Kinetics of arylamine N-acetyltransferase in tissues from human breast cancer

Cancer Letters

Volumn 111, Issue 1-2, 1997, Pages 39-50

  Lee, J H ^a   Chung, J G ^a   Lai, J M ^a   Levy, G N ^b   Weber, W W ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Breast cancer; N acetyltransferase; Tamoxifen

Indexed keywords

2 FLUORENYLAMINE; 4 AMINOBENZOIC ACID; ANTIESTROGEN; ARYLAMINE ACETYLTRANSFERASE; ESTROGEN RECEPTOR; TAMOXIFEN;

ADULT; AGED; ARTICLE; BREAST; BREAST CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME KINETICS; FEMALE; HUMAN; HUMAN TISSUE; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL;

4-AMINOBENZOIC ACID; ACETYLATION; ANTICARCINOGENIC AGENTS; ARYLAMINE N-ACETYLTRANSFERASE; BREAST; BREAST NEOPLASMS; CARCINOGENS; FEMALE; FLUORENES; HUMANS; NEOPLASM PROTEINS; PHENOTYPE; TAMOXIFEN;

EID: 0031031373     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04491-6     Document Type: Article

References (42)

1. Ambrosome, C.B., Freudenheim, J.L., Marshall, J.R., Graham, S., Vena, J.E., Brasure, J.R., Michalek, A.M., Laughlin, R., Nemoto, T. and Shields, P.G.(1995) Ann. N. Y. Acad. Sci., 758, 250-252.
2. Andres, H.H., Klem, A.J., Szabo, S.M. and Weber, W.W. (1985) New spectrophotometric and radiochemical assays for acetyl CoA: arylamine N-acetyltransferase applicable to a variety of arylamines, Anal. Biochem., 145, 367-375.
3. Bradford, M.M (1976) A rapid and sensitive method for the quantities of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248-254.
4. Bulovskaya, L.N., Krupkin, R.G., Bochina, T.A., Shipkovas, A.A. and Pavlova, M.V. (1978) Acetylator phenotypes in patients with breast cancer, Oncology, 35, 185-188.
5. Cartwright, R.A., Glasham, H.J., Rogers, R.A., Ahmad, R.A., Barham-Hall, D., Higgins, E. and Kaha, M.A. (1982) The role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer, Lancet, 2, 842-846.
6. Cartwright, R.A. (1984) Epidemiological studies of N-acetylalion and C-center ring oxidation in neoplasia, In: Genetic Variability in Response to Chemical Exposure, pp. 359-368. Editors: G.S. Omen and H.V. Gelboin. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
7. Chung, J.G., Levy, G.N. and Weber, W.W. (1993) Distribution of 2-aminofluorene and p-aminobenzoic acid N-acetyl-transferase activity in tissues of C57BL/6J rapid and B6.A-nats slow acetylator congenic mice, Drug Metab. Dispos., 21, 1057-1063.
8. Cleland, W.W. (1963) Computer programs for processing enzyme kinetic data, Nature, 194, 463-465.
9. Early Breast Cancer Trialists Collaborative Group (1988) The effects of adjuvant tamoxifen and cytotoxic therapy on mortality in early breast cancer: an overview of 61 randomized trials among 25896 women. N. Engl. J. Med., 319, 1681-1685.
10. Flammang, T.J., Yamazoc, Y., Guengerich, F.P. and Kadlubar, F.F. (1987) The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-amino-fluorescence by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype, Carcinogenesis, 8, 1967-1970.
11. Forrest, A.P.M. Breast Cancer Screening: Report to the Health Ministers of England, Wales, Scotland and Northern Ireland. HMSO, London.
12. Glowinsk, I.B., Radtke, H.E. and Weber, W.W. (1978) Genetic variation in N-acetylation of carcinogenic arylamines by human and rabbit liver, Mol. Pharmacol., 14, 940-949.
13. Grants, D.M., Blum, M., Bear, M. and Myer, U.A. (1991) Monomorphic and polymorphic human arylamine NAT: a comparison of liver isozymes and expressed products of two cloned genes, Mol. Pharmacol., 39, 184-191.
14. Hearse, D.J. and Weber, W.W. (1973) Multiple N-acetyl-transferase and drug metabolism, tissue distribution, characterization and significance of mammalian N-acetyltransferase, Biochem. J., 132, 519-526.
15. Hein, D.W., Hirata, M. and Weber, W.W. (1981) An enzyme marker to ensure reliable determinations of human isoniazid acetylator phenotype in vitro, Pharmacology, 23, 203-210.
16. Hein, D.W., Kirlin, W.G., Trinidad, A., Yerokun, T. and Andrews, A.F. (1987) Human colon N-acetyltransferase activity towards carcinogenic arylamine substrates: kinetic constant and partial purification, Pharmacologist, 29, 178-184.
17. Ikin, D.W. (1988) Genetic polymorphism and cancer susceptibility: evidence concerning acetyltransferase and cancer of the urinary bladder, Bioassays, 9, 100-104.
18. Ilett, K.K., David, B.M., Detchon, P., Castledon, W.M. and Kwa, R. (1987) Acetylator phenotype in colorectal carcinoma, Cancer Res., 47, 1466-1469.
