Antitumor agents. 168. Dysoxylum cumingianum. IV. The structures of cumingianosides G-O, new triterpene glucosides with a 14,18- cycloapotirucallane-type skeleton from Dysoxylum cumingianum, and their cytotoxicity against human cancer cell lines

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 1, 1997, Pages 68-74

  Fujioka, Toshihiro ^a   Sakurai, Akio ^a   Mihashi, Kunihide ^a   Kashiwada, Yoshiki ^b   Chen, Ih Sheng ^c   Lee, Kuo Hsiung ^d  

^a FUKUOKA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

14,18 cycloapotirucallane glucoside; cytotoxicity; Dysoxylum cumingianun; Meliaceae; triterpene; triterpene glucoside

Indexed keywords

ANTINEOPLASTIC AGENT; CUMINGIANOSIDE M; GLUCOSIDE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MELANOMA CELL; PLANT LEAF;

EID: 0031031683     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.68     Document Type: Article

References (8)

1. Johnson M. G., Kiyokawa H., Koyama J., Morris-Natshke S. L., Bowers-Daines M. M., Lange B. C., Lee K. H., J. Med. Chem., submitted.
2. a) Kashiwada Y., Fujioka T., Chang J. J., Chen S. I., Mihashi K., Lee K. H., Bioorganic & Medicinal Chemistry Letters, 2, 395-398 (1992);
3. b) Idem, J. Org. Chem., 57, 6946-6953 (1992);
4. c) Kashiwada Y., Fujioka T., Mihashi K., Marubayashi N., Mizuki K., Chen I. S., Lee K. H., J. Nat. Prod., 58, 495-503 (1995).
5. 2c) the skeleton type should be revised to 14,18-cycloapotirucallane.
6. Dev S., Nagasampagi B. A., "CRC Handbook of Terpenoids. Triterpenoids," Vol. I, CRC Press Inc., Boca Raton, Florida, 1989, pp. 32-33.
7. 50 values were shown incorrectly as μg/ml.
8. Boyd M. B., Paul K. D., Drug. Development Res., 34, 91-109 (1995).