Modulation by the endothelium of the inhibitory effects of pinacidil and nimodipine on endothelin-induced contraction in cerebral arteries

Pharmacology and Toxicology

Volumn 80, Issue 1, 1997, Pages 30-37

  Petersson, Jesper ^a   Andersson, Karl Erik ^a   Brandt, Lennart ^a   Högestätt, Edward D ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ENDOTHELIN 1; INDOMETACIN; N(G) NITRO DEXTRO ARGININE; N(G) NITROARGININE; NICKEL; NIMODIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PINACIDIL;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BASILAR ARTERY; BRAIN ARTERY; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; NORMAL HUMAN; PIA ARTERY; PRIORITY JOURNAL;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031032324     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00280.x     Document Type: Article

References (55)

1. Adner, M., I. Jansen & L. Edvinsson: Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries. J. Auton. Nerv. Syst. 1994, 49(S), S117-S121.
2. Andersson, K.-E.: Clinical pharmacology of potassium channel openers. Pharmacology Toxicology 1992, 70, 244-254.
3. Auch-Schwelk, W. & P. M. Vanhoutte: Calcium antagonists inhibit contractions to norepinephrine in the rat aorta, in the absence, but not in the presence of the endothelium. Gen. Pharmacol. 1991, 22, 595-602.
4. Barone, F. C., M. Y. Globus, W. J. Price, R. F. White, B. L. Storer, G. Z. Feuerstein, R. Busto & E. H. Ohlstein: Endothelin levels increase in rat focal and global ischemia. J. Cereb. Blood Flow Metab. 1994, 14, 337-342.
5. Bian, L. G., T. X. Zhang, W. G. Zhao, J. K. Shen & G. Y. Yang: Increased endothelin-1 in the rabbit model of middle cerebral artery occlusion. Neurosci. Lett. 1994, 174, 47-50.
6. Bolotina, V. S. Najibi, J. J. Palacino, P. J. Pagano & R. A. Cohen: Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 1994, 368, 850-853.
7. Cain, C. R. & C. D. Nicholson: Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations. Naunyn-Schmiedeberg's Arch. Pharmacol. 1989, 340, 293-299.
8. A receptors predominate in the human vasculature and mediate constriction. J. Cardiovasc. Pharmacol. 1995, 26(S3), S265-S267.
9. Diéguez, G., J. L. Garcia, N. Fernándes, A. L. Garcia-Villalón, L. Monge & B. Gómez: Cerebrovascular and coronary effects of endothelin-1 in the goat. Amer. J. Physiol. 1992, 263, R834-R839.
10. Edwards, G. & A. H. Weston: Effect of potassium channel modulating drugs on isolated smooth muscle. In: Handbook of experimental pharmacology. Volume III. Eds.: Szekeres and Papp. Springer, Heidelberg 1994, 469-531.
11. Encabo, A., M. Ferrer, J. Marin, J. Villamor & G. Balfagón: Vasoconstrictive responses elicited by endothelin in bovine cerebral arteries. Gen. Pharmacol. 1992, 23, 269-267.
12. Faraci, F. M.: Endothelium-derived vasoactive factors and regulation of the cerebral circulation. Neurosurgery 1993, 33, 648-659.
13. Feger, G. I., L. Schilling, H. Ehrenreich & M. Wahl: Endothelin-induced contraction and relaxation of rat isolated basilar artery: effect of BQ 123. J. Cereb. Blood Flow Metab. 1994, 14, 845-852.
14. Fox, A. P., M. Nowycky & R. W. Tsien: Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol. 1987, 394, 149-172.
15. Fuxe, K., N. Kurosawa, A. Cintra, Ȧ. Hallström, M. Goiny, L Rosén, L. F. Agnati & U. Ungerstedt: Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat. Exp. Brain Res. 1992, 88, 131-139.
