A comparison of bactericidal/permeability-versus increasing protein variant recombinant endotoxin-neutralizing protein for the treatment of Escherichia coli sepsis in rats

Critical Care Medicine

Volumn 25, Issue 1, 1997, Pages 101-105

  Stack, Anne M ^a   Saladino, Richard A ^a   Siber, George R ^b   Thompson, Claudette ^b   Marra, Marian N ^c   Novitsky, Thomas J ^d   Fleisher, Gary R ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Experimental Station   (United States)

^d Associates of Cape Cod Inc   (United States)

Author keywords

animal model; antibiotics; bactericidal permeability increasing protein; endotoxin neutralizing protein; Escherichia coli; peritonitis; sepsis

Indexed keywords

BACTERICIDE; CEFTRIAXONE; ENDOTOXIN; GENTAMICIN; RECOMBINANT NEUTRALIZING PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DOSE RESPONSE; ESCHERICHIA COLI; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SEPSIS; SURVIVAL RATE;

ANIMALS; ANTI-INFECTIVE AGENTS; CEFTRIAXONE; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ESCHERICHIA COLI INFECTIONS; GENTAMICINS; GRAM-NEGATIVE BACTERIAL INFECTIONS; MALE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SEPSIS; SURVIVAL ANALYSIS;

EID: 0031032236     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199701000-00020     Document Type: Article

References (15)

1. Wainwright N, Miller R, Paus E, et al: Endotoxin binding and neutralizing activity by a protein from Limulus polyphemus. In: Cellular and Molecular Aspects of Endotoxin Reactions. Nowotny A, Spitzer J, Ziegler A (Eds). Amsterdam, Elsevier, 1990, pp 315-325
2. Ohashi K, Niwa M, Nakamura T, et al: Anti-LPS factor in the horseshoe crab, T. tridentatus. Its hemolytic activity on the red blood cell sensitized with lipopolysaccharide. FEBS Lett 1984; 176:207-210
3. Desch CE, O'Hara P, Harlan J: Antilipopolysaccharide factor from the horseshoe crab, T. tridentatus, inhibits lipopolysaccharide activation of cultured human endothelial cells. Infect Immun 1989; 57:1612-1614
4. Niwa M, Hua H, Iwanga S, et al: Biological activities of anti-LPS factor and LPS binding peptide from horseshoe crab amoebocytes. Adv Exp Med Biol 1990; 256:257-271
5. Alpert G, Baldwin G, Thompson C, et al: Limulus antilipopolysaccharide factor protects rabbits from meningococcal endotoxin shock. J Infect Dis 1992; 165:494-500
6. Garcia C, Saladino R, Thompson C, et al: Effect of a recombinant endotoxin-neutralizing protein on endotoxin shock in rabbits. Crit Care Med 1994; 22: 1211-1218
7. Saladino R, Garcia C, Thompson C, et al: Efficacy of a recombinant endotoxin neutralizing protein in rabbits with E. coli sepsis. Circ Shock 1994; 42:104-110
8. Kuppermann N, Nelson D, Saladino R, et al: A randomized trial of a recombinant endotoxin neutralizing protein versus a monoclonal antibody to endotoxin for the treatment of E. coli sepsis in a rat model. J Infect Dis 1994; 170:630-635
9. Weiss J, Olsson I: Cellular and subcellular localization of the bactericidal/ permeability-increasing protein of neutrophils. Blood 1987; 69:652-659
10. Elsbach P, Weiss J: The bactericidal/ permeability-increasing protein, a potent element of the host defense against Gram-negative bacteria and lipopolysaccharide. Immunobiology 1993; 187: 417-429
11. Opal SM, Fisher CJ, Marra MN, et al: Bactericidal/permeability increasing protein as a novel therapeutic modality in the treatment of endotoxin shock. Abstr. Clin Res 1991; 39:351A
12. Fisher CJ, Marra MN, Palardy JE, et al: Human neutrophil bactericidal/permeability-increasing protein reduces mortality rate from endotoxin challenge: A placebo-controlled study. Crit Care Med 1994; 22:553-558
13. Marra MN, Thornton MB, Snable JL, et al: Endotoxin-binding and -neutralizing properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5. Crit Care Med 1994; 22:559-565
14. Wilde CG, Seilhamer JJ, McGrogan M, et al: Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein: LPS binding properties and effects on LPS-mediated cell activation. J Biol Chem 1994; 269:17411-17416
15. Hoess A, Watson S, Siber GR, et al: Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 Å resolution. EMBO J 1993; 12:3351-3356