Expression of epidermal growth factor-related proteins in the aged adult mouse mammary gland and their relationship to tumorigenesis

Journal of Cellular Physiology

Volumn 170, Issue 1, 1997, Pages 47-56

  Herrington, Eugene E ^a   Ram, Tracy G ^a   Salomon, David S ^b   Johnson, Gibbes R ^c   Gullick, William J ^d   Kenney, Nicholas ^e   Hosick, Howard L ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

^e GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; CARCINOGENESIS; HISTOLOGY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGING; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOGENS; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; GROWTH SUBSTANCES; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; NEOPLASM PROTEINS; PREGNANCY; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR MARKERS, BIOLOGICAL;

EID: 0031031567     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199701)170:1<47::AID-JCP6>3.0.CO;2-L     Document Type: Article

References (49)

1. Arrick, B.A., Lee, A., Grendell, R., and Derynck, R. (1991) Inhibition of translation of transforming growth factor-beta 3 by its 5′ untranslated region. Mol. Cell. Biol., 11:4306-4313.
2. Bates, B., Hardin, J., Zhan, X., Drickamer, K., and Goldfarb, M. (1991) Biosynthesis of human fibroblast growth factor-5. Mol. Cell. Biol., 11:2149-2153.
3. Bates, S.E., Davidson, N.E., Valverius, E.M., Freter, C.E., Dickson, R.B., Tam, J.P., Kudlow, J.E., Lippman, M.E., and Salomon, D.S. (1988) Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer; its regulation by estrogen and its possible functional significance. Mol. Endocrinol., 2:543-555.
4. Bello-Fernandez, C., Packham, G., and Cleveland, J.L. (1993) The ornithine decarboxyalase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. U. S. A., 90:7804-7808.
5. Brandt, R., Normanno, N., Gullick, W.J., Harkins, R., Schneider, D., Jones, B-W., Ciardiello, F., Kim, N., and Salomon, D.S. (1994) Identification and characterization of an epidermal growth factor-related protein: Cripto-1. J. Biol. Chem., 269:17320-17328.
6. Brown, C.F., Teng, C.T., Pentecost, B.T., and DiAugustine, R.P. (1989) Epidermal growth factor precursor in mouse lactating mammary gland alveolar cells. Mol. Endocrinol., 3:1077-1083.
7. Chomczynski, P., and Sacchi, N. (1987) Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162:156-159.
8. Ciardiello, F., Kim, N., Liscia, D.S., Bianco, C., Liderau, R., Merlo, G., Callahan, R., Brattain, M., Greiner, J., Szpak, C., Kidwell, W., Derynck, R., Schlom, L., and Salomon, D.S. (1989) mRNA expression of transforming growth factor alpha in human breast carcinomas and its activity in effusions of breast cancer patients. J. Natl. Cancer Inst., 81:1165-1171.
9. Ciardiello, F., McGeady, M.L., Kim, N., Basolo, F., Hynes, N., Langsten, B., Yokozaki, H., Saeki, T., Elliot, J.W., Masui, H., Mendelsohn, J., Soule, H., Russo, J., and Salomon, D.S. (1990) Transforming growth factor-alpha expression is inhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary cDNA leads to transformation. Cell Growth Differ., 1:463-472.
10. Ciardiello, F., Dono, R., Kim, N., Persico, M.G., and Solomon, D.S. (1991) Expression of cripto, a novel gene of the epidermal growthfactor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line. Cancer Res., 51:1051-1054.
11. Ciccodicola, A., Dono, R., Obici, S., Simeone, A., Zollo, M., and Persico, M.G. (1989) Molecular characterization of a gene of the EGF family expressed in undifferentiated human NTERA-2 tetracarcinoma cells. EMBO J., 8:1887-1991.
12. Cohen, S.M., and Ellwein, L.B. (1990) Cell proliferation in carcinogenesis. Science, 249:1007-1011.
13. Dono, R., Scalera, L., Pacifico, F., Acampora, D., Persico, M.G., and Simeone, S. (1993) The murine cripto gene: Expression during mesoderm induction and early heart morphogenesis. Development, 118:1157-1168.
