Contrary roles of IL-4 and IL-12 on IL-10 production and proliferation of human tumour reactive T cells

Scandinavian Journal of Immunology

Volumn 45, Issue 2, 1997, Pages 221-226

  Heike, M ^a   Schlaak, J ^a   Heyl, S ^a   Schulze Bergkamen, H ^a   Schmitt, U ^a   Meyer Zum Buschenfelde K H ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4;

ADULT; ARTICLE; CELL LINE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; SARCOMA; T LYMPHOCYTE; TUMOR IMMUNITY;

EID: 0031032008     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-386.x     Document Type: Article

References (26)

1. Levitsky HI, Lazenby A, Hayashi R, Pardoll DM. In vivo priming of two distinct anti tumor effector populations: the role of MHC class 1 expression. J Exp Med 1994;179:1215-24.
2. Awwad M, North RJ. Radiosensitive barrier to T-cell-mediated adoptive immunotherapy of established tumors. Cancer Res 1990;50:2228-33.
3. Martinotti A, Stoppacciaro A, Vagliani M et al. CD4 T cells inhibit in vivo the CDS mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes. Eur J Immunol 1995;25:137-46.
4. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995;16:34-8.
5. + T lymphocytes recognize human melanoma antigens processed and presented by Epstein-Barr virus-transformed B cells. Int J Cancer 1994;58:69-79.
6. + T lymphocytes against human melanoma. Evidence for a shared melanoma antigen presented by HLA-DRI. Immunol 1995;154:772-9.
7. + HLA class II-restricted T cell clones against a human sarcoma. Evidence for several recognized antigens. J Immunol 1996;156:2205-13.
8. Herin M, Lemoine C, Weynants P et al. Production of stable cytolytic T-cell clones directed against autologous human melanoma. Int J Cancer 1987;39:390-6.
9. Espevik T, Nissen-Meyer J. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods 1986; 95:99-105.
10. Hansen MB, Nielsen SE, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 1989;95:99-105.
11. Schlaak J, Hermann E, Ringhoffer M et al. Predominance of Th1-type T cells in synovial fluid of patients with yersinia-induced reactive arthritis. Eur J Immunol 1992;22:2771-6.
12. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993;11:165-90.
13. Chen WF, Zlotnik A. IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 1991;147:528-34.
14. Heike M, Schmitt U, Höhne A, Huber C, Meyer zum Büschen elde K-H, Seliger B. Impaired HLA-class I stability in a sarcoma cell line which stimulates exclusively HLA-class II restricted autologous T cells. Int J Cancer 1996;67:743-8.
15. Bradley LM, Yoshimoto K, Swain SL. The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J Immunol 1995;155:1713-24.
16. Mocci S, Coffman RL. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. Immunol 1995;154:3779-87.
17. Parronchi P, De Carli M, Manetti R et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J Immunol 1992;149:2977-83.
18. Ghalib HW, Whittle JA, Kubin M et al. IL-12 enhances Th1-type responses in human Leishmania donovani infections. J Immunol 1995;154:4623-9.
19. Manetti R, Parronchi P, Giudizi MG et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type I (Th1)-specific immune responses and inhibits the development of IL-4-prixlucing Th cells. J Exp Med 1993;177:1199-204.
20. Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988;140:4245.
21. Meyaard L, Hovenkamp E, Otto SA, Miedema F. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J Immunol 1996;156:2776-82.
22. Gerosa F, Paganin C, Peritt D et al. Interleukin-12 primes human CD4 and CDS T cell clones for high production of both Interferon-γ and inlerleukin-1. Exp Med 1996;183:2559-69.
23. Morris SC, Madden KB, Adamovicz JJ et al. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol 1994;152:1047-56.
24. Brunda MJ, Luistro L, Warrier RR et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993;178:1223-30.
25. + T cells. J Exp Med 1996;184:19-29.
26. Cohen J. IL-12 deaths: explanation and a puzzle. Science 1995;270:908.