Acute incretin response to oral glucose is associated with stimulation of gastric inhibitory polypeptide, not glucagon-like peptide in young subjects

Pediatric Research

Volumn 41, Issue 3, 1997, Pages 364-367

  Limb, Charles ^a   Tamborlane, William V ^a   Sherwin, Robert S ^a   Pederson, R ^b   Caprio, Sonia ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CHOLECYSTOKININ; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE; GLUCOSE; INSULIN; SECRETIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADOLESCENT; ADULT; ARTICLE; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

EID: 0031029313     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199703000-00010     Document Type: Article

References (23)

1. Ebert R, Creutzfeldt W 1987 Gastrointestinal peptides and insulin secretion. Diabetes Metab Rev 3:1-26
2. Brown JC, Mutt V, Pederson RA 1970 Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol (Lond) 209:57-64
3. Beck B 1989 Gastric inhibitory polypeptide: a gut hormone with anabolic functions. Mol Endocrinol 2:169-174
4. Kuzio M, Dryburgh JR, Malloy KM, Brown JC 1974 Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology 66:357-364
5. Brown JC, Otte SC 1978 Gastrointestinal hormones and the control of insulin secretion. Diabetes 27:782-789
6. Weir GC, Mojsov S, Hendrick GK, Habener JF 1989 Glucagon-like peptide 1 (7-37) actions on endocrine pancreas. Diabetes 38:338-342
7. Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L 1986 Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889
8. Kreymann B, Ghatei MA, William G, Bloom SR 1987 Glucagon-like peptide 1(7-36): a physiological incretin in man. Lancet 11:1300-1304
9. Andersen DK, Elahi D, Brown JC, Tobin JD, Andres R 1978 Oral glucose augmentation of insulin secretion. J Clin Invest 62:152-161
10. Elahi D, Andersen DK, Brown JC, Debas HT, Hershcopf RJ, Raizes GS, Tobin JD, Andres R. 1979 Pancreatic alpha- and beat-cell responses to GIP infusion in normal man. Am J Physiol 237:E185-E191
11. Ebert R, Unger H, Creutzfeldt W 1983 Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption. Diabetologia 24:449-454
12. Lauritsen KB, Holst JJ, Moody AJ 1981 Depression of insulin release by anti-GIF serum after oral glucose in rats. Scand J Gastroenterol 16:417
13. Ebert R, Creutzfeldt W. 1982 Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in rats. Endocrinology 111:1601
14. Mojsov S, Weir GC, Habener JF 1987 Insulinotropin: glucagon-like peptide 1(7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79:616-619
15. Thorens B, Weber G 1993 Glucagon-like peptide-1 and the control of insulin secretion in the normal state and in NIDDM. Diabetes 42:1219-1225
16. Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF 1987 Glucagon-like peptide 1 stimulates insulin gene expression and increases cyclic AMP levels in rat islet cell lines. Proc Natl Acad Sci USA 84:3434-3438
17. Thorens B 1992 Expression cloning of the pancreatic beta-cell receptor for the glucoincretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89:8641-8645
18. Gutniak M, Oskov C, Holst J, Ahren B, Efendic S 1992 Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide-1(7-36 amide) in normal subjects and patients with diabetes mellitus. N Engl J Med 326:1316-1322
19. Nauck MA, Kleine N, Oskov C, Holst JJ, Creutzfeldt W 1993 Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide-1(7-36 amide) in type 2 (non-insulin dependent) diabetic patients. Diabetologia 36:741-744
20. DeFronzo RA, Tobin JD, Andres R 1979 Glucose clamp technique: a method for quantifying insuln secretion and resistance. Am J Physiol 237:E214-E223
21. Mojsov S, Kopcrzynski MG, Hebener JF 1990 Both amidated and non-amidated forms of glucagon-like peptide 1 are synthesized in the rat intestine and pancreas. J Biol Chem 265:8001-8008
22. Eissele R, Göke R, Willemer S, Harthus HP, Veemeer H, Arnold R, Göke B 1992 Glucagon like-peptide 1(7-36) amide cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 22:282-291
23. Schirra J, Katschinski M, Weidmann C, Schafer T, Wanke U, Arnold R, Göke B 1996 Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 97:92-103