T. Natarajan (Berlin: Springer) pp. 76-91.
23. SAVAGE, J. R. K. and PAPWORTH, D. G., 1991, Excogitations about the quantification of structural chromosomal aberrations. In Advances in Mutagenesis Research, 3, edited by G. Obe (Berlin: Springer), pp. 162-189.
24. SAVAGE, J. R. K., PRESTON, R. J. and NEARY, G.J., 1968, Chromatid Aberrations in Tradescantia bracteala and a further test of Revell's Hypothesis. Mutation Research, 5, 47-56.
25. SAX, K., 1940, An analysis of X-ray-induced chromosomal aberrations in Tradescantia. Genetics, 25, 41-68.
26. SAX, K., 1941, Types and frequencies of chromosomal aberrations induced by X-rays. Cold Spring Harbour Symposium Quantitative Biology, 9, 93-103.
27. WOLFF, S. and PERRY, P., 1974, Differential Giemsa staining of sister-chromatids and the study of sister-chromatid exchanges without autoradiography. Chromosoma, 48, 341-353.
28. WOLFF, S. and BODYCOTE, J. D., 1975, The induction of chromatid deletions in accordance with the breakage-and-reunion hypothesis. Mutation Research, 29, 85-91.