Indomethacin and nordihydroguaiaretic acid inhibition of amyloid β protein (25-35) activation of phospholipases A2 and D of LA-N-2 cells

Neuroscience Letters

Volumn 222, Issue 1, 1997, Pages 5-8

  Singh, I N ^a   Sorrentino, G ^b   Sitar, D S ^a   Kanfer, J N ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Alzheimer's disease; Amyloid protein; Indomethacin; Non steroidal anti inflammatory drugs; Nordihydroguaiaretic acid; Phospholipase A2; Phospholipase C; Phospholipase D

Indexed keywords

ACETYLSALICYLIC ACID; AMYLOID BETA PROTEIN; GENTISIC ACID; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; NORDIHYDROGUAIARETIC ACID; PARACETAMOL; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PHOSPHOLIPASE D; SULINDAC SULFONE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL;

AMYLOID BETA-PROTEIN PRECURSOR; BRAIN NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOMETHACIN; NEUROBLASTOMA; NORDIHYDROGUAIARETIC ACID; PHOSPHOLIPASES; TUMOR CELLS, CULTURED;

EID: 0031030246     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)13327-4     Document Type: Article

References (27)

1. Khachaturian, Z.S., Diagnosis of Alzheimer's disease, Arch. Neurol., 42 (1985) 1097-1105.
2. Selkoe, D., Cell biology of the amyloid β protein precursor protein and the mechanism of Alzheimer's disease, Annu. Rev. Cell Biol., 10 (1994) 373-403.
3. Iversen, L.L., Mortishire-Smith, R.J., Pollack, S.J. and Sheerman, M.S., The toxicity in vitro of beta amyloid protein, Biochem. J., 311 (1995) 1-16.
4. Pike, C., Burdick, D., Walencewicz, A.J., Glabe, C.G. and Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state, J. Neurosci., 13 (1993) 1676-1687.
5. McGeer, P.L., McGeer, E., Rogers, J. and Sibley, J., Anti-inflammatory drugs and Alzheimer's disease, Lancet, 335 (1990) 1037.
6. Canadian Study of Health and Aging, The Canadian study of health and aging: risk factors for Alzheimer's disease in Canada, Neurology, 44 (1994) 2073-2080.
7. Singh, I.N., McCartney, D.G. and Kanfer, J.N., Amyloid beta protein (25-35) stimulation of phospholipases A, C and D activities of LA-N-2 cells, FEES Lett., 365 (1995) 125-128.
8. 2 in LA-N-2 cells, Alzheim. Res., 2(4) (1996) in press.
9. Singh, I.N., Sorrentino, G. and Kanfer, J.N., Amyloid beta protein (25-35) stimulation of phospholipase C in LA-N-2 cells, J. Neurochem., submitted.
10. Singh, I.N., Sorrentino, G., McCartney, D.G., Massarelli, R. and Kanfer, J.N., Enzymatic activities during differentiation of human neuroblastoma cells, LA-N-1 and LA-N-2, J. Neurosci. Res., 25 (1990) 476-485.
11. Singh, I.N., Massarelli, R. and Kanfer, J.N., Activating phospholipases D and A by amphiphillic cations of cultured LA-N-2 cells is G protein and protein kinase C-independent, J. Lipid Mediat., 7 (1993) 85-96.
12. Sorrentino, G., Singh, I.N., Massarelli, R. and Kanfer, J.N., Stimulation of phospholipase C activity by norepinephrine t-ACPD and bombesin in LA-N-2 cells, Eur. J. Pharmacol., 308 (1996) 81-86.
13. Lowry, O.H., Rosebrough, N.G., Farr, A.L. and Randall, R.J., Protein measurement with Polin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
14. Wilkinson, L., SYSTAT: The System for Statistics, SYSTAT Inc., Evanston, IL, 1990.
15. McGeer, P.L. and McGeer, E.G., The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases, Brain Res. Rev., 21 (1995) 195-218.
16. Mackenzie, I.R., Hao, C. and Munoz, D.G., Role of microglia in senile plaque formation, Neurobiol. Aging, 16 (1995) 797-804.
17. Giulian, D., Haverkamp, L.J., Karskin, W.L., Yu, J., Tom, D., Li, X. and Kirkpatrick, J.B., Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer's brain, Neurochem. Int., 27 (1995) 119-137.
18. McGeer, P.L. and Rogers, J., Anti-inflammatory drugs as a therapeutic approach to Alzheimer's disease, Neurology, 42 (1992) 447-449.
19. 2 in polymorphonuclear leukocytes, Am. J. Pharmacol., 46 (1988) 275-284.
20. Shakir, K.M., Simpkins, C.O., Gartner, S.L., Sobel, D.O. and Williams, T.J., Phospholipase C activity in human polymorphonuclear leukocytes; partial characterization and effect of indomethacin, Enzyme, 42 (1989) 197-208.
21. 3H] inositol phosphates in human platelets by palmitoyl lysophosphatidic acid is blocked by indomethacin, Biochem. Biophys. Res. Commun., 132 (1985) 555-562.
22. Sanfeliu, C., Hunt, A. and Patel, A.J., Exposure to N-methyl-D aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes, Brain Res., 529 (1990) 241-248.
23. 2+ from intracellular stores, J. Biol. Chem., 266 (1991) 4295-4302.
24. Bruce-Jones, P.N.E., Crome, P. and Kalra, L., Indomethacin and cognitive functions in healthy elderly volunteers, Br. J. Clin. Pharmacol., 38 (1994) 45-51.
25. Faragasan, M.O. and Aisen, P.S., IL-1 and anti-inflammatory drugs modulate Aβ cytotoxicity in PC12 cells, Brain Res., 723 (1996) 231-234.
26. Goodman, Y., Steiner, M.R., Steiner, S.M. and Mattson, M.P., Nordihydrogulaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity and attenuates free radical and calcium accumulation, Brain Res., 654 (1994) 171-176.
27. Rogers, J., Kirby, L.C., Hempelman, S.R., Berry, D.L., McGeer, P.L. and Kaszniak, A.W., et al., Clinical trial of indomethacin in Alzheimer's disease, Neurology, 43 (1993) 1609-1611.