Persistent inhibition of platelets during continuous nitroglycerin therapy despite hemodynamic tolerance

Circulation

Volumn 95, Issue 5, 1997, Pages 1308-1313

  Hébert, Daniel ^a   Xiang, Jian Xin ^a   Lam, Jules Y T ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

Author keywords

hemodynamics; nitroglycerin; platelets; thrombosis; vasodilation

Indexed keywords

GLYCERYL TRINITRATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG TOLERANCE; NONHUMAN; PRIORITY JOURNAL; SWINE; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 0031029309     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.5.1308     Document Type: Article

References (12)

1. Parker JO. Nitrate therapy in stable angina. N Engl J Med. 1987;316:1634-1642.
2. Abrams J. A reappraisal of nitrate therapy. JAMA. 1988;259:396-401.
3. Feldman RL, Conti CR. Relief of myocardial ischemia with nitroglycerin: what is the mechanism? Circulation. 1982;64:1098-1100.
4. Van de Voorde J, Vanderstichele H, Leusen I. Release of endothelium-derived relaxing factor from human umbilical veins. Circ Res. 1987;60:517-522.
5. Radomski MW, Palmer RMJ, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987;2:1057-1058.
6. de Graaf JC, Banga JD, Moncada S, Palmer RMJ, de Groot PG, Sixma JJ. Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. Circulation. 1992;85:2284-2290.
7. Johnstone MT, Lam JYT, Lacoste L, Baribeau J, Théroux P, Waters D. Methylene blue inhibits the antithrombotic effect of nitroglycerin. J Am Coll Cardiol. 1993;21:255-259.
8. Lam JYT, Chesebro JH, Fuster V. Platelets, vasoconstriction, and nitroglycerin during arterial wall injury: a new antithrombotic role for an old drug. Circulation. 1988;78:712-716.
9. Lam JYT, Chesebro JH, Steele PM, Badimon L, Fuster V. Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injury in vivo. Circulation. 1987;75:243-248.
10. Diodatti J, Théroux P, Latour JG, Lacoste L, Lam JYT, Waters D. Effects of nitroglycerin at therapeutic doses on platelet aggregation in unstable angina pectoris and acute myocardial infarction. Am J Cardiol. 1990;66:683-688.
11. Lacoste LL, Théroux P, Lidon RM, Colucci R, Lam JYT. Antithrombotic properties of transdermal nitroglycerin in stable angina pectoris. Am J Cardiol. 1994;73:1058-1062.
12. Karlberg KE, Torfgard K, Ahlner J, Sylvén C. Dose-dependent effect of intravenous nitroglycerin on platelet aggregation, and correlation with plasma glyceryl dinitrate concentration in healthy men. Am J Cardiol. 1992;69:802-805.