16. Garcia, J. L., L. Monge, B. Gómez & G. Diéguez: Response of canine cerebral arteries to endothelin-1. J. Pharm. Pharmacol. 1991, 43, 281-284.
17. Garland, C. J. & G. A. McPherson: Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Brit. J. Pharmacol. 1992, 105, 429-435.
18. Gelmers, H. J.: Effect of nimodipine (Bay e 9736) on postischaemic cerebrovascular reactivity, as revealed by measuring regional cerebral blood flow (rCBF). Acta neurochirur. 1982, 63, 283-290.
19. Giuffrida, R., M. Bellomo, G. Polizzi & L. S. Malatino: Ischemia-induced changes in the immunoreactivity for endothelin and other vasoactive peptides in the brain of the mongolian gerbil. J. Cardiovasc. Pharmacol. 1992, 22, S41-S44.
20. Harder, D. R., P. Dernbach & A. Waters: Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid haemorrhage in the dog. J. Clin. Invest. 1987, 80, 875-880.
21. Hatake, K., I. Wakabayashi, E. Kakishita & S. Hishida: Impairment of endothelium-dependent relaxation in human basilar artery after subarachnoid haemorrhage. Stroke 1992, 23, 1111-1117.
22. Hearse, D. J.: Activation of ATP-sensitive potassium channels: a novel pharmacological approach to myocardial protection? Curdiovasc. Res. 1995, 30, 1-17.
23. Hempelmann, R. G., H. L. Barth, H. M. Mehdorn, R. H. E. Pradel & A. Ziegler: Effects of potassium channel openers in isolated human cerebral arteries. Neurosurgery 1995, 37, 1146-1153.
24. + channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid b-protein precursor genes and neuronal death in rat hippocampus. Proc. Natl. Acad. Sci. USA 1993, 90, 9431-9435.
25. Högestätt, E. D., K.-E. Andersson & L. Edvinsson: Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta physiol. scand. 1983, 117, 49-61.
26. Itoh, T., H. Kuriyama & H. Suzuki: Excitation-contraction coupling in smooth muscle cells of the guinea-pig mesenteric artery. J. Physiol. 1981, 321, 513-535.
27. Jansen, I., B. Fallgren & L. Edvinsson: Mechanisms of action of endothelin on isolated feline cerebral arteries: In vitro pharmacology and electrophysiology. J. Cereb. Blood Flow Metab. 1989, 9, 743-747.
28. 2+ store overlaps with caffeine-sensitive one in rat aortic smooth muscle cells in primary culture. Biochem. Biophys. Res. Commun. 1989, 158, 235-243.
29. Kauser, K., G. M. Rubanyi & D. R. Harder: Endothelium-dependent modulation of endothelin-induced vasoconstriction and membrane depolarization in cat cerebral arteries. J. Pharmacol. Exp. Therap. 1990, 252, 93-97.
30. Krippeit-Drews, P., N. Morel & T. Godfraind: Effect of nitric oxide on membrane potential and contraction of rat aorta. J. Cardiovasc. Pharmacol. 1992, 20(S12), S72-S75.
31. Ksoll, E., A. A. Parsons, J. R. L. Mackert, L. Schilling & M. Wahl: Analysis of cromakalim-, pinacidil-. and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 1991, 343, 377-383.
32. Langley, M. S. & E. M. Sorkin: Nimodipine: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cerebrovascular disease. Drugs 1989, 37, 669-699.
33. Martin de Aguilera, E., A. Irurzun, J. M. Vila, M. Aldasoro, M. S. Galeote & S. Lluch: Role of endothelium and calcium channels in endothelin-induced contraction of human cerebral arteries. Brit. J. Pharmacol. 1990, 99, 439-440.
34. Mayhan, W. G., S. M. Amundsen, F. M. Faraci & D. D. Heistad: Responses of cerebral arteries after ischemia and reperfusion in cats. Amer. J. Physiol. 1988, 255, H879-H884.
