-
1
-
-
0025726126
-
Hexamethylmelamine: Pharmacology and mechanism of action
-
Ames M. M. (1991) Hexamethylmelamine: pharmacology and mechanism of action. Cancer Treat. Rev. 18, 3-14.
-
(1991)
Cancer Treat. Rev.
, vol.18
, pp. 3-14
-
-
Ames, M.M.1
-
2
-
-
0242552969
-
Inhibition of the crocker mouse sarcoma 180 by certain ethyleneimine derivatives and related compounds
-
Buckley S. M., Stock C. C., Crossley M. L. and Rhoads C. P. (1950) Inhibition of the Crocker mouse sarcoma 180 by certain ethyleneimine derivatives and related compounds. Cancer Res. 10, 207-208.
-
(1950)
Cancer Res.
, vol.10
, pp. 207-208
-
-
Buckley, S.M.1
Stock, C.C.2
Crossley, M.L.3
Rhoads, C.P.4
-
3
-
-
0019461054
-
Phase 1 and pharmacological studies of pentamethylmelamine administered by a 24hr intravenous infusion
-
Caspar E. S., Gralla R. J., Garrett R. L., Jones B. R., Woodcock T. M., Gordon C., Kelson D. P. and Young C. W. (1981) Phase 1 and pharmacological studies of pentamethylmelamine administered by a 24hr intravenous infusion. Cancer Res. 41, 1402-1406.
-
(1981)
Cancer Res.
, vol.41
, pp. 1402-1406
-
-
Caspar, E.S.1
Gralla, R.J.2
Garrett, R.L.3
Jones, B.R.4
Woodcock, T.M.5
Gordon, C.6
Kelson, D.P.7
Young, C.W.8
-
4
-
-
0342919331
-
Rationale for the development of stable water soluble analogues of the s-triazine trimelamol
-
Coley H. M., Jarman M. and Judson I. R. (1993) Rationale for the development of stable water soluble analogues of the s-triazine trimelamol. AACR Meeting Proc., Abstract 2223, p. 373.
-
(1993)
AACR Meeting Proc., Abstract
, vol.2223
, pp. 373
-
-
Coley, H.M.1
Jarman, M.2
Judson, I.R.3
-
5
-
-
0028062867
-
Stable analogues of the antitumour agent trimelamol retain in vitro cytotoxicity in drug-sensitive and resistant rodent and human cell lines
-
Coley H. M., Jarman M., Brooks N., Thornton T. J. and Judson I. R. (1994) Stable analogues of the antitumour agent trimelamol retain in vitro cytotoxicity in drug-sensitive and resistant rodent and human cell lines. Eur. J. Cancer 30A, 1827-1836.
-
(1994)
Eur. J. Cancer
, vol.30 A
, pp. 1827-1836
-
-
Coley, H.M.1
Jarman, M.2
Brooks, N.3
Thornton, T.J.4
Judson, I.R.5
-
6
-
-
0029072902
-
The role of the N-(hydroxymethyl)melamines as antitumour agents: Mechanism of action studies
-
Coley H. M., Brooks N., Philips D. H., Hewer A., Jenkins T. C., Jarman M. and Judson I. R. (1995) The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies. Biochem. Pharmac. 49, 1203-1212.
-
(1995)
Biochem. Pharmac.
, vol.49
, pp. 1203-1212
-
-
Coley, H.M.1
Brooks, N.2
Philips, D.H.3
Hewer, A.4
Jenkins, T.C.5
Jarman, M.6
Judson, I.R.7
-
7
-
-
0343790285
-
-
in press
-
Coley H. M., Jarman M., Jones M., Sargent J. M., Kubota T., Lee N. C. J, Goddard P. M., Elgie A. W., Williamson C., Taylor C. G. and Judson I. R. (1996) The activity of N-hydroxymethyl)melamines in fresh human ovarian tumour cells and xenografts (in press).
-
(1996)
The Activity of N-hydroxymethylmelamines in Fresh Human Ovarian Tumour Cells and Xenografts
-
-
Coley, H.M.1
Jarman, M.2
Jones, M.3
Sargent, J.M.4
Kubota, T.5
Lee, N.C.J.6
Goddard, P.M.7
Elgie, A.W.8
Williamson, C.9
Taylor, C.G.10
Judson, I.R.11
-
8
-
-
0342485136
-
-
in press
-
Coley H. M., Jarman M., Brooks N., Goddard P. M., Jones M., Lee N., Kubota T., Halbert G., Owens M. and Harrap K. R. (1996) Preclinical development of the antitumour agent CB7646, bis N-(hydroxymethyl)trimethylinelamine, a stable analogue of trimelamol (in press).