19. Jordan, V.C. (1988) Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinoma, Eur. J. Cancer, 12, 419-425.
20. Jordan, V.C., Lababidi, M.K. and Mireki, D.M. (1990) The antiestrogen and anti-tumor properties of prolonged tamoxifen therapy in C3H10UJ mice, Eur. J. Cancer, 26, 718-725.
21. Kilbane, A.J., Petroff, T. and Weber, W.W. (1985) Michaelis - Menten constants for arylamine drugs in rapid and slow human acetylator liver, FASEB J., 2, A1140.
22. Kilbane, A.J., Petroff, T. and Weber, W.W. (1991) Kinetics of acetyl CoA: arylamine N-acetyltransterase from rapid and slow acetylator human liver, Drug Metab. Dispos., 19. 503-507.
23. King, C.H. and Allaben, W.T. (1978) The role of arylhydroxamic acid N-O acetyltransferase in the carcinogenicity of aromatic amines. In: Conjugation Reactions in Drug Biotransformation, pp. 432-444. Editor: A. Akio. Elscvier North Holland Biomedical Press, New York.
24. Kirlin, W.G., Trinzdad, A., Yerokun, T., Ogolla, E., Ferguson, R.J., Andrews, A.F., Brady, P.K. and Hein, D.W. (1989) Polymorphic expression of AcCoA dependent acrylamine N-acetyltransferase and AcCoA-dependent O acetyl-transferase mediated activation of N-hydroxyarylamine by human bladder cytosol, Cancer Res., 49, 2448-2454.
25. Ladero, J.M., Fernandez, M.J., Palmeiro, R., Munoz, J.J., Jura, C., Lazaro, C. and Pertz-Manga, G. (1987) Hepatic acetylator polymorphism in breast cancer patients, Oncology, 44, 341-344.
26. Land, S.J., Zukowski, K., Lee, M.S., Debiec-Rychter, King, C.M. and Wang, C.Y. (1988) Metabolism of aromatic amines: relationships of n-acetylation, O-acetylation, N-O-acetyltransferase, N-acetylation, and deacetylation in human liver. Proc. Am. Assoc. Cancer Res., 29, 122-127.
27. Lang, N.P., Chu, D.Z.J., Hunter, C.F., Kendall, D.C., Flammang, T.J. and Kadlubar, F.F. (1987) Role of aromatic amine acetyltransferase in human colorectal cancer, Arch. Surg., 121, 1259-1261.
28. Levy, G.N., Chung, J.G. and Weber, W.W. (1994) 2-AF metabolism and DNA adduct formation by mononuclear leucocytes from rapid and slow acetylator mouse strain, Carcinogenesis, 5, 353-357.
29. Malejka-Giganti, D., Rydell, R.E. and Guttman, H.R. (1973) Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acid, Cancer Res., 33, 2489-2497.
30. Malejka-Giganti, D., Rydell, R.E. and Guttman, H.R. (1975) Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acid and their acetate, Cancer Res., 37, 111-117.
31. Martell, K.J., Levy, G.N. and Weber, W.W. (1992) Cloned mouse N-acetyltransferase enzymatic properties of expressed Nat-1 and Nat-2 gene products, Mol. Pharmacol., 42, 265-272.
32. Mattano, S.S. and Weber, W.W. (1987) Kinetics of arylamine N-acetyltransferase in tissues from rapid and slow acetylator mice, Carcinogenesis, 8, 133-137.
33. Philip, P.A., Rogers, H.J., Millis, R.R., Rubens, R.D. and Cartwright, R.A. (1987) Acetylator status and its relationship to breast cancer and other diseases of the breast, Eur. J. Cancer Clin. Oncol., 23, 1701-1706.
34. Rojanapo, W., Kupradinum, P., Tepsuwan, A., Chutimatuewin, S., Tanyakuset, M., Saititnimankarn, T. and Sombooncharoen, S. (1986) Carcinogenicity of an oxidation product of phenylenediamine, Carcinogenesis, 7, 1977-2002.
35. Rojanapo, W., Chutimatuewin, S., Kupradinum, P., Tepsuwan, A., Tanyakuset, M., Saititnimankarn, T. and Sombooncharoen, S. (1986) Carcinogenicity of hair dye in Thailand, Thai Cancer J., 12, 43-56.
36. Searle, C.E., Harnden, D.G., Venitt, S. and Gyde, O.H.B. (1975) Carcinogenicity and mutagenicity test of some hair colorant and constitutes, Nature, 255, 506-507.
37. Siess, E.A., Brocks, P.G. and Wieland, O.H. (1976) Subcellular distribution of key metabolites in isolated liver cells from fasted rats, FEBS Lett., 69, 265-271.
38. Shore, R.E., Pasternack, B.S., Thiessen, E.U., Sadow, M., Foebes, R. and Arbert, R.E. (1979) A case-control study of hair dye use and breast cancer, J. Natl. Cancer Inst., 62, 277-283.
39. Trinidad, A.F. (1989) Kinetic characterization of acetylator genotype-dependent and independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol, Drug Metab. Dispos., 17, 238-247.
40. Wang, C.Y., Linsmaier-Bedriar, E.M., Gamer, C.D. and Lee, M.S. (1982) Induction of unscheduled DNA primary culture of dog, rat, and mouse urothelial cells by arylamine and nitrofuran derivatives, Cancer Res., 42, 3974-3977.
41. Weber, W.W. and Hein, D.W.(1985) N-Acetylation pharmacogenetics. Pharmacol. Rev., 37, 25-79.
42. Wilson, R. (1985) Risks posed by various components of hair dyes, Arch. Dermatol. Res., 278, 165-170