14. Di Marco, E., Pierce, J.H., Fleming, T.P., Kraus, M.H., Molloy, C.J., Aaronson, S.A., and Di Fiora, P.P. (1989) Autocrine interaction between TGFα and the EGF-receptor: Quantitative requirements for induction of the malignant phenotype. Oncogene, 4:831-838.
15. Harigaya, T., Tsunoda, S., Yokoyama, H., Yamamoto, K., and Nagasawa, H. (1994) Mouse TGFa gene expression in normal and neoplastic mammary glands and uteri of four strains of mice with different potentials for mammary gland growth and uterine adenomysis. Zoological Science, 11:841-846.
16. Humason, G.L. (1979) Animal Tissue Techniques. W.H. Freeman Company, San Francisco.
17. Jhappan, C., Stahale, C., Harkins, R.N., Fausto, N., Smith, G.H., and Merlino, G.T. (1990) TGF alpha expression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61:1137-1146.
18. Johnson, G.R., Kannan, B., Shoyab, M., and Stromberg, K. (1993) Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185 erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. J. Biol. Chem., 268:2924-2931.
19. Karabela-Bouropoulou, V., Liapi-Avgeri, G., Lliopoulou, E., and Agnantis, N.J. (1994) Histological findings in breast tissue specimens from reduction mammoplasties. Pathol. Res. Pract., 190:792-798.
20. Kenney, N., Johnson, G.R., Selvam, M.P., Kim, N., Qi, C.-F., Saeki, T., Brandt, R., Wallace-Jones, B., Ciardiello, F., Shoyab, M., Plowman, G., Day, A., Salomon, D.S., and Normanno, N. (1993) Transforming growth factor α (TGFα) and amphiregulin (AR) as autocrine growth factors in nontransformed, immortalized 18A1N4 human mammary epithelial cells. Mol. Cell. Differ., 1:163-184.
21. Kenney, N., Huang, R.-P., Johnson, G.R., Wu, J.-X., Oakamura, D., Matheny, W., Kordon, E., Gullick, W.J., Plowman, G.R., Smith, G.H., Salomon, D.S., and Adamson, E.D. (1995) Detection and localization of amphiregulin and cripto-1 in the developing mouse mammary gland. Mol. Reprod. Dev., 41:277-286.
22. Kenney, N., Hosick, H.L., Herrington, E.E., and Smith, G. (1996) The aged mammary gland. In: Pathobiology of the Aging Mouse. Vol. II. U. Mohr, I.L. Dungworth, J. Ward, C.C. Capen, W. Carleton, and J. Sundberg, eds. ILSI Press, Washington, D.C., pp 369-379.
23. Kozak, M. (1989) Circumstances and mechanisms of inhibition of translation by secondary structure in eukaryotic mRNAs. Mol. Cell. Biol., 9:5134-5142.
24. Lazaris-Karatzas, A., Montine, K.S., and Sonenberg, N. (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature, 345:544-547.
25. Liscia, D.S., Merlo, C., Ciardiello, F., Kim, N., Smith, G.H., Callahan, R., and Salomon, D.S. (1990) Transforming growth factor-alpha messanger RNA localization in the developing adult rat and human mammary gland by in situ hybridization. Dev. Biol., 140:123-131.
26. Lyons, R.M., and Moses, H.L. (1990) Transforming growth factors and the regulation of cell proliferation. Eur. J. Biochem., 187:467-473.
27. Maniatis, T., Fritch, E.F., and Sambrook, J. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
28. Matsui, Y., Halter, S.A., Holt, J.H., Hogan, B.L.M., and Coffey, R.J. (1990) Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell, 61:1147-1155.
29. McGeady, M.L., Kerby, S., Shankar, V., Ciardiello, F., Salomon, D.S., and Siedman, M. (1989) Infection with a TGFα retroviral vector transforms mouse mammary epithelial cells but not normal fibroblasts. Oncogene, 4:1375-1382.
30. Medina, D., Kittrell, F.S., Liu, Y.-J., and Schwartz, M. (1993) Morphological and functional properties of TM preneoneoplastic mammary outgrowths. Cancer Res., 53:663-667.
31. Mizokami, A., and Chang, C. (1994) Induction of translation by the 5′ untranslated region of human androgen receptor mRNA. J. Biol. Chem., 269:25655-25659.