-
(1996)
Preclinical Development of the Antitumour Agent CB7646, Bis N-(hydroxymethyl)trimethylinelamine, a Stable Analogue of Trimelamol
-
-
Coley, H.M.1
Jarman, M.2
Brooks, N.3
Goddard, P.M.4
Jones, M.5
Lee, N.6
Kubota, T.7
Halbert, G.8
Owens, M.9
Harrap, K.R.10
-
9
-
-
0017379974
-
Regression of human lung tumour xenografts induced by water-soluble analogues of hexamethylmelamine
-
Connors T. A., Cumber A. J., Ross W. C. J., Clarke S. A. and Mitchley B. C. V. (1977) Regression of human lung tumour xenografts induced by water-soluble analogues of hexamethylmelamine. Cancel-Treat. Rep. 61, 927-928.
-
(1977)
Cancel-Treat. Rep.
, vol.61
, pp. 927-928
-
-
Connors, T.A.1
Cumber, A.J.2
Ross, W.C.J.3
Clarke, S.A.4
Mitchley, B.C.V.5
-
10
-
-
0017645396
-
Analogues of hexamethylmelamine. The anti-neoplastic activity of derivatives with enhanced water solubility
-
Cumber A. J. and Ross W. C. J. (1977) Analogues of hexamethylmelamine. The anti-neoplastic activity of derivatives with enhanced water solubility. Chem. Biol. Interact. 17, 349-357.
-
(1977)
Chem. Biol. Interact.
, vol.17
, pp. 349-357
-
-
Cumber, A.J.1
Ross, W.C.J.2
-
11
-
-
0018221936
-
Variable oral absorption of hexamethylmelamine in man
-
D'Incalci M., Bolis G., Mangioni C., Morasca L. and Garattini S. (1978) Variable oral absorption of hexamethylmelamine in man. Cancer Treat. Rep. 62, 2117-2119.
-
(1978)
Cancer Treat. Rep.
, vol.62
, pp. 2117-2119
-
-
D'Incalci, M.1
Bolis, G.2
Mangioni, C.3
Morasca, L.4
Garattini, S.5
-
12
-
-
0019819369
-
Influence of ascites on the pharamcokinetics of hexamethylmelamine and N-demethylated metabolites on ovarian cancer patients
-
D'Incalci M., Begglion G., Sessa C. and Mangioni C. (1981) Influence of ascites on the pharamcokinetics of hexamethylmelamine and N-demethylated metabolites on ovarian cancer patients. Eur. J. Cancer 17, 1331-1335.
-
(1981)
Eur. J. Cancer
, vol.17
, pp. 1331-1335
-
-
D'Incalci, M.1
Begglion, G.2
Sessa, C.3
Mangioni, C.4
-
13
-
-
0022870897
-
Pharmacokinetics and metabolism of hexamethylmelamine in mice after i.p. administration
-
Dubois J., Atassi G., Hanocq M. and Abikhali F. (1986) Pharmacokinetics and metabolism of hexamethylmelamine in mice after i.p. administration. Cancer Chemother. Pharmac. 18, 226-230.
-
(1986)
Cancer Chemother. Pharmac.
, vol.18
, pp. 226-230
-
-
Dubois, J.1
Atassi, G.2
Hanocq, M.3
Abikhali, F.4
-
15
-
-
0025642942
-
Development of a patenteral formulation of trimelamol, a synthetic s-triazine carbinolamine-containing cytotoxic agent
-
Gibson M., Denham A. J., Taylor P. T. and Payne N. I. (1990) Development of a patenteral formulation of trimelamol, a synthetic s-triazine carbinolamine-containing cytotoxic agent. J. Parent. Sci. Technol. 44, 306-313.
-
(1990)
J. Parent. Sci. Technol.
, vol.44
, pp. 306-313
-
-
Gibson, M.1
Denham, A.J.2
Taylor, P.T.3
Payne, N.I.4
-
16
-
-
0005386232
-
Cytotoxic agents: III, derivatives of ethyleneimine
-
Hendry J. A., Homer R. F., Rose F. L. and Walpole A. L. (1951) Cytotoxic agents: III, derivatives of ethyleneimine. Br. J. Pharmac. 6, 357-410.
-
(1951)
Br. J. Pharmac.
, vol.6
, pp. 357-410
-
-
Hendry, J.A.1
Homer, R.F.2
Rose, F.L.3
Walpole, A.L.4
-
17
-
-
0026019482
-
Studies on the stability of trimelamol, a carbinolamine-containing antitumour drug
-
Jackson C., Crabb T. A., Gibson M., Russell G., Saunders R. and Thurston D. E. (1991) Studies on the stability of trimelamol, a carbinolamine-containing antitumour drug. J. Pharm. Sci. 80, 245-251.
-
(1991)
J. Pharm. Sci.
, vol.80
, pp. 245-251
-
-
Jackson, C.1
Crabb, T.A.2
Gibson, M.3
Russell, G.4
Saunders, R.5
Thurston, D.E.6
-
18
-
-
0027731249
-
Synthesis and cytotoxicity of potential tumour-inhibitory analogues of trimelamol (2,4,6,-tris[(hydroxymethyl)-methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl
-
Jarman M., Coley H. M., Judson I. R., Thornton T. J., Wilman D. E. V., Abel G. and Rutty C. J. (1993) Synthesis and cytotoxicity of potential tumour-inhibitory analogues of trimelamol (2,4,6,-tris[(hydroxymethyl)-methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl. J. Med. Chem. 36, 4195-4200.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 4195-4200
-
-
Jarman, M.1
Coley, H.M.2
Judson, I.R.3
Thornton, T.J.4
Wilman, D.E.V.5
Abel, G.6
Rutty, C.J.7
-
19
-
-
0022642283
-
6-trimethylmelamine (trimelamol): A cytotoxic s-triazine with reduced neurotoxicity
-
6-trimethylmelamine (trimelamol): a cytotoxic s-triazine with reduced neurotoxicity. Br. J. Cancer 53, 601-606.
-
(1986)
Br. J. Cancer
, vol.53
, pp. 601-606
-
-
Judson, I.R.1
Rutty, C.J.2
Abel, G.3
Graham, M.A.4
-
20
-
-
0024452962
-
6-trimediylmelamine
-
6-trimediylmelamine. Cancer Res. 49, 5475-5479.
-
(1989)
Cancer Res.
, vol.49
, pp. 5475-5479
-
-
Judson, I.R.1
Calvert, A.H.2
Rutty, C.J.3
Abel, G.4
Gumbrell, L.A.5
Graham, M.A.6
Evans, B.D.7
Wilman, D.E.V.8
Ashley, S.A.9
Cairnduff, F.10
-
21
-
-
0026027825
-
Phase II trial of trimelamol in refractory ovarian cancer
-
Judson I. R., Calvert A. H., Gore M. E., Balmonno K., Gumbrell L. A., Perren T. and Wiltshaw E. (1991) Phase II trial of trimelamol in refractory ovarian cancer. Br. J. Cancer 63, 311-313.
-
(1991)
Br. J. Cancer
, vol.63
, pp. 311-313
-
-
Judson, I.R.1
Calvert, A.H.2
Gore, M.E.3
Balmonno, K.4
Gumbrell, L.A.5
Perren, T.6
Wiltshaw, E.7
-
22
-
-
0016718848
-
Complexation in formulation of parenteral solutions: Solubilisation of the cytotoxic agent hexamethylmelamine by complexation with gentissic acid species
-
Kreilgard B. O., Higuchi T. and Repta A. J. (1975) Complexation in formulation of parenteral solutions: solubilisation of the cytotoxic agent hexamethylmelamine by complexation with gentissic acid species. J. Pharm. Sci. 64, 1850-1855.
-
(1975)
J. Pharm. Sci.
, vol.64
, pp. 1850-1855
-
-
Kreilgard, B.O.1
Higuchi, T.2
Repta, A.J.3
-
23
-
-
0017074849
-
Hexamethylmelamine: An evaluation of its role in the therapy of cancer
-
Legha S. S., Slavik M. and Carter S. K. (1976) Hexamethylmelamine: an evaluation of its role in the therapy of cancer. Cancer 38, 27-35.
-
(1976)
Cancer
, vol.38
, pp. 27-35
-
-
Legha, S.S.1
Slavik, M.2
Carter, S.K.3
-
24
-
-
0343790278
-
Relationship between cross-linking activity and cytotoxicity for a series of novel trimelamol analogues
-
Abstract 055, Amsterdam
-
Pennock J., Godfrey R., Saunders R. W., Hartley J. A. and Thurston D. E. (1994) Relationship between cross-linking activity and cytotoxicity for a series of novel trimelamol analogues. In 8th NCI-EORTC Symposium on New Drugs in Cancer Therapy (Abstract 055), p. 82. Amsterdam.
-
(1994)
8th NCI-EORTC Symposium on New Drugs in Cancer Therapy
, pp. 82
-
-
Pennock, J.1
Godfrey, R.2
Saunders, R.W.3
Hartley, J.A.4
Thurston, D.E.5
-
25
-
-
0019419134
-
Comparison of DNA damage by methylmelamines and formaldehyde
-
Ross W. E., McMillan D. R. and Ross C. F. (1981) Comparison of DNA damage by methylmelamines and formaldehyde. J. Natl. Cancer Inst. 67, 217-221.
-
(1981)
J. Natl. Cancer Inst.
, vol.67
, pp. 217-221
-
-
Ross, W.E.1
McMillan, D.R.2
Ross, C.F.3
-
26
-
-
0021215521
-
Studies of the mode of action of antitumour triazenes and triazines-V. The correlation of the in vitro cytotoxicity and in vivo antitumour activity of hexamethylmelamine analogues with their metabolism
-
Ross D. R., Langdon S. P., Gescher A. and Stevens M. F. G. (1984) Studies of the mode of action of antitumour triazenes and triazines-V. The correlation of the in vitro cytotoxicity and in vivo antitumour activity of hexamethylmelamine analogues with their metabolism. Biochem. Pharamc. 33, 1131-1136.
-
(1984)
Biochem. Pharamc.
, vol.33
, pp. 1131-1136
-
-
Ross, D.R.1
Langdon, S.P.2
Gescher, A.3
Stevens, M.F.G.4
-
27
-
-
0017655946
-
In vitro studies with hexamethylmelamine
-
Rutty C. J. and Connors T. A. (1977) In vitro studies with hexamethylmelamine. Biochem. Pharmac. 26, 2385-2391.
-
(1977)
Biochem. Pharmac.
, vol.26
, pp. 2385-2391
-
-
Rutty, C.J.1
Connors, T.A.2
-
28
-
-
0018844617
-
In vitro cytotoxicity of the methylmelamines
-
Rutty C. J. and Abel G. (1980) In vitro cytotoxicity of the methylmelamines. Chem. Biol. Interact. 29, 235-246.
-
(1980)
Chem. Biol. Interact.
, vol.29
, pp. 235-246
-
-
Rutty, C.J.1
Abel, G.2
-
29
-
-
0020068321
-
The comparative pharmacokinetics of pentamethylmelamine in man, rat and mouse
-
Rutty C. J., Newell D. R., Muindi J. R. F. and Harrap K. R. (1982) The comparative pharmacokinetics of pentamethylmelamine in man, rat and mouse. Cancer Chemother. Pharmac. 8, 105-111.
-
(1982)
Cancer Chemother. Pharmac.
, vol.8
, pp. 105-111
-
-
Rutty, C.J.1
Newell, D.R.2
Muindi, J.R.F.3
Harrap, K.R.4
-
30
-
-
0022532362
-
6-trimethylmelamine (trimelamol), a water soluble cytotoxic s-triazine which does not require metabolic activation
-
6-trimethylmelamine (Trimelamol), a water soluble cytotoxic s-triazine which does not require metabolic activation. Cancer Chemother. Pharmac. 17, 251-258.
-
(1986)
Cancer Chemother. Pharmac.
, vol.17
, pp. 251-258
-
-
Rutty, C.J.1
Judson, I.R.2
Abel, G.3
Goddard, P.M.4
Newell, D.R.5
Harrap, K.R.6
-
31
-
-
0021913998
-
Hexamethylmelamine, adriamycin and cyclophosphamide (HAC) versus cisdichlorodiamineplatinum, adriamycin and cyclophosphamide (PAC) in advanced ovarian cancer: A randomized clinical trial
-
Sessa C., Bolis G., Colombo N., D'Incalci M., Mermillod B., Valente and Mangioni C. (1985) Hexamethylmelamine, adriamycin and cyclophosphamide (HAC) versus cisdichlorodiamineplatinum, adriamycin and cyclophosphamide (PAC) in advanced ovarian cancer: a randomized clinical trial. Cancer Chemother. Pharmac. 14, 222-228.
-
(1985)
Cancer Chemother. Pharmac.
, vol.14
, pp. 222-228
-
-
Sessa, C.1
Bolis, G.2
Colombo, N.3
D'Incalci, M.4
Mermillod, B.5
Valente6
Mangioni, C.7
|