35. Nakagomi, T., N. F. Kassell, T. Sasaki, S. Fujiwara, R. M. Lehmann & J. C. Torner: Impairment of endothelium-dependent vasodilation induced by acetylcholine and adenosine triphosphate following experimental subarachnoid hemorrhage. Stroke 1987, 18, 482-489.
36. Nakajima, S. & M. Ueda: Pharmacological studies on pinacidil, a new antihypertensive agent.(3). Studies on the vasodilating effects in isolated monkey arteries and the peripheral hypotensive mechanism in SHR. Nippon Yakurigaku Zasshi 1987, 90, 13-21.
37. Nishigaya, K., Y. Yoshida, M. Sasuga, H. Nukui & G. Ooneda: Effect of recirculation on exacerbation of ischemic vascular lesions in rat brain. Stroke 1991, 22, 635-642.
38. Parkington, H. C., M. A. Tonta, H. A. Coleman & M. Tare: Role of membrane potential in endothelium-dependent relaxation of guinea-pig coronary arterial smooth muscle. J. Physiol. 1995, 484.2, 469-480.
39. Petersson, J., T. Ryman & E. D. Högestätt: Enhancement of depolarization-induced contractions after endothelium denudation is not related to an impaired production of nitric oxide or prostacyclin in the rabbit basilar artery. Acta physiol. scand. 1993, 149, 467-474.
40. Quast, U.: Do the K channel openers relax smooth muscle by opening K channels. Trends Pharmacol. Sci. 1993, 14, 332-337.
41. Randall, M. D.: Vascular activities of the endothelins. Pharmacol. Ther. 1991, 50, 73-93.
42. Robertson, B. E., R. Schubert, J. Hescheler & M. T. Nelson: cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Amer. J. Physiol. 1993, 265, C299-C303.
43. Rubanyi, G. M. & M. A. Polokoff: Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 1994, 46, 325-415.
44. Ryman, T., J. Petersson, K.-E. Andersson, L. Brandt & E.D. Högestätt: Effects of pinacidil on cerebral and mesenteric arteries - influence of the endothelium. Naunyn-Schmiedeberg's Arch. Pharmacol. 1993, 348, 298-304.
45. Salom, J. B., G. Torregrosa, F. J. Miranda, J. A. Alabadi, C. Alvarez & E. Alborch E: Effects of endothelin-1 on the cerebrovascular bed of the goat. Eur. J. Pharmacol. 1991, 192, 39-45.
46. + channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells. Pflügers Arch. 1993, 423, 167-172.
47. Toda, N., S. Nakajima, M. Miyazaki & M. Ueda: Vasodilatation induced by pinacidil in dogs. Comparison with hydralazine and nifedipine. J. Cardiovasc. Pharmacol. 1985, 7, 1118-1126.
48. Tare, M., H. C. Parkington, H. A. Coleman, T. O. Neild & G. J. Dusting: Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature 1990, 346, 69-71.
49. Wahl, M.: The effects of pinacidil and tolbutamide in feline pial arteries in situ. Pflügers Arch. 1989, 415, 250-252.
50. m. Stroke 1985, 16, 990-997.
51. von Mecklenburg, C., J.-Y. Chang, T. Delgado, C. Owman, C. Sahlin & N.-A. Svendgaard: Ultrastructural cerebrovascular changes in a model of subarachnoid haemorrhage in baboon based on triple cisternal blood injection. Surg. Neurol. 1990, 33, 195-201.
52. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K., Goto & T. Masaki: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988, 33, 411-415.
53. Zhang, H., N. Stockbridge, B. Weir, B. Vollrath & D. Cook: Vasodilatation of canine cerebral arteries by nicorandil and lemakalim. Gen. Pharmacol. 1992, 23, 197-201.
54. Zhang, H. & D. Cook: Cerebral vascular smooth muscle potassium channels and their possible role in the management of vasospasm. Pharmacology Toxicology 1994, 75, 327-336.
55. + channel activator cromakalim. Stroke 1996, 27, 311-316.