S1 heterocyclic thrombin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 1, 1997, Pages 79-84

  Dominguez, C ^a   Carini, D J ^a   Weber, P C ^a,b   Knabb, R M ^a   Alexander, R S ^a   Kettner, C A ^a   Wexler, R R ^a  

^a DUPONT COMPANY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL DEXTRO PHENYLALANYLPROLYLBOROARGININE; BORON DERIVATIVE; THROMBIN INHIBITOR;

ARTICLE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; PEPTIDE SYNTHESIS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0031031115     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00584-7     Document Type: Article

References (11)

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3. (b) Radcliffe, R.; Nemerson, Y. In Methods in Enzymology; Lorand, L., Ed; Academic: London, 1976, Vol XLV, p 49.
4. (a) Okamoto, S.; Hijikata, A. Biochim. Biophys. Res. Commun. 1981, 101, 440.
5. (b) Hifijikata-Okunomiya, A.; Okamoto, S. Thromb. Haemostasis 1992, 18, 135.
6. (c) Angliker, H.; Wilstrom, P.; Shaw, E. Biochim J. 1990, 266, 829.
7. (d) Elgendy, S.; Deadman, J.; Patel, G.; Green, D.; Chino, N.; Goodwin, C. A.; Scully, M. F.; Kakkar, V. V.; Claeson, G. Tetrahedron Lett. 1992, 33, 4209.
8. (e) Misra, R. N.; Kelly, Y. K.; Brown, B. R.; Roberts, D. G. G. M.; Chong, S.; Seiler, S. M. Bioorg. Med. Chem. Lett. 1994, 4, 2165.
9. factor 0.211.
10. Matteson, D. S.; Jeshi, P. K.; Sadha, K. M. Organometallics 1984, 3, 1284.
11. Satisfactory spectral data were obtained for all new compounds.