Differing effects of aprotinin and ε-aminocaproic acid on cytokine-induced inducible nitric oxide synthase expression

Annals of Thoracic Surgery

Volumn 63, Issue 1, 1997, Pages 74-77

  Hill, Gary E ^a,b   Taylor, Janice A ^b   Robbins, Richard A ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; APROTININ; GAMMA INTERFERON; INTERLEUKIN 1BETA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; EPITHELIUM CELL; HEART SURGERY; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

6-AMINOCAPROIC ACID; ANIMALS; APROTININ; BLOTTING, NORTHERN; CELL LINE; CYTOKINES; EPITHELIAL CELLS; LUNG; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; SERINE PROTEINASE INHIBITORS;

EID: 0031032874     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(96)00833-8     Document Type: Article

References (21)

1. Royston D. Blood-sparing drugs aprotinin, tranexamic acid, and ε-aminocaproic acid . Int Anesthesiol Clin. 33:1995;155-179.
2. Kleniewski J, Blankenship DT, Cardin AD, Donaldson V. Mechanism of enhanced kinin release from high molecular weight kininogen by plasma kallikrein after its exposure to plasmin. J Lab Clin Med. 120:1992;129-139.
3. Hill GE, Alonso A, Spurzem JR, Stammers AH, Robbins RA. Aprotinin and methylprednisolone equally blunt cardiovascular bypass-induced inflammation in humans. J Thorac Cardiovasc Surg. 110:1995;1658-1662.
4. Swartholm E, Haglund U, Ljungberg J, Hedner U. Influence of aprotinin, a protease inhibitor, on porcine E. coli shock. Acta Chir Scand. 155:1989;7-13.
5. Kongsgaard UE, Smith-Erichsen N, Geiran O, Amundsen E, Mollnes TE, Garred P. Different activation patterns in the plasma kallikrein-kinin and complement systems during coronary bypass surgery. Acta Anaesthesiol Scand. 33:1989;343-347.
6. Wachtfogel YT, Hack CE, Nuijens JH, et al. Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation. Am J Physiol. 268:1995;H1352-7.
7. Ruvolo G, Greco E, Speziale G, Tritapepe L, Marino B. Nitric oxide formation during cardiopulmonary bypass. Ann Thorac Surg. 57:1994;1055-1056.
8. 2+-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass. Thorax. 50:1995;403-404.
9. Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction. Am J Physiol. 270:1996;G225-37.
10. Matheis G, Sherman MP, Buckberg GD, Haybron DM, Young HH, Ignarro NJ. Role of 1-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol. 262:1992;H616-20.
11. Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate comparison with enzymatically formed nitric oxide from l-arginine . Proc Natl Acad Sci USA. 90:1993;8103-8107.
12. Archer SA. Measurement of nitric oxide in biologic models. FASEB J. 7:1993;349-360.
13. Robbins RA, Springall DR, Warren JB, et al. Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem Biophys Res Commun. 198:1994;835-843.
14. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
15. Xie QW, Cho HJ, Calaycay J, et al. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 256:1992;225-228.
16. Walter R, Schaffner A, Schoedon G. Differential regulation of constitutive and inducible nitric oxide production by inflammatory stimuli in murine endothelial cells. Biochem Biophys Res Commun. 202:1994;450-455.
17. Casey LC. Roles of cytokines in the pathogenesis of cardiopulmonary-induced multisystem organ failure. Ann Thorac Surg. 56:1993;S92-6.
18. Kim H, Lee HS, Chang KT, Ko TH, Baek KJ, Kwon NS. Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-κB. J Immunol. 154:1995;4741-4748.
19. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem. 269:1994;4705-4708.
20. Wendel HP, Heller W, Michel J, et al. Lower cardiac tropinin T levels in patients undergoing cardiopulmonary bypass and receiving high-dose aprotinin therapy indicate reduction of perioperative myocardial damage. J Thorac Cardiovasc Surg. 109:1995;1164-1172.
21. Hennein HA, Ebba H, Rodriguez JL, et al. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization. J Thorac Cardiovasc Surg. 108:1994;626-635.