32. Murphy, L.C., Dotzlaw, H., Wong, M.S.J., Millet, T., Mrockowski, B., Gong, Y., and Murphy, L.J. (1990) Epidermal growth factor: Receptor and ligand expression in human breast cancer. Semin. Cancer Biol., 1:305-315.
33. Normanno, N., Qi, C.-F., Gullick, W.J., Persico, G., Yarden, Y., Wen, D., Plowman, G., Kenney, N., Johnson, G., Kim, N., Brandt, R., Martinez-Lacaci, I., Dickson, R.B., and Salomon, D.S. (1993) Expression of amphiregulin, cripto-1 and heregulin a in human breast cancer cells. Int. J. Oncol., 2:903-911.
34. Normanno, N., Selvam, M.P., Qi, C.-F., Saeki, T., Johnson, G.R., Kim, N., Ciardiello, F., Shoyab, M., Plowman, G., Brandt, R., Todaro, G., and Salomon, D.S. (1994a) Amphiregulin as an autocrine growth factor in c-Ha-ras and c-erbB-2-transformed human mammary epithelial cells. Proc. Natl. Acad. Sci. U. S. A., 91:2790-2794.
35. Normanno, N., Ciardiello, F., Brandt, R., and Salomon, D.S. (1994b) Epidermal growth factor-related peptides in the pathogenesis of human breast cancer. Breast Cancer Res. Treat., 29:11-27.
36. Pelletier, J., and Sonenberg, N. (1985) Insertation mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell, 40:515-526.
37. Plowman, G.D., Green, J.M., McDonald, V.L., Neubauer, M.G., Disteche, C.M., Todaro, G.J., and Shoyab, M. (1990) The amphiregulín gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol. Cell. Biol., 10:1969-1981.
38. Qi, C.-F., Liscia, D.S., Merlo, G., Normanno, N., Johnson, J., Gullick, W.J., Ciardiello, F., Kim, N., and Salomon, D.S. (1994) Expression of transforming growth factor alpha, amphiregulin, and cripto-1 in human breast carcinomas. Br. J. Cancer, 69:903-910.
39. Rall, L.B., Scott, J., Bell, G.J., Crowford, R.J., Penchow, J.D., Niall, H.D., and Coghlan, J.P. (1985) Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature, 113:228-231.
40. Russo, J., Tay, L.K., and Russo, I.H. (1982) Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res. Treat., 2:5-73.
41. Russo, J., Rivera, R., and Russo, I.H. (1992) Influence of age and parity on the development of the human breast. Breast Cancer Res. Treat. 23:211-218.
42. Saeki, T., Chen-Geng, Q., Johnson, G.R., Gullick, W.J., Tahara, E., Normanno, N., Ciardiello, F., Kenny, N., Stromberg, K., and Salomon, D.S. (1991) Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors. Cancer Res., 52:3467-3473.
43. Sandgren, E.P., Luetteke, N.C., Palmiter, R.D., Brinster, R.L., and Lee, D.C. (1990) Overexpression of TGF alpha in transgenic mice: Induction of epithelial, hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell, 61:1121-1135.
44. Shantz, L., and Pegg, A. (1994) Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. Cancer Res., 54:2313-2316.
45. Snedeker, S.M., Brown, C.F., and DiAugustine, R.P. (1991) Expression and functional properties of transforming growth factor-alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proc. Natl. Acad. Sci. U.S.A., 88:276-280.
46. Springer, J.E., Gwag, B.J., Lewis, M.E., Baldino, F. (1991) Non-radioactive detection of nerve growth factor (NGFR) mRNA in rat brain using in situ hybridization histochemistry. J. Histochem. Cytoch., 39:231-234.
47. Threadgill, D.W., Dlugosz, A.A., Hansen, L.A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R.C., Barnard, J.A., Yuspa, S.H., Coffey, R.J., and Magnuson, T. (1995) Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science. 269:230-234.
48. Todaro, G.J., Rose, T.M., Spooner, C.E., Shoyab, M., and Plowman, G.D. (1990) Cellular and viral ligands that interact with the EGF receptor. Sem. in Cancer Biol., 1:257-263.
49. Vaughan, T.J., Pascall, J.C., and Brown, K.D. (1992) Nucleotide sequence and tissue distribution of mouse transforming growth factor-alpha. Biochim. Biophys. Acta. 1132:322-324.