Peak assignment in localized 1H MR spectra of human muscle based on oral creatine supplementation

Magnetic Resonance in Medicine

Volumn 37, Issue 2, 1997, Pages 159-163

  Kreis, Roland ^a,c   Koster, Markus ^b   Kamber, Matthias ^b   Hoppeler, Hans ^a   Boesch, Chris ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Swiss Sports School   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

creatine; dipolar coupling; skeletal muscle

Indexed keywords

MOLECULAR DYNAMICS;

CREATINE; CREATINE SUPPLEMENTATIONS; DIFFERENCE SPECTROSCOPY; DIPOLAR COUPLINGS; HUMAN MUSCLES; MAGIC ANGLE; SKELETAL MUSCLE; SPECTRAL SIMULATIONS;

MUSCLE;

CREATINE; CREATINE PHOSPHATE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EXERCISE; HUMAN; HUMAN EXPERIMENT; MALE; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MUSCLE LEVEL; NORMAL HUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SKELETAL MUSCLE; SUPPLEMENTATION; THIGH; TIBIALIS ANTERIOR MUSCLE;

EID: 0031031163     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910370202     Document Type: Article

References (22)

1. S. R. Williams, D. G. Gadian, E. Proctor, D. B. Sprague, D. F. Talbot, I. R. Young, F. F. Brown, Proton NMR studies of muscle metabolites in vivo. J. Magn. Reson. 63, 406-412 (1985).
2. 1H spectroscopic studies of human gastrocnemius muscle at 1.5 T. Magn. Reson. Imag. 6, 481-485 (1988).
3. H. Bruhn, J. Frahm, M. L. Gyngell, K. D. Merboldt, W. Haenicke, R. Sauter, Localized proton NMR spectroscopy using stimulated echoes: Applications to human skeletal muscle in vivo. Magn. Reson. Med. 17, 82-94 (1991).
4. 1H NMR. Magn. Reson. Med. 20, 57-65 (1991).
5. F. Schick, B. Eismann, W. I. Jung, H. Bongers, M. Bunse, O. Lutz, Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue. Magn. Reson. Med. 29, 158-167 (1993).
6. R. Kreis, C. Boesch, Liquid-crystal-like structures of human muscle demonstrated by in vivo observation of direct dipolar coupling in localized proton magnetic resonance spectroscopy. J. Magn. Reson, Series B 104, 189-192 (1994).
7. R. Kreis, C. Boesch, Spatially localized, one- and two-dimensional NMR spectroscopy and in vivo application to human muscle. J. Magn. Reson. Series B, 113, 103-118 (1996).
8. 1H MRS spectra from rat skeletal muscle, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 1087.
9. 31P-MRS, MRI, exercise performance testing and clinical chemistry, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 25.
10. P. A. Bottomley, U.S. patent 4,480,228 (1984).
11. 1H MRS. in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 45.
12. J. Hennig, The application of phase rotation for localized in vivo proton spectroscopy with short echo times. J. Magn. Reson. 96, 40-49 (1992).
13. R. Kreis, T. Ernst, B. D. Ross, Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations. J. Magn. Reson. Series B 102, 9-19 (1993).
14. W. Studer, SMART, a general purpose pulse experiment simulation program using numerical density matrix calculations. J. Magn. Reson. 77, 424-438 (1988).
15. M. Wyss, T. Wallimann, I-4 Creatine metabolism and the consequences of creatine depletion in muscle. Mol. Cell. Biochem. 133, 51-66 (1994).
16. 1H-MRS, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 31.
17. 1H-MR spectra of human muscle, in "Proc., SMR, 3rd Annual Meeting, Nice, France, 1995," p. 430.
18. P. L. Greenhaff, Creatine and its application as an ergogenic aid. Int. J. Sport Nutr. 5, S100-S110 (1995).
19. V. Ööpik, S. Timpmann, L. Medijainen, The role and application of dietary creatine supplementation in increasing physical performance capacity. Biol Sport 12, 197-212 (1995).
20. 1H magnetic resonance spectroscopy. J. Magn. Reson. Series B 107, 242-251 (1995).
21. G. Wegmann, E. Zanolla, H. M. Eppenberger, T. Wallimann, In situ compartmentation of creatine kinase in intact sarcomeric muscle: the acto-myosin overlap zone as a molecular sieve. J. Muscle Res. Cell Motil. 13, 420-435 (1992).
22. G. E. Pake, Nuclear resonance absorption in hydrated crystals: Fine structure of the proton line. J. Chem. Phys. 16, 327-336 (1948).