Effects of multiple intracerebroventricular injections of [D-Pen2,D-Pen5[enkephalin and [D-Ala2,Glu4]deltorphin II on tolerance to their analgesic action and on brain δ-opioid receptors

Brain Research

Volumn 745, Issue 1-2, 1997, Pages 243-247

  Zhao, Guo Min ^a   Bhargava, Hemendra N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

1 , 2 Opioid receptor agonist; D Ala2,Glu4 deltorphin II; D Pen2,D Pen5 enkephalin; Analgesia; Brain receptor; Tolerance

Indexed keywords

DELTA OPIATE RECEPTOR; DELTORPHIN DERIVATIVE; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; OPIATE AGONIST; RADIOLIGAND; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG TOLERANCE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

ANALGESICS, OPIOID; ANIMALS; BRAIN CHEMISTRY; CELL MEMBRANE; DRUG TOLERANCE; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; INJECTIONS, INTRAVENTRICULAR; KINETICS; MALE; MICE; OLIGOPEPTIDES; RECEPTORS, OPIOID, DELTA;

EID: 0031033004     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01156-0     Document Type: Article

References (16)

1. Bhargava, H.N., Multiple opiate receptors of brain and spinal cord in opiate addiction, Gen. Pharmacol., 22 (1991) 767-772.
2. Bhargava, H.N., Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome and self-administrative behavior, Pharmacol. Rev., 46 (1994) 293-324.
3. 2 opioid receptor agonists in mice, Brain Res., 719 (1996) 56-61.
4. 5]enkephalin and morphine in mice, Neuropeptides, 30 (1996) 219-223.
5. 2 opioid receptor agonists in mice, Br. J. Pharmacol., (1996) in press.
6. 2-opioid receptor agonists, Eur. J. Pharmacol., 311 (1996) 127-132.
7. Haley, T.J. and McCormick, W.G., Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse, Br. J. Pharmacol. Chemother., 12 (1957) 12-15.
8. Jenab, S., Kest, B. and Inturrisi, C.E., Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment, Brain Res., 691 (1995) 69-75.
9. 6]enkephalin and naltrindole 5-isothiocyanate: evidence for delta receptor subtypes, J. Pharmacol. Exp. Ther., 257 (1991) 1069-1075.
10. 2]deltorphin II tolerance mice, J. Neurosci. Res., 39 (1994) 674-679.
11. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193 (191) 265-275.
12. Magnan, C., Peterson, S.J., Tavani, A. and Kosterlitz, H.W. The binding spectrum of narcotic analgesic drugs with different agonists and antagonist properties, Naunyn-Schmiedebergs Arch. Pharmacol., 319 (1982) 197-205.
13. 2]deltorphin II in mice: evidence for delta receptor subtypes, J. Pharmacol. Exp. Ther., 258 (1991) 583-587.
14. Munson, P.J. and Rodbard, D., LIGAND: a versatile, computerized approach for the characterization of ligand binding systems, Anal. Biochem., 107 (1980) 220-239.
15. 1-opioid receptor agonist in mice, Peptides, 17 (1996) 233-236.
16. 4]deltorphin II in mice, Peptides, 17 (1996) 